{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 128
    },
    {
      "term": "OFF LABEL USE",
      "count": 105
    },
    {
      "term": "PAIN",
      "count": 101
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 85
    },
    {
      "term": "FATIGUE",
      "count": 82
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 80
    },
    {
      "term": "DEATH",
      "count": 70
    },
    {
      "term": "DIARRHOEA",
      "count": 68
    },
    {
      "term": "NAUSEA",
      "count": 67
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 66
    },
    {
      "term": "ANXIETY",
      "count": 61
    },
    {
      "term": "PNEUMONIA",
      "count": 61
    },
    {
      "term": "RASH",
      "count": 61
    },
    {
      "term": "RENAL FAILURE",
      "count": 57
    },
    {
      "term": "ARTHRALGIA",
      "count": 55
    },
    {
      "term": "FALL",
      "count": 55
    },
    {
      "term": "DYSPNOEA",
      "count": 49
    },
    {
      "term": "VOMITING",
      "count": 48
    },
    {
      "term": "HEADACHE",
      "count": 47
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 46
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 46
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 45
    },
    {
      "term": "ASTHENIA",
      "count": 43
    },
    {
      "term": "PYREXIA",
      "count": 41
    },
    {
      "term": "DIZZINESS",
      "count": 40
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 39
    },
    {
      "term": "DEPRESSION",
      "count": 38
    },
    {
      "term": "EMOTIONAL DISTRESS",
      "count": 38
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 36
    },
    {
      "term": "ANAEMIA",
      "count": 35
    },
    {
      "term": "COUGH",
      "count": 35
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 35
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 35
    },
    {
      "term": "CELLULITIS",
      "count": 34
    },
    {
      "term": "BACK PAIN",
      "count": 33
    },
    {
      "term": "PRURITUS",
      "count": 33
    },
    {
      "term": "END STAGE RENAL DISEASE",
      "count": 32
    },
    {
      "term": "BLISTER",
      "count": 31
    },
    {
      "term": "DECREASED APPETITE",
      "count": 30
    },
    {
      "term": "CONSTIPATION",
      "count": 29
    },
    {
      "term": "MALAISE",
      "count": 29
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 29
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 28
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 28
    },
    {
      "term": "SKIN ULCER",
      "count": 28
    },
    {
      "term": "ANHEDONIA",
      "count": 27
    },
    {
      "term": "HYPOTENSION",
      "count": 27
    },
    {
      "term": "DEHYDRATION",
      "count": 26
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 26
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 25
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 25
    },
    {
      "term": "INSOMNIA",
      "count": 25
    },
    {
      "term": "SKIN DISCOLOURATION",
      "count": 25
    },
    {
      "term": "HYPERTENSION",
      "count": 23
    },
    {
      "term": "BURNING SENSATION",
      "count": 22
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 22
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 22
    },
    {
      "term": "SKIN EXFOLIATION",
      "count": 22
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 22
    },
    {
      "term": "BALANCE DISORDER",
      "count": 21
    },
    {
      "term": "GASTROOESOPHAGEAL REFLUX DISEASE",
      "count": 21
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 21
    },
    {
      "term": "JOINT SWELLING",
      "count": 21
    },
    {
      "term": "SEPSIS",
      "count": 21
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 20
    },
    {
      "term": "ERYTHEMA",
      "count": 20
    },
    {
      "term": "IMPAIRED HEALING",
      "count": 20
    },
    {
      "term": "BLOOD GLUCOSE INCREASED",
      "count": 19
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 19
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 19
    },
    {
      "term": "EPISTAXIS",
      "count": 19
    },
    {
      "term": "OROPHARYNGEAL PAIN",
      "count": 19
    },
    {
      "term": "OXYGEN SATURATION DECREASED",
      "count": 19
    },
    {
      "term": "CHEST PAIN",
      "count": 18
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 18
    },
    {
      "term": "INJURY",
      "count": 18
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 18
    },
    {
      "term": "SOMNOLENCE",
      "count": 18
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 17
    },
    {
      "term": "VISION BLURRED",
      "count": 17
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 17
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 16
    },
    {
      "term": "DISCOMFORT",
      "count": 16
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 16
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 16
    },
    {
      "term": "INFECTION",
      "count": 16
    },
    {
      "term": "MYALGIA",
      "count": 16
    },
    {
      "term": "ECONOMIC PROBLEM",
      "count": 15
    },
    {
      "term": "ILLNESS",
      "count": 15
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 15
    },
    {
      "term": "RENAL INJURY",
      "count": 15
    },
    {
      "term": "THERMAL BURN",
      "count": 15
    },
    {
      "term": "CARDIAC FAILURE CONGESTIVE",
      "count": 14
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 14
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 14
    },
    {
      "term": "MEMORY IMPAIRMENT",
      "count": 14
    },
    {
      "term": "TACHYCARDIA",
      "count": 14
    },
    {
      "term": "BLOOD PRESSURE SYSTOLIC INCREASED",
      "count": 13
    },
    {
      "term": "BONE DENSITY DECREASED",
      "count": 13
    },
    {
      "term": "BONE PAIN",
      "count": 13
    }
  ]
}