{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 28994
    },
    {
      "term": "RHEUMATOID ARTHRITIS",
      "count": 19226
    },
    {
      "term": "PAIN",
      "count": 15759
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 13646
    },
    {
      "term": "ARTHRALGIA",
      "count": 13197
    },
    {
      "term": "FATIGUE",
      "count": 13142
    },
    {
      "term": "JOINT SWELLING",
      "count": 12594
    },
    {
      "term": "OFF LABEL USE",
      "count": 10895
    },
    {
      "term": "RASH",
      "count": 10732
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 9925
    },
    {
      "term": "CONTRAINDICATED PRODUCT ADMINISTERED",
      "count": 9531
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 9446
    },
    {
      "term": "ALOPECIA",
      "count": 9381
    },
    {
      "term": "ARTHROPATHY",
      "count": 9103
    },
    {
      "term": "SYNOVITIS",
      "count": 9052
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 8784
    },
    {
      "term": "SYSTEMIC LUPUS ERYTHEMATOSUS",
      "count": 8710
    },
    {
      "term": "SWELLING",
      "count": 8583
    },
    {
      "term": "NAUSEA",
      "count": 8412
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 8195
    },
    {
      "term": "PEMPHIGUS",
      "count": 7931
    },
    {
      "term": "GLOSSODYNIA",
      "count": 7702
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 7486
    },
    {
      "term": "HAND DEFORMITY",
      "count": 7384
    },
    {
      "term": "MUSCULOSKELETAL STIFFNESS",
      "count": 7378
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 7185
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 6910
    },
    {
      "term": "HEADACHE",
      "count": 6873
    },
    {
      "term": "WOUND",
      "count": 6824
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT DECREASED",
      "count": 6656
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 6610
    },
    {
      "term": "DIARRHOEA",
      "count": 6357
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 5983
    },
    {
      "term": "PERICARDITIS",
      "count": 5855
    },
    {
      "term": "PSORIATIC ARTHROPATHY",
      "count": 5816
    },
    {
      "term": "DISCOMFORT",
      "count": 5740
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 5717
    },
    {
      "term": "VOMITING",
      "count": 5647
    },
    {
      "term": "INFECTION",
      "count": 5606
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 5503
    },
    {
      "term": "ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE",
      "count": 5481
    },
    {
      "term": "MALAISE",
      "count": 5330
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 5308
    },
    {
      "term": "DYSPNOEA",
      "count": 5136
    },
    {
      "term": "PYREXIA",
      "count": 5103
    },
    {
      "term": "HYPERTENSION",
      "count": 5017
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 4921
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 4836
    },
    {
      "term": "MOBILITY DECREASED",
      "count": 4756
    },
    {
      "term": "PRURITUS",
      "count": 4635
    },
    {
      "term": "HELICOBACTER INFECTION",
      "count": 4626
    },
    {
      "term": "DUODENAL ULCER PERFORATION",
      "count": 4603
    },
    {
      "term": "PNEUMONIA",
      "count": 4549
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 4336
    },
    {
      "term": "STOMATITIS",
      "count": 4249
    },
    {
      "term": "BLISTER",
      "count": 4192
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 4190
    },
    {
      "term": "RHEUMATOID FACTOR POSITIVE",
      "count": 4066
    },
    {
      "term": "DIZZINESS",
      "count": 4061
    },
    {
      "term": "SINUSITIS",
      "count": 4017
    },
    {
      "term": "IMPAIRED HEALING",
      "count": 3994
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 3933
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 3910
    },
    {
      "term": "IRRITABLE BOWEL SYNDROME",
      "count": 3796
    },
    {
      "term": "FOLLICULITIS",
      "count": 3775
    },
    {
      "term": "LOWER RESPIRATORY TRACT INFECTION",
      "count": 3771
    },
    {
      "term": "INFLAMMATION",
      "count": 3707
    },
    {
      "term": "OSTEOARTHRITIS",
      "count": 3658
    },
    {
      "term": "LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES",
      "count": 3626
    },
    {
      "term": "TYPE 2 DIABETES MELLITUS",
      "count": 3569
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 3557
    },
    {
      "term": "BLOOD CHOLESTEROL INCREASED",
      "count": 3515
    },
    {
      "term": "C-REACTIVE PROTEIN ABNORMAL",
      "count": 3515
    },
    {
      "term": "URTICARIA",
      "count": 3441
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 3416
    },
    {
      "term": "FIBROMYALGIA",
      "count": 3392
    },
    {
      "term": "ARTHRITIS",
      "count": 3377
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 3369
    },
    {
      "term": "CONTUSION",
      "count": 3327
    },
    {
      "term": "MUSCLE INJURY",
      "count": 3288
    },
    {
      "term": "ILL-DEFINED DISORDER",
      "count": 3271
    },
    {
      "term": "INSOMNIA",
      "count": 3271
    },
    {
      "term": "ASTHENIA",
      "count": 3234
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 3095
    },
    {
      "term": "INJURY",
      "count": 3059
    },
    {
      "term": "LIVER INJURY",
      "count": 2995
    },
    {
      "term": "MUSCULOSKELETAL PAIN",
      "count": 2988
    },
    {
      "term": "RHEUMATIC FEVER",
      "count": 2967
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 2924
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 2924
    },
    {
      "term": "SLEEP DISORDER",
      "count": 2861
    },
    {
      "term": "DECREASED APPETITE",
      "count": 2773
    },
    {
      "term": "SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE",
      "count": 2750
    },
    {
      "term": "WHEEZING",
      "count": 2598
    },
    {
      "term": "DEPRESSION",
      "count": 2559
    },
    {
      "term": "JOINT RANGE OF MOTION DECREASED",
      "count": 2512
    },
    {
      "term": "RED BLOOD CELL SEDIMENTATION RATE INCREASED",
      "count": 2501
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 2355
    },
    {
      "term": "PSORIASIS",
      "count": 2344
    },
    {
      "term": "CHEST PAIN",
      "count": 2317
    }
  ]
}