{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 12950
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 8707
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 5970
    },
    {
      "term": "DRUG INTERACTION",
      "count": 5658
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 5295
    },
    {
      "term": "DIARRHOEA",
      "count": 4656
    },
    {
      "term": "TRANSPLANT REJECTION",
      "count": 4144
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 4050
    },
    {
      "term": "PYREXIA",
      "count": 3947
    },
    {
      "term": "COVID-19",
      "count": 3718
    },
    {
      "term": "PNEUMONIA",
      "count": 3628
    },
    {
      "term": "DEATH",
      "count": 3627
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 3600
    },
    {
      "term": "SEPSIS",
      "count": 2897
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 2881
    },
    {
      "term": "POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER",
      "count": 2859
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 2696
    },
    {
      "term": "NAUSEA",
      "count": 2595
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 2430
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 2397
    },
    {
      "term": "ANAEMIA",
      "count": 2322
    },
    {
      "term": "VOMITING",
      "count": 2275
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 2266
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 2170
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 2157
    },
    {
      "term": "RENAL FAILURE",
      "count": 2105
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 2078
    },
    {
      "term": "HEADACHE",
      "count": 2029
    },
    {
      "term": "NEUTROPENIA",
      "count": 2022
    },
    {
      "term": "DYSPNOEA",
      "count": 1977
    },
    {
      "term": "INFECTION",
      "count": 1960
    },
    {
      "term": "FATIGUE",
      "count": 1910
    },
    {
      "term": "LEUKOPENIA",
      "count": 1896
    },
    {
      "term": "HYPERTENSION",
      "count": 1881
    },
    {
      "term": "IMMUNOSUPPRESSANT DRUG LEVEL INCREASED",
      "count": 1876
    },
    {
      "term": "RASH",
      "count": 1847
    },
    {
      "term": "KIDNEY TRANSPLANT REJECTION",
      "count": 1798
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 1749
    },
    {
      "term": "PANCYTOPENIA",
      "count": 1704
    },
    {
      "term": "POLYOMAVIRUS-ASSOCIATED NEPHROPATHY",
      "count": 1677
    },
    {
      "term": "CYTOMEGALOVIRUS VIRAEMIA",
      "count": 1639
    },
    {
      "term": "PRURITUS",
      "count": 1635
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 1577
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 1558
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 1516
    },
    {
      "term": "EPSTEIN-BARR VIRUS INFECTION",
      "count": 1480
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 1465
    },
    {
      "term": "TREMOR",
      "count": 1381
    },
    {
      "term": "BK VIRUS INFECTION",
      "count": 1374
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 1350
    },
    {
      "term": "POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME",
      "count": 1288
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 1243
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 1235
    },
    {
      "term": "PAIN",
      "count": 1232
    },
    {
      "term": "ASTHENIA",
      "count": 1220
    },
    {
      "term": "COUGH",
      "count": 1213
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 1212
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 1190
    },
    {
      "term": "PNEUMOCYSTIS JIROVECII PNEUMONIA",
      "count": 1178
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 1130
    },
    {
      "term": "HYPOTENSION",
      "count": 1115
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION REACTIVATION",
      "count": 1109
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 1098
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE",
      "count": 1093
    },
    {
      "term": "COMPLICATIONS OF TRANSPLANTED KIDNEY",
      "count": 1092
    },
    {
      "term": "MALAISE",
      "count": 1092
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 1086
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 1074
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 1064
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 1042
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 1042
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 1017
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 998
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 974
    },
    {
      "term": "DECREASED APPETITE",
      "count": 973
    },
    {
      "term": "ARTHRALGIA",
      "count": 958
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 955
    },
    {
      "term": "CHRONIC GRAFT VERSUS HOST DISEASE",
      "count": 952
    },
    {
      "term": "HYPERKALAEMIA",
      "count": 940
    },
    {
      "term": "NOCARDIOSIS",
      "count": 940
    },
    {
      "term": "PSEUDOMONAS INFECTION",
      "count": 926
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 911
    },
    {
      "term": "EXPOSURE DURING PREGNANCY",
      "count": 909
    },
    {
      "term": "KLEBSIELLA INFECTION",
      "count": 900
    },
    {
      "term": "DERMATITIS ATOPIC",
      "count": 890
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 887
    },
    {
      "term": "ENTEROCOCCAL INFECTION",
      "count": 880
    },
    {
      "term": "TRANSPLANT DYSFUNCTION",
      "count": 879
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 877
    },
    {
      "term": "ESCHERICHIA INFECTION",
      "count": 862
    },
    {
      "term": "ERYTHEMA",
      "count": 857
    },
    {
      "term": "ADENOVIRUS INFECTION",
      "count": 846
    },
    {
      "term": "DEHYDRATION",
      "count": 846
    },
    {
      "term": "KAPOSI^S SARCOMA",
      "count": 838
    },
    {
      "term": "NEUROTOXICITY",
      "count": 838
    },
    {
      "term": "PROTEINURIA",
      "count": 808
    },
    {
      "term": "DIZZINESS",
      "count": 807
    },
    {
      "term": "HOSPITALISATION",
      "count": 804
    },
    {
      "term": "BACTERAEMIA",
      "count": 800
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE IN SKIN",
      "count": 795
    }
  ]
}