{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 593
    },
    {
      "term": "FATIGUE",
      "count": 491
    },
    {
      "term": "NEUTROPENIA",
      "count": 450
    },
    {
      "term": "METASTASES TO BONE",
      "count": 392
    },
    {
      "term": "NAUSEA",
      "count": 330
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 315
    },
    {
      "term": "DIARRHOEA",
      "count": 289
    },
    {
      "term": "PAIN",
      "count": 263
    },
    {
      "term": "ARTHRALGIA",
      "count": 256
    },
    {
      "term": "HEADACHE",
      "count": 253
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 215
    },
    {
      "term": "OFF LABEL USE",
      "count": 207
    },
    {
      "term": "HOT FLUSH",
      "count": 193
    },
    {
      "term": "ASTHENIA",
      "count": 192
    },
    {
      "term": "BREAST CANCER",
      "count": 186
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 179
    },
    {
      "term": "DYSPNOEA",
      "count": 174
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 173
    },
    {
      "term": "VOMITING",
      "count": 170
    },
    {
      "term": "ALOPECIA",
      "count": 169
    },
    {
      "term": "ANAEMIA",
      "count": 165
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 164
    },
    {
      "term": "MALAISE",
      "count": 151
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 147
    },
    {
      "term": "DECREASED APPETITE",
      "count": 144
    },
    {
      "term": "DIZZINESS",
      "count": 139
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 139
    },
    {
      "term": "BACK PAIN",
      "count": 138
    },
    {
      "term": "CONSTIPATION",
      "count": 136
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 130
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 130
    },
    {
      "term": "INSOMNIA",
      "count": 124
    },
    {
      "term": "RASH",
      "count": 122
    },
    {
      "term": "PYREXIA",
      "count": 119
    },
    {
      "term": "BONE PAIN",
      "count": 116
    },
    {
      "term": "DEATH",
      "count": 112
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 111
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 110
    },
    {
      "term": "ANXIETY",
      "count": 109
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 109
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 104
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 104
    },
    {
      "term": "COUGH",
      "count": 102
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 97
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 92
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 91
    },
    {
      "term": "LEUKOPENIA",
      "count": 89
    },
    {
      "term": "DEPRESSION",
      "count": 87
    },
    {
      "term": "MYALGIA",
      "count": 87
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 86
    },
    {
      "term": "DECREASED IMMUNE RESPONSIVENESS",
      "count": 81
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 81
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 79
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 76
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 75
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 74
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 72
    },
    {
      "term": "HYPERTENSION",
      "count": 72
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 72
    },
    {
      "term": "ASCITES",
      "count": 69
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 69
    },
    {
      "term": "METASTASES TO SPINE",
      "count": 69
    },
    {
      "term": "STOMATITIS",
      "count": 69
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 67
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 66
    },
    {
      "term": "PARAESTHESIA",
      "count": 65
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 64
    },
    {
      "term": "DRY SKIN",
      "count": 64
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 64
    },
    {
      "term": "OSTEONECROSIS OF JAW",
      "count": 64
    },
    {
      "term": "PRURITUS",
      "count": 64
    },
    {
      "term": "DYSPEPSIA",
      "count": 63
    },
    {
      "term": "TUMOUR MARKER INCREASED",
      "count": 62
    },
    {
      "term": "BONE DISORDER",
      "count": 61
    },
    {
      "term": "CHEST PAIN",
      "count": 61
    },
    {
      "term": "PNEUMONIA",
      "count": 61
    },
    {
      "term": "JAUNDICE",
      "count": 60
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 58
    },
    {
      "term": "BONE LESION",
      "count": 58
    },
    {
      "term": "PNEUMONITIS",
      "count": 56
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 55
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 54
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 54
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 52
    },
    {
      "term": "INFLUENZA LIKE ILLNESS",
      "count": 52
    },
    {
      "term": "COVID-19",
      "count": 50
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 49
    },
    {
      "term": "BREAST MASS",
      "count": 48
    },
    {
      "term": "DEPRESSED MOOD",
      "count": 48
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 48
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 47
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 47
    },
    {
      "term": "MEMORY IMPAIRMENT",
      "count": 47
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 47
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 46
    },
    {
      "term": "FALL",
      "count": 46
    },
    {
      "term": "PALPITATIONS",
      "count": 46
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 46
    },
    {
      "term": "DISTURBANCE IN ATTENTION",
      "count": 45
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 45
    }
  ]
}