{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 3778
    },
    {
      "term": "DRUG INTERACTION",
      "count": 3605
    },
    {
      "term": "OFF LABEL USE",
      "count": 2159
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 2036
    },
    {
      "term": "SEIZURE",
      "count": 1966
    },
    {
      "term": "COMPLETED SUICIDE",
      "count": 1378
    },
    {
      "term": "SOMNOLENCE",
      "count": 1324
    },
    {
      "term": "DEPRESSION",
      "count": 1230
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 1136
    },
    {
      "term": "OVERDOSE",
      "count": 991
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 945
    },
    {
      "term": "PYREXIA",
      "count": 921
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 852
    },
    {
      "term": "STATUS EPILEPTICUS",
      "count": 771
    },
    {
      "term": "VOMITING",
      "count": 745
    },
    {
      "term": "FATIGUE",
      "count": 737
    },
    {
      "term": "HYPOTENSION",
      "count": 728
    },
    {
      "term": "TREMOR",
      "count": 710
    },
    {
      "term": "PNEUMONIA",
      "count": 706
    },
    {
      "term": "EPILEPSY",
      "count": 702
    },
    {
      "term": "AGGRESSION",
      "count": 698
    },
    {
      "term": "HYPERAMMONAEMIA",
      "count": 660
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 660
    },
    {
      "term": "AGITATION",
      "count": 654
    },
    {
      "term": "DEATH",
      "count": 652
    },
    {
      "term": "NAUSEA",
      "count": 619
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 613
    },
    {
      "term": "ANXIETY",
      "count": 603
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 601
    },
    {
      "term": "FALL",
      "count": 588
    },
    {
      "term": "CONVULSION",
      "count": 576
    },
    {
      "term": "COMA",
      "count": 562
    },
    {
      "term": "INTENTIONAL OVERDOSE",
      "count": 562
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 561
    },
    {
      "term": "DIZZINESS",
      "count": 551
    },
    {
      "term": "DEPRESSED LEVEL OF CONSCIOUSNESS",
      "count": 547
    },
    {
      "term": "NEUROLEPTIC MALIGNANT SYNDROME",
      "count": 537
    },
    {
      "term": "MULTIPLE-DRUG RESISTANCE",
      "count": 536
    },
    {
      "term": "HYPERAMMONAEMIC ENCEPHALOPATHY",
      "count": 513
    },
    {
      "term": "NEUTROPENIA",
      "count": 510
    },
    {
      "term": "DIARRHOEA",
      "count": 504
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 503
    },
    {
      "term": "PSYCHOTIC DISORDER",
      "count": 499
    },
    {
      "term": "RASH",
      "count": 485
    },
    {
      "term": "INSOMNIA",
      "count": 484
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 473
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 461
    },
    {
      "term": "GENERALISED TONIC-CLONIC SEIZURE",
      "count": 458
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 455
    },
    {
      "term": "COGNITIVE DISORDER",
      "count": 443
    },
    {
      "term": "HEADACHE",
      "count": 442
    },
    {
      "term": "CARDIAC ARREST",
      "count": 440
    },
    {
      "term": "SEDATION",
      "count": 437
    },
    {
      "term": "SUICIDE ATTEMPT",
      "count": 436
    },
    {
      "term": "SUICIDAL IDEATION",
      "count": 426
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 421
    },
    {
      "term": "DECREASED APPETITE",
      "count": 412
    },
    {
      "term": "ASTHENIA",
      "count": 410
    },
    {
      "term": "DELIRIUM",
      "count": 405
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 391
    },
    {
      "term": "ABNORMAL BEHAVIOUR",
      "count": 388
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 379
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 375
    },
    {
      "term": "TREATMENT NONCOMPLIANCE",
      "count": 374
    },
    {
      "term": "TACHYCARDIA",
      "count": 372
    },
    {
      "term": "MALAISE",
      "count": 370
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 368
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 365
    },
    {
      "term": "DYSPNOEA",
      "count": 363
    },
    {
      "term": "DYSARTHRIA",
      "count": 354
    },
    {
      "term": "IRRITABILITY",
      "count": 349
    },
    {
      "term": "LOSS OF CONSCIOUSNESS",
      "count": 349
    },
    {
      "term": "CARDIO-RESPIRATORY ARREST",
      "count": 336
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 334
    },
    {
      "term": "DRUG ABUSE",
      "count": 323
    },
    {
      "term": "MENTAL STATUS CHANGES",
      "count": 323
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 322
    },
    {
      "term": "LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES",
      "count": 317
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 316
    },
    {
      "term": "PAIN",
      "count": 316
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 315
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 309
    },
    {
      "term": "ATAXIA",
      "count": 308
    },
    {
      "term": "PARKINSONISM",
      "count": 305
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 304
    },
    {
      "term": "HYPERTENSION",
      "count": 304
    },
    {
      "term": "EXTRAPYRAMIDAL DISORDER",
      "count": 302
    },
    {
      "term": "SPEECH DISORDER",
      "count": 299
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 293
    },
    {
      "term": "LEUKOPENIA",
      "count": 292
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 291
    },
    {
      "term": "DISORIENTATION",
      "count": 290
    },
    {
      "term": "EXPOSURE DURING PREGNANCY",
      "count": 287
    },
    {
      "term": "DISTURBANCE IN ATTENTION",
      "count": 286
    },
    {
      "term": "PETIT MAL EPILEPSY",
      "count": 286
    },
    {
      "term": "LETHARGY",
      "count": 285
    },
    {
      "term": "PNEUMONIA ASPIRATION",
      "count": 274
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 271
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 269
    },
    {
      "term": "CONSTIPATION",
      "count": 267
    }
  ]
}