{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 1995
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1079
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 769
    },
    {
      "term": "DIARRHOEA",
      "count": 552
    },
    {
      "term": "PYREXIA",
      "count": 550
    },
    {
      "term": "PNEUMONIA",
      "count": 502
    },
    {
      "term": "DRUG INTERACTION",
      "count": 452
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 429
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 377
    },
    {
      "term": "TRANSPLANT REJECTION",
      "count": 371
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 350
    },
    {
      "term": "DEATH",
      "count": 334
    },
    {
      "term": "NAUSEA",
      "count": 324
    },
    {
      "term": "SEPSIS",
      "count": 315
    },
    {
      "term": "INFECTION",
      "count": 310
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 310
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 305
    },
    {
      "term": "FATIGUE",
      "count": 281
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 278
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 277
    },
    {
      "term": "VOMITING",
      "count": 267
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 262
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 258
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 258
    },
    {
      "term": "NEUTROPENIA",
      "count": 256
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 254
    },
    {
      "term": "ANAEMIA",
      "count": 249
    },
    {
      "term": "HEADACHE",
      "count": 240
    },
    {
      "term": "DYSPNOEA",
      "count": 237
    },
    {
      "term": "EPSTEIN-BARR VIRUS INFECTION",
      "count": 237
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 220
    },
    {
      "term": "POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER",
      "count": 216
    },
    {
      "term": "CHRONIC GRAFT VERSUS HOST DISEASE",
      "count": 215
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 213
    },
    {
      "term": "COVID-19",
      "count": 212
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 208
    },
    {
      "term": "RENAL FAILURE",
      "count": 204
    },
    {
      "term": "HYPERTENSION",
      "count": 203
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 203
    },
    {
      "term": "MOUTH ULCERATION",
      "count": 199
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE",
      "count": 198
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 197
    },
    {
      "term": "POLYOMAVIRUS-ASSOCIATED NEPHROPATHY",
      "count": 196
    },
    {
      "term": "KIDNEY TRANSPLANT REJECTION",
      "count": 193
    },
    {
      "term": "STOMATITIS",
      "count": 189
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 183
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION REACTIVATION",
      "count": 175
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 166
    },
    {
      "term": "COUGH",
      "count": 166
    },
    {
      "term": "LEUKOPENIA",
      "count": 161
    },
    {
      "term": "PAIN",
      "count": 158
    },
    {
      "term": "PANCYTOPENIA",
      "count": 158
    },
    {
      "term": "ASTHENIA",
      "count": 157
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 154
    },
    {
      "term": "BK VIRUS INFECTION",
      "count": 153
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 151
    },
    {
      "term": "ADENOVIRUS INFECTION",
      "count": 148
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 148
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 144
    },
    {
      "term": "RASH",
      "count": 142
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 140
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 138
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 137
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 136
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 133
    },
    {
      "term": "PROTEINURIA",
      "count": 131
    },
    {
      "term": "CYTOMEGALOVIRUS VIRAEMIA",
      "count": 129
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 127
    },
    {
      "term": "IMMUNOSUPPRESSANT DRUG LEVEL INCREASED",
      "count": 123
    },
    {
      "term": "HYPERTRIGLYCERIDAEMIA",
      "count": 120
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 118
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 117
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 117
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE IN SKIN",
      "count": 115
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 113
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 113
    },
    {
      "term": "DECREASED APPETITE",
      "count": 112
    },
    {
      "term": "SQUAMOUS CELL CARCINOMA OF SKIN",
      "count": 110
    },
    {
      "term": "POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME",
      "count": 107
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE IN GASTROINTESTINAL TRACT",
      "count": 106
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 106
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE IN SKIN",
      "count": 105
    },
    {
      "term": "KAPOSI^S SARCOMA",
      "count": 105
    },
    {
      "term": "PRURITUS",
      "count": 104
    },
    {
      "term": "HYPOTENSION",
      "count": 103
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 102
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 100
    },
    {
      "term": "TRANSPLANT FAILURE",
      "count": 100
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 100
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 99
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 98
    },
    {
      "term": "PNEUMOCYSTIS JIROVECII PNEUMONIA",
      "count": 98
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 95
    },
    {
      "term": "DEHYDRATION",
      "count": 94
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 94
    },
    {
      "term": "PNEUMONITIS",
      "count": 93
    },
    {
      "term": "PULMONARY TOXICITY",
      "count": 93
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 92
    },
    {
      "term": "SQUAMOUS CELL CARCINOMA",
      "count": 92
    },
    {
      "term": "CELLULITIS",
      "count": 91
    }
  ]
}