{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-06-02",
    "results": {
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  "results": [
    {
      "spl_product_data_elements": [
        "Acnil Acnil Clindamycin Hydrochloride and Metronidazole Liniment METRONIDAZOLE METRONIDAZOLE CLINDAMYCIN HYDROCHLORIDE CLINDAMYCIN WATER 2-(ETHYLTHIO)ETHANOL GLYCEROL FORMAL"
      ],
      "warnings": [
        "",
        "ADVERSE REACTIONS: A few instance of local irritation or burning sensation may be observed. occasionally during the treatment. Allergic reaction can be observed rarely."
      ],
      "dosage_and_administration": [
        "DOSAGE AND ADMINISTRATION For external use only. Drip 1~2 drops of Acnil to affected area, or dip some Acnil in cotton bud and apply to the affected area. It should be applied three times daily. Two weeks’ treatment constitutes a single therapeutic course. Repeat another therapeutic course if it is necessary."
      ],
      "inactive_ingredient": [
        "8.0 mg of Metronidazole."
      ],
      "indications_and_usage": [
        "PHARMACOLOGY AND TOXICOLOGY Clindamycin Hydrochloride is a bacteriostatic antibiotic, which is 4 to 8 times more potent than Lincomycin. It has potent antibacterial activity to aerobic gram-positive bacterium, such as Staphylococcus, Streptococcus, Bacillus diphtheriae and Bacillus anthracis. It also has good antibacterial activity to anaerobic gram-negative bacterium. Bacteroides (including bacteroides fragilis) and Clostridium are morbidly susceptible to it. It binds exclusively to the 50'S subunit of sensitive bacterial ribosome and suppresses protein synthesis. Clindamycin is a bacteriostat, but can kill high sensitive bacterium at high concentration. Metronidazole is an anti-anaerobic bacterial, anti-trichomonal and anti-amebic agent. Combination of Clindamycin Hydrochloride and Metronidazole can kill Propionibacterium acnes, Pityrosporum ovale, and some other sensitive bacterium and vermiform mite, and can inhibit them from growing. As a result, it can reduce the creation of lipase, and prevent triacylglycerol from hydrolyzing into free fatty acid. INDICATIONS It is indicated for the treatment of acne (especially for the acne pustulosa, cystic acne), tympanitis, nasosinusitis, folliculitis, and other bacterial infection on skin. It is also indicated for the supportive treatment of seborrheic dermatitis and brandy nose."
      ],
      "keep_out_of_reach_of_children": [
        "WARNINGS: General: 1. If any irritation or other adverse reactions occurred, stop or reduce the drug, and consult a doctor. 2. It should not be used for long, because it may induce tolerance to bacterium. 3. Keep out of reach of children."
      ],
      "purpose": [
        "DESCRIPTION Acolorless or slightly yellow clear liquid; with an odour of alcohol. PHARMACOLOGY AND TOXICOLOGY Clindamycin Hydrochloride is a bacteriostatic antibiotic, which is 4 to 8 times more potent than Lincomycin. It has potent antibacterial activity to aerobic gram-positive bacterium, such as Staphylococcus, Streptococcus, Bacillus diphtheriae and Bacillus anthracis. It also has good antibacterial activity to anaerobic gram-negative bacterium. Bacteroides (including bacteroides fragilis) and Clostridium are morbidly susceptible to it. It binds exclusively to the 50'S subunit of sensitive bacterial ribosome and suppresses protein synthesis. Clindamycin is a bacteriostat, but can kill high sensitive bacterium at high concentration. Metronidazole is an anti-anaerobic bacterial, anti-trichomonal and anti-amebic agent. Combination of Clindamycin Hydrochloride and Metronidazole can kill Propionibacterium acnes, Pityrosporum ovale, and some other sensitive bacterium and vermiform mite, and can inhibit them from growing. As a result, it can reduce the creation of lipase, and prevent triacylglycerol from hydrolyzing into free fatty acid. INDICATIONS It is indicated for the treatment of acne (especially for the acne pustulosa, cystic acne), tympanitis, nasosinusitis, folliculitis, and other bacterial infection on skin. It is also indicated for the supportive treatment of seborrheic dermatitis and brandy nose. Drug Interactions: There is antagonism between ACNIL and erythromycin, so the combination of ACNIL and erythromycin is forbidden."
      ],
      "active_ingredient": [
        "It is a compound preparation. Each milliliter contains 10.0 mg of Clindamycin Hydrochloride (calculated as Clindamycin),"
      ],
      "package_label_principal_display_panel": [
        "Content of Labeling Package Label Acnil Content"
      ],
      "set_id": "178bf5ec-2282-cd65-e063-6294a90ae64b",
      "id": "2e5af775-2563-cb6c-e063-6294a90a6411",
      "effective_time": "20250217",
      "version": "3",
      "openfda": {
        "brand_name": [
          "Acnil"
        ],
        "generic_name": [
          "ACNIL CLINDAMYCIN HYDROCHLORIDE AND METRONIDAZOLE LINIMENT"
        ],
        "manufacturer_name": [
          "Jiangsu Chenpai Bond Pharmaceutical Co.,Ltd."
        ],
        "product_ndc": [
          "84277-5647"
        ],
        "product_type": [
          "HUMAN OTC DRUG"
        ],
        "route": [
          "TOPICAL"
        ],
        "substance_name": [
          "CLINDAMYCIN HYDROCHLORIDE",
          "METRONIDAZOLE"
        ],
        "spl_id": [
          "2e5af775-2563-cb6c-e063-6294a90a6411"
        ],
        "spl_set_id": [
          "178bf5ec-2282-cd65-e063-6294a90ae64b"
        ],
        "package_ndc": [
          "84277-5647-1"
        ],
        "is_original_packager": [
          true
        ],
        "nui": [
          "N0000175435",
          "M0014907"
        ],
        "pharm_class_epc": [
          "Nitroimidazole Antimicrobial [EPC]"
        ],
        "pharm_class_cs": [
          "Nitroimidazoles [CS]"
        ],
        "unii": [
          "T20OQ1YN1W",
          "140QMO216E"
        ]
      }
    }
  ]
}