{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 546
    },
    {
      "term": "OFF LABEL USE",
      "count": 544
    },
    {
      "term": "NEUTROPENIA",
      "count": 496
    },
    {
      "term": "ANAEMIA",
      "count": 432
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 392
    },
    {
      "term": "PYREXIA",
      "count": 380
    },
    {
      "term": "VOMITING",
      "count": 379
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 378
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 359
    },
    {
      "term": "NAUSEA",
      "count": 317
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 311
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 267
    },
    {
      "term": "DIARRHOEA",
      "count": 262
    },
    {
      "term": "FATIGUE",
      "count": 253
    },
    {
      "term": "PANCYTOPENIA",
      "count": 249
    },
    {
      "term": "DEATH",
      "count": 206
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 178
    },
    {
      "term": "DYSPNOEA",
      "count": 177
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 177
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 171
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 147
    },
    {
      "term": "PAIN",
      "count": 144
    },
    {
      "term": "ASTHENIA",
      "count": 142
    },
    {
      "term": "DEHYDRATION",
      "count": 136
    },
    {
      "term": "PNEUMONIA",
      "count": 136
    },
    {
      "term": "LEUKOPENIA",
      "count": 135
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 134
    },
    {
      "term": "SEPSIS",
      "count": 134
    },
    {
      "term": "HYPOTENSION",
      "count": 131
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 130
    },
    {
      "term": "ASCITES",
      "count": 125
    },
    {
      "term": "DECREASED APPETITE",
      "count": 118
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 114
    },
    {
      "term": "HEADACHE",
      "count": 112
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 111
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 107
    },
    {
      "term": "INFECTION",
      "count": 101
    },
    {
      "term": "CONSTIPATION",
      "count": 98
    },
    {
      "term": "HYPERTENSION",
      "count": 98
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 95
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 91
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 88
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 87
    },
    {
      "term": "CHILLS",
      "count": 84
    },
    {
      "term": "BACK PAIN",
      "count": 83
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 83
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 82
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 80
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 79
    },
    {
      "term": "COUGH",
      "count": 79
    },
    {
      "term": "TACHYCARDIA",
      "count": 75
    },
    {
      "term": "EPISTAXIS",
      "count": 74
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 73
    },
    {
      "term": "LYMPHOPENIA",
      "count": 72
    },
    {
      "term": "RENAL FAILURE",
      "count": 71
    },
    {
      "term": "METASTASES TO BONE",
      "count": 69
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 68
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 66
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 66
    },
    {
      "term": "BRONCHOSPASM",
      "count": 64
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 64
    },
    {
      "term": "BODY TEMPERATURE INCREASED",
      "count": 61
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 59
    },
    {
      "term": "MALAISE",
      "count": 59
    },
    {
      "term": "DIZZINESS",
      "count": 58
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 58
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 57
    },
    {
      "term": "RASH",
      "count": 55
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 54
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 54
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 53
    },
    {
      "term": "MENTAL STATUS CHANGES",
      "count": 53
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 53
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 52
    },
    {
      "term": "ILEUS",
      "count": 51
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 50
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 50
    },
    {
      "term": "NEUROBLASTOMA",
      "count": 49
    },
    {
      "term": "OVARIAN CANCER",
      "count": 49
    },
    {
      "term": "VITREOUS HAEMORRHAGE",
      "count": 49
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 48
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 48
    },
    {
      "term": "HYDRONEPHROSIS",
      "count": 48
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 48
    },
    {
      "term": "DRUG TOXICITY",
      "count": 47
    },
    {
      "term": "PROCTALGIA",
      "count": 47
    },
    {
      "term": "HYPOXIA",
      "count": 46
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 44
    },
    {
      "term": "HAEMATURIA",
      "count": 44
    },
    {
      "term": "HAEMORRHOIDS",
      "count": 44
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 43
    },
    {
      "term": "CHEST PAIN",
      "count": 43
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 43
    },
    {
      "term": "STOMATITIS",
      "count": 43
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 42
    },
    {
      "term": "NEOPLASM RECURRENCE",
      "count": 42
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 41
    },
    {
      "term": "DESMOPLASTIC SMALL ROUND CELL TUMOUR",
      "count": 41
    },
    {
      "term": "SOMNOLENCE",
      "count": 41
    },
    {
      "term": "ACCIDENT",
      "count": 40
    }
  ]
}