{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-06-02",
    "results": {
      "skip": 0,
      "limit": 1,
      "total": 3
    }
  },
  "results": [
    {
      "spl_product_data_elements": [
        "apo-OEDEM Horse Chestnut, Apocynum cannabinum Root, Convallaria majalis Flowering Top, Helleborus niger Root, Thuja occidentalis Leafy Twig, Sambucus nigra Flowering Top, Filipendula ulmaria Root, and Corn Silk HORSE CHESTNUT HORSE CHESTNUT APOCYNUM CANNABINUM ROOT APOCYNUM CANNABINUM ROOT CONVALLARIA MAJALIS FLOWERING TOP CONVALLARIA MAJALIS FLOWERING TOP HELLEBORUS NIGER ROOT HELLEBORUS NIGER ROOT THUJA OCCIDENTALIS LEAFY TWIG THUJA OCCIDENTALIS LEAFY TWIG SAMBUCUS NIGRA FLOWERING TOP SAMBUCUS NIGRA FLOWERING TOP FILIPENDULA ULMARIA ROOT FILIPENDULA ULMARIA ROOT CORN SILK CORN SILK WATER ALCOHOL"
      ],
      "active_ingredient": [
        "Ingredients: Aesculus hippocastanum 4X Apocynum cannabinum 3X Convallaria majalis 12X Helleborus niger 4X Sambucus nigra 4X Filipendula ulmaria (Spiraea ulmaria) 6X Stigmata maydis 4X Thuja occidentalis 6X Selected ingredients prepared by spagyric processes."
      ],
      "active_ingredient_table": [
        "<table width=\"50%\"><col width=\"60%\" align=\"center\" valign=\"middle\"/><col width=\"40%\" align=\"center\" valign=\"middle\"/><thead><tr><th align=\"left\"> Ingredients: </th><th/></tr></thead><tbody><tr><td align=\"left\">Aesculus hippocastanum</td><td align=\"right\">4X</td></tr><tr><td align=\"left\">Apocynum cannabinum</td><td align=\"right\">3X</td></tr><tr><td align=\"left\">Convallaria majalis</td><td align=\"right\">12X</td></tr><tr><td align=\"left\">Helleborus niger</td><td align=\"right\">4X</td></tr><tr><td align=\"left\">Sambucus nigra</td><td align=\"right\">4X</td></tr><tr><td align=\"left\">Filipendula ulmaria (Spiraea ulmaria)</td><td align=\"right\">6X</td></tr><tr><td align=\"left\">Stigmata maydis</td><td align=\"right\">4X</td></tr><tr><td align=\"left\">Thuja occidentalis</td><td align=\"right\">6X</td></tr></tbody></table>"
      ],
      "inactive_ingredient": [
        "Contains 26% alcohol by volume."
      ],
      "indications_and_usage": [
        "Indications For relief of minor swelling. Application of this homeopathic remedy for the designated usage is exclusively based on homeopathic experience. With severe forms of this disease, a clinically proven therapy is indicated."
      ],
      "purpose": [
        "For relief of minor swelling. Application of this homeopathic remedy for the designated usage is exclusively based on homeopathic experience. With severe forms of this disease, a clinically proven therapy is indicated."
      ],
      "dosage_and_administration": [
        "Dosage Unless otherwise prescribed, adults take 15-20 drops, 3 times per day. For pediatric dosages, consult your practitioner."
      ],
      "warnings": [
        "Warning If symptoms persist, contact a licensed practitioner. If you have known sensitivity to any of the ingredients, please consult your licensed practitioner before use. If you are pregnant or nursing a baby, seek the advice of a health care professional before use. Keep out of the reach of children. Protect from light and heat."
      ],
      "keep_out_of_reach_of_children": [
        "Keep out of the reach of children."
      ],
      "storage_and_handling": [
        "Protect from light and heat."
      ],
      "spl_unclassified_section": [
        "Tamper Evident Do not use this product if tamper evident strip is broken or removed from base of cap.",
        "Distributed by: BioResource Inc. Cotati, CA 94931 Manufactured by: PEKANA ® GmbH D-88353 Kisslegg"
      ],
      "questions": [
        "To report adverse events, contact BioResource at 321B Blodgett Street, Cotati, CA 94931"
      ],
      "package_label_principal_display_panel": [
        "PRINCIPAL DISPLAY PANEL - 50 ml Bottle Box apo-OEDEM™ Oral Drops Homeopathic Medicine For relief of minor swelling 1.7 FL OZ (50 ml) PEKANA ® PRINCIPAL DISPLAY PANEL - 50 ml Bottle Box"
      ],
      "set_id": "36c831b4-f21a-490e-8cca-9a7773eae91e",
      "id": "317b4b69-0711-42ff-9895-b075cee0cea0",
      "effective_time": "20230111",
      "version": "2",
      "openfda": {
        "brand_name": [
          "apo-OEDEM"
        ],
        "generic_name": [
          "HORSE CHESTNUT, APOCYNUM CANNABINUM ROOT, CONVALLARIA MAJALIS FLOWERING TOP, HELLEBORUS NIGER ROOT, THUJA OCCIDENTALIS LEAFY TWIG, SAMBUCUS NIGRA FLOWERING TOP, FILIPENDULA ULMARIA ROOT, AND CORN SILK"
        ],
        "manufacturer_name": [
          "PEKANA Naturheilmittel Gmbh"
        ],
        "product_ndc": [
          "59469-302"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "ORAL"
        ],
        "substance_name": [
          "APOCYNUM CANNABINUM ROOT",
          "CONVALLARIA MAJALIS FLOWERING TOP",
          "CORN SILK",
          "FILIPENDULA ULMARIA ROOT",
          "HELLEBORUS NIGER ROOT",
          "HORSE CHESTNUT",
          "SAMBUCUS NIGRA FLOWERING TOP",
          "THUJA OCCIDENTALIS LEAFY TWIG"
        ],
        "spl_id": [
          "317b4b69-0711-42ff-9895-b075cee0cea0"
        ],
        "spl_set_id": [
          "36c831b4-f21a-490e-8cca-9a7773eae91e"
        ],
        "package_ndc": [
          "59469-302-10"
        ],
        "is_original_packager": [
          true
        ],
        "unii": [
          "2F92409L9Z",
          "4G7VTP9FC4",
          "7D3VB244UX",
          "997724QNDS",
          "608DGJ6815",
          "3C18L6RJAZ",
          "CT03BSA18U",
          "1NT28V9397"
        ]
      }
    }
  ]
}