{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 907
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 885
    },
    {
      "term": "NEUTROPENIA",
      "count": 875
    },
    {
      "term": "OFF LABEL USE",
      "count": 807
    },
    {
      "term": "NAUSEA",
      "count": 698
    },
    {
      "term": "DIARRHOEA",
      "count": 612
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 569
    },
    {
      "term": "FATIGUE",
      "count": 559
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 528
    },
    {
      "term": "VOMITING",
      "count": 523
    },
    {
      "term": "ANAEMIA",
      "count": 517
    },
    {
      "term": "PYREXIA",
      "count": 483
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 452
    },
    {
      "term": "DYSPNOEA",
      "count": 432
    },
    {
      "term": "DEATH",
      "count": 398
    },
    {
      "term": "ASTHENIA",
      "count": 363
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 304
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 290
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 290
    },
    {
      "term": "PNEUMONIA",
      "count": 288
    },
    {
      "term": "COUGH",
      "count": 282
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 281
    },
    {
      "term": "METASTASES TO BONE",
      "count": 278
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 271
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 269
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 258
    },
    {
      "term": "DECREASED APPETITE",
      "count": 256
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 255
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 242
    },
    {
      "term": "LEUKOPENIA",
      "count": 239
    },
    {
      "term": "CONSTIPATION",
      "count": 235
    },
    {
      "term": "RASH",
      "count": 230
    },
    {
      "term": "PAIN",
      "count": 216
    },
    {
      "term": "BREAST CANCER",
      "count": 211
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 203
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 202
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 194
    },
    {
      "term": "SEPSIS",
      "count": 188
    },
    {
      "term": "HEADACHE",
      "count": 182
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 176
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 175
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 172
    },
    {
      "term": "NEUTROPENIC SEPSIS",
      "count": 171
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 169
    },
    {
      "term": "INFECTION",
      "count": 165
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 162
    },
    {
      "term": "ALOPECIA",
      "count": 161
    },
    {
      "term": "PANCYTOPENIA",
      "count": 159
    },
    {
      "term": "PNEUMONITIS",
      "count": 158
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 156
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 154
    },
    {
      "term": "ASCITES",
      "count": 149
    },
    {
      "term": "DIZZINESS",
      "count": 148
    },
    {
      "term": "OSTEONECROSIS OF JAW",
      "count": 148
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 144
    },
    {
      "term": "STOMATITIS",
      "count": 143
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 133
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 131
    },
    {
      "term": "BACK PAIN",
      "count": 129
    },
    {
      "term": "MALAISE",
      "count": 127
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 125
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 124
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 120
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 116
    },
    {
      "term": "DEHYDRATION",
      "count": 116
    },
    {
      "term": "HYPERTENSION",
      "count": 115
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 114
    },
    {
      "term": "CHEST PAIN",
      "count": 110
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 110
    },
    {
      "term": "PARAESTHESIA",
      "count": 107
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 106
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 103
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 103
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 103
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 102
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 100
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 98
    },
    {
      "term": "PRURITUS",
      "count": 97
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 95
    },
    {
      "term": "OSTEONECROSIS",
      "count": 94
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 93
    },
    {
      "term": "BLOOD LACTATE DEHYDROGENASE INCREASED",
      "count": 90
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 89
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 87
    },
    {
      "term": "HYPOTENSION",
      "count": 87
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 87
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 86
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 86
    },
    {
      "term": "ERYTHEMA",
      "count": 85
    },
    {
      "term": "DYSPNOEA EXERTIONAL",
      "count": 82
    },
    {
      "term": "NEUROTOXICITY",
      "count": 81
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 81
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 78
    },
    {
      "term": "ARTHRALGIA",
      "count": 77
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 77
    },
    {
      "term": "RENAL FAILURE",
      "count": 77
    },
    {
      "term": "DYSPHAGIA",
      "count": 76
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 76
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 75
    },
    {
      "term": "POLYNEUROPATHY",
      "count": 75
    }
  ]
}