{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1322
    },
    {
      "term": "HYPOTENSION",
      "count": 546
    },
    {
      "term": "OFF LABEL USE",
      "count": 529
    },
    {
      "term": "CARDIOGENIC SHOCK",
      "count": 408
    },
    {
      "term": "SEPSIS",
      "count": 407
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 389
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 374
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 330
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 327
    },
    {
      "term": "STRESS",
      "count": 312
    },
    {
      "term": "VOMITING",
      "count": 302
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 280
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 278
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 278
    },
    {
      "term": "ASCITES",
      "count": 269
    },
    {
      "term": "NAUSEA",
      "count": 268
    },
    {
      "term": "CARDIAC ARREST",
      "count": 266
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 263
    },
    {
      "term": "RENAL FAILURE",
      "count": 259
    },
    {
      "term": "DEATH",
      "count": 245
    },
    {
      "term": "CONSTIPATION",
      "count": 244
    },
    {
      "term": "APPENDICITIS",
      "count": 243
    },
    {
      "term": "APPENDICOLITH",
      "count": 241
    },
    {
      "term": "INTENTIONAL OVERDOSE",
      "count": 229
    },
    {
      "term": "VENTRICULAR FIBRILLATION",
      "count": 215
    },
    {
      "term": "SHOCK",
      "count": 207
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 204
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 202
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 195
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 187
    },
    {
      "term": "SOMNOLENCE",
      "count": 179
    },
    {
      "term": "LACTIC ACIDOSIS",
      "count": 178
    },
    {
      "term": "PAIN",
      "count": 176
    },
    {
      "term": "OVERDOSE",
      "count": 173
    },
    {
      "term": "ANAEMIA",
      "count": 168
    },
    {
      "term": "DYSPNOEA",
      "count": 160
    },
    {
      "term": "PNEUMONIA",
      "count": 155
    },
    {
      "term": "BLOOD PHOSPHORUS INCREASED",
      "count": 146
    },
    {
      "term": "DRY MOUTH",
      "count": 145
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 139
    },
    {
      "term": "BRADYCARDIA",
      "count": 137
    },
    {
      "term": "TACHYCARDIA",
      "count": 135
    },
    {
      "term": "INJURY",
      "count": 134
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 132
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 130
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 130
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 130
    },
    {
      "term": "BLOOD CHOLESTEROL INCREASED",
      "count": 129
    },
    {
      "term": "ANXIETY",
      "count": 128
    },
    {
      "term": "MULTI-ORGAN FAILURE",
      "count": 127
    },
    {
      "term": "BACTERIAL INFECTION",
      "count": 125
    },
    {
      "term": "INTENTIONAL PRODUCT MISUSE",
      "count": 125
    },
    {
      "term": "THROMBOSIS",
      "count": 125
    },
    {
      "term": "UNEVALUABLE EVENT",
      "count": 125
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 121
    },
    {
      "term": "HYPOXIA",
      "count": 120
    },
    {
      "term": "MYASTHENIA GRAVIS",
      "count": 119
    },
    {
      "term": "BLOOD URIC ACID INCREASED",
      "count": 116
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 116
    },
    {
      "term": "RENAL INJURY",
      "count": 115
    },
    {
      "term": "CHRONIC OBSTRUCTIVE PULMONARY DISEASE",
      "count": 114
    },
    {
      "term": "HYPERPHOSPHATAEMIA",
      "count": 114
    },
    {
      "term": "DRUG INTERACTION",
      "count": 113
    },
    {
      "term": "FEAR",
      "count": 113
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 112
    },
    {
      "term": "INCORRECT ROUTE OF PRODUCT ADMINISTRATION",
      "count": 111
    },
    {
      "term": "SWELLING",
      "count": 110
    },
    {
      "term": "HYPOPHOSPHATAEMIA",
      "count": 108
    },
    {
      "term": "NEURALGIA",
      "count": 106
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 100
    },
    {
      "term": "EMOTIONAL DISTRESS",
      "count": 100
    },
    {
      "term": "SLEEP DISORDER",
      "count": 99
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 98
    },
    {
      "term": "HYPERTENSION",
      "count": 96
    },
    {
      "term": "ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED",
      "count": 92
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 91
    },
    {
      "term": "PYREXIA",
      "count": 89
    },
    {
      "term": "ANHEDONIA",
      "count": 88
    },
    {
      "term": "IRON DEFICIENCY",
      "count": 87
    },
    {
      "term": "VASOPLEGIA SYNDROME",
      "count": 87
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 86
    },
    {
      "term": "HAEMODYNAMIC INSTABILITY",
      "count": 84
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 82
    },
    {
      "term": "ANALGESIC THERAPY",
      "count": 81
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 79
    },
    {
      "term": "PULMONARY OEDEMA",
      "count": 77
    },
    {
      "term": "DISTRIBUTIVE SHOCK",
      "count": 76
    },
    {
      "term": "DRUG THERAPY",
      "count": 76
    },
    {
      "term": "END STAGE RENAL DISEASE",
      "count": 76
    },
    {
      "term": "COMA",
      "count": 74
    },
    {
      "term": "DIABETES INSIPIDUS",
      "count": 72
    },
    {
      "term": "SLEEP DISORDER THERAPY",
      "count": 72
    },
    {
      "term": "HYPERLIPIDAEMIA",
      "count": 70
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 69
    },
    {
      "term": "GOUT",
      "count": 69
    },
    {
      "term": "HYPOGLYCAEMIA",
      "count": 69
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 65
    },
    {
      "term": "TROPONIN INCREASED",
      "count": 65
    },
    {
      "term": "DEPRESSED LEVEL OF CONSCIOUSNESS",
      "count": 64
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 64
    }
  ]
}