{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-08-11",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 4
    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "BiEST 5.0 Estrogen Cream - 3.6oz estriol,estradiol ALLANTOIN LECITHIN, SUNFLOWER ESTRIOL ESTRIOL ESTRADIOL ESTRADIOL ISOPROPYL PALMITATE STEARIC ACID SHEA BUTTER ALOE VERA LEAF COCONUT OIL SODIUM BICARBONATE OLIVE OIL GLYCERIN"
      ],
      "active_ingredient": [
        "DRUG FACTS Active Ingredients Micronizrd Estriol USP (Wild Yam) .4% Micronizrd Estradiol USP (Wild Yam) .1%"
      ],
      "purpose": [
        "This is a topical cream that contains bio-identical estriol and estradiol derived from wild yam and formulated in an 80:20 ratio. When applied to the skin it can help balance your hormones and provide temporary relief from menopausal symptoms such as hot flashes."
      ],
      "indications_and_usage": [
        "USES: This is a topical cream that contains bio-identical estriol and estradiol derived from wild yam and formulated in an 80:20 ratio. When applied to the skin it can help balance your hormones and provide temporary relief from menopausal symptoms such as hot flashes. DIRECTIONS: Apply once or twice a day. Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together or use as directed by your Physician."
      ],
      "warnings": [
        "For external cosmetic use only. If pregnant or nursing, consult a healthcare professional before using this product. Cease using this product and seek medical attention if skin irritation or other negative reactions occur. Do not use if tamper-evident seal is broken or missing. California Prop 65 Law requires this statement: This product contains estrogen, a chemical known only to the state of California to cause cancer. KEEP OUT OF REACH OF CHILDREN."
      ],
      "pregnancy_or_breast_feeding": [
        "If pregnant or nursing or if you have a serious medical condition consult a healthcare professional before using this product."
      ],
      "keep_out_of_reach_of_children": [
        "Keep Out of Reach of Children."
      ],
      "dosage_and_administration": [
        "Apply once or twice a day. Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together or use as directed by you physician."
      ],
      "inactive_ingredient": [
        "Purified Water, Vegetable Glycerin, Aloe Vera Gel, Caprylic/Capric Triglyceride,Stearic Acid,Olive Oil, Coconut Oil, Shea Butter, Sunflower Lecithin, Methylsulfonylmethane (MSM), Stearyl Alcohol, Isopropyl Palmitate,Allantoin,Carbomer, Sodium Bicarbonate, Herbal-Active (Natural Preservstive)"
      ],
      "questions": [
        "Questions? care@biolabspro.com www.biolabspro.com"
      ],
      "package_label_principal_display_panel": [
        "Biest5_3.6_Label"
      ],
      "set_id": "37d33647-9790-35a8-e063-6294a90a2ad9",
      "id": "37d335c6-fe0f-b203-e063-6394a90a24d8",
      "effective_time": "20250601",
      "version": "1",
      "openfda": {
        "brand_name": [
          "BiEST 5.0 Estrogen Cream - 3.6oz"
        ],
        "generic_name": [
          "ESTRIOL,ESTRADIOL"
        ],
        "manufacturer_name": [
          "SHYNE BRANDS/BIOLabs PRO"
        ],
        "product_ndc": [
          "82018-0029"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "TRANSDERMAL"
        ],
        "substance_name": [
          "ESTRIOL",
          "ESTRADIOL"
        ],
        "spl_id": [
          "37d335c6-fe0f-b203-e063-6394a90a24d8"
        ],
        "spl_set_id": [
          "37d33647-9790-35a8-e063-6294a90a2ad9"
        ],
        "package_ndc": [
          "82018-0029-5"
        ],
        "is_original_packager": [
          true
        ],
        "upc": [
          "0850048284401"
        ],
        "nui": [
          "M0447348",
          "N0000175825",
          "N0000000100"
        ],
        "pharm_class_cs": [
          "Estradiol Congeners [CS]"
        ],
        "pharm_class_epc": [
          "Estrogen [EPC]"
        ],
        "pharm_class_moa": [
          "Estrogen Receptor Agonists [MoA]"
        ],
        "unii": [
          "FB33469R8E",
          "4TI98Z838E"
        ]
      }
    }
  ]
}