{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "PYREXIA",
      "count": 320
    },
    {
      "term": "RASH",
      "count": 315
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 271
    },
    {
      "term": "DIARRHOEA",
      "count": 269
    },
    {
      "term": "ARTHRALGIA",
      "count": 217
    },
    {
      "term": "NAUSEA",
      "count": 207
    },
    {
      "term": "FATIGUE",
      "count": 202
    },
    {
      "term": "OFF LABEL USE",
      "count": 181
    },
    {
      "term": "VOMITING",
      "count": 158
    },
    {
      "term": "PHOTOSENSITIVITY REACTION",
      "count": 150
    },
    {
      "term": "ANAEMIA",
      "count": 146
    },
    {
      "term": "DEATH",
      "count": 131
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 126
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 116
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 114
    },
    {
      "term": "SKIN TOXICITY",
      "count": 114
    },
    {
      "term": "DYSPNOEA",
      "count": 103
    },
    {
      "term": "ASTHENIA",
      "count": 97
    },
    {
      "term": "PNEUMONIA",
      "count": 97
    },
    {
      "term": "DECREASED APPETITE",
      "count": 95
    },
    {
      "term": "HEADACHE",
      "count": 91
    },
    {
      "term": "ALOPECIA",
      "count": 84
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 84
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 84
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 80
    },
    {
      "term": "ERYTHEMA",
      "count": 79
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 78
    },
    {
      "term": "SQUAMOUS CELL CARCINOMA",
      "count": 78
    },
    {
      "term": "HYPERKERATOSIS",
      "count": 77
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 74
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 73
    },
    {
      "term": "NEUTROPENIA",
      "count": 72
    },
    {
      "term": "PRURITUS",
      "count": 72
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 71
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 70
    },
    {
      "term": "DEHYDRATION",
      "count": 69
    },
    {
      "term": "MYALGIA",
      "count": 69
    },
    {
      "term": "SQUAMOUS CELL CARCINOMA OF SKIN",
      "count": 68
    },
    {
      "term": "KERATOACANTHOMA",
      "count": 63
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 61
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 59
    },
    {
      "term": "UVEITIS",
      "count": 59
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 57
    },
    {
      "term": "CONSTIPATION",
      "count": 57
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 57
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 56
    },
    {
      "term": "RENAL FAILURE",
      "count": 56
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 54
    },
    {
      "term": "MALIGNANT MELANOMA",
      "count": 52
    },
    {
      "term": "SEPSIS",
      "count": 52
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 51
    },
    {
      "term": "DERMATITIS ACNEIFORM",
      "count": 51
    },
    {
      "term": "PAIN",
      "count": 50
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 48
    },
    {
      "term": "HYPERTENSION",
      "count": 47
    },
    {
      "term": "MALAISE",
      "count": 47
    },
    {
      "term": "SKIN PAPILLOMA",
      "count": 47
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 44
    },
    {
      "term": "COLITIS",
      "count": 44
    },
    {
      "term": "ERYTHEMA MULTIFORME",
      "count": 44
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 44
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 44
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 44
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 43
    },
    {
      "term": "INFECTION",
      "count": 42
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 41
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 41
    },
    {
      "term": "DYSPHAGIA",
      "count": 40
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 40
    },
    {
      "term": "PANCREATITIS",
      "count": 40
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 40
    },
    {
      "term": "COUGH",
      "count": 39
    },
    {
      "term": "DRUG ERUPTION",
      "count": 38
    },
    {
      "term": "DRUG INTERACTION",
      "count": 38
    },
    {
      "term": "PNEUMONITIS",
      "count": 38
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 38
    },
    {
      "term": "STEVENS-JOHNSON SYNDROME",
      "count": 38
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 36
    },
    {
      "term": "DYSGEUSIA",
      "count": 36
    },
    {
      "term": "HEPATITIS",
      "count": 36
    },
    {
      "term": "LEUKOPENIA",
      "count": 36
    },
    {
      "term": "METASTATIC MALIGNANT MELANOMA",
      "count": 36
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 35
    },
    {
      "term": "MELANOCYTIC NAEVUS",
      "count": 35
    },
    {
      "term": "RETINAL DETACHMENT",
      "count": 35
    },
    {
      "term": "CHILLS",
      "count": 34
    },
    {
      "term": "CHORIORETINOPATHY",
      "count": 34
    },
    {
      "term": "DRY SKIN",
      "count": 34
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 34
    },
    {
      "term": "HYPERTHYROIDISM",
      "count": 34
    },
    {
      "term": "PANNICULITIS",
      "count": 34
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 34
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 34
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 33
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 33
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 33
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 33
    },
    {
      "term": "TOXIC SKIN ERUPTION",
      "count": 33
    },
    {
      "term": "HYPOTENSION",
      "count": 32
    },
    {
      "term": "SYNCOPE",
      "count": 32
    }
  ]
}