{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "PYREXIA",
      "count": 1255
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 902
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 391
    },
    {
      "term": "DIARRHOEA",
      "count": 376
    },
    {
      "term": "OFF LABEL USE",
      "count": 362
    },
    {
      "term": "RASH",
      "count": 341
    },
    {
      "term": "NAUSEA",
      "count": 334
    },
    {
      "term": "VOMITING",
      "count": 319
    },
    {
      "term": "FATIGUE",
      "count": 300
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 278
    },
    {
      "term": "DEATH",
      "count": 277
    },
    {
      "term": "CHILLS",
      "count": 258
    },
    {
      "term": "METASTATIC MALIGNANT MELANOMA",
      "count": 211
    },
    {
      "term": "ASTHENIA",
      "count": 206
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 202
    },
    {
      "term": "HEADACHE",
      "count": 194
    },
    {
      "term": "ANAEMIA",
      "count": 176
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 176
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 171
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 158
    },
    {
      "term": "PNEUMONIA",
      "count": 155
    },
    {
      "term": "DECREASED APPETITE",
      "count": 154
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 152
    },
    {
      "term": "NEUTROPENIA",
      "count": 152
    },
    {
      "term": "DYSPNOEA",
      "count": 149
    },
    {
      "term": "ARTHRALGIA",
      "count": 148
    },
    {
      "term": "HYPOTENSION",
      "count": 144
    },
    {
      "term": "MALIGNANT MELANOMA",
      "count": 143
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 138
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 135
    },
    {
      "term": "DEHYDRATION",
      "count": 128
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 123
    },
    {
      "term": "SEPSIS",
      "count": 119
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 118
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 117
    },
    {
      "term": "UVEITIS",
      "count": 109
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 105
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 104
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 104
    },
    {
      "term": "MALAISE",
      "count": 98
    },
    {
      "term": "COUGH",
      "count": 97
    },
    {
      "term": "HYPERTENSION",
      "count": 97
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 97
    },
    {
      "term": "PAIN",
      "count": 96
    },
    {
      "term": "CONSTIPATION",
      "count": 93
    },
    {
      "term": "DERMATITIS ACNEIFORM",
      "count": 91
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 86
    },
    {
      "term": "SKIN TOXICITY",
      "count": 84
    },
    {
      "term": "MYALGIA",
      "count": 82
    },
    {
      "term": "PNEUMONITIS",
      "count": 82
    },
    {
      "term": "INFECTION",
      "count": 81
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 81
    },
    {
      "term": "SEIZURE",
      "count": 80
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 79
    },
    {
      "term": "BLOOD LACTATE DEHYDROGENASE INCREASED",
      "count": 79
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 78
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 78
    },
    {
      "term": "PRURITUS",
      "count": 76
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 72
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 71
    },
    {
      "term": "DRY SKIN",
      "count": 70
    },
    {
      "term": "PANNICULITIS",
      "count": 67
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 66
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 66
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 66
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 65
    },
    {
      "term": "RENAL FAILURE",
      "count": 65
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 65
    },
    {
      "term": "COLITIS",
      "count": 64
    },
    {
      "term": "DYSPHAGIA",
      "count": 64
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 64
    },
    {
      "term": "DIZZINESS",
      "count": 63
    },
    {
      "term": "LEUKOPENIA",
      "count": 63
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 63
    },
    {
      "term": "VISION BLURRED",
      "count": 63
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 61
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 61
    },
    {
      "term": "HEPATITIS",
      "count": 60
    },
    {
      "term": "PARONYCHIA",
      "count": 60
    },
    {
      "term": "ALOPECIA",
      "count": 59
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 59
    },
    {
      "term": "BASAL CELL CARCINOMA",
      "count": 58
    },
    {
      "term": "OEDEMA",
      "count": 58
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 57
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 57
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 57
    },
    {
      "term": "SYNCOPE",
      "count": 56
    },
    {
      "term": "BACK PAIN",
      "count": 55
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 55
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 55
    },
    {
      "term": "DERMATITIS",
      "count": 54
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 54
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 54
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 52
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 51
    },
    {
      "term": "SQUAMOUS CELL CARCINOMA",
      "count": 51
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 50
    },
    {
      "term": "ECZEMA",
      "count": 49
    },
    {
      "term": "ERYTHEMA",
      "count": 49
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 49
    }
  ]
}