{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "CONSTIPATION",
      "count": 193
    },
    {
      "term": "DIARRHOEA",
      "count": 133
    },
    {
      "term": "NAUSEA",
      "count": 114
    },
    {
      "term": "PRURITUS",
      "count": 101
    },
    {
      "term": "VOMITING",
      "count": 88
    },
    {
      "term": "DEATH",
      "count": 86
    },
    {
      "term": "END STAGE RENAL DISEASE",
      "count": 79
    },
    {
      "term": "RENAL FAILURE",
      "count": 78
    },
    {
      "term": "FATIGUE",
      "count": 77
    },
    {
      "term": "DYSPNOEA",
      "count": 76
    },
    {
      "term": "OFF LABEL USE",
      "count": 71
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 68
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 63
    },
    {
      "term": "COLITIS",
      "count": 57
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 56
    },
    {
      "term": "HYPOTENSION",
      "count": 55
    },
    {
      "term": "PAIN",
      "count": 54
    },
    {
      "term": "ANAEMIA",
      "count": 45
    },
    {
      "term": "DIZZINESS",
      "count": 43
    },
    {
      "term": "RASH",
      "count": 41
    },
    {
      "term": "CRYSTAL DEPOSIT INTESTINE",
      "count": 40
    },
    {
      "term": "PNEUMONIA",
      "count": 39
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 38
    },
    {
      "term": "HYPERPHOSPHATAEMIA",
      "count": 38
    },
    {
      "term": "DECREASED APPETITE",
      "count": 37
    },
    {
      "term": "ASTHENIA",
      "count": 34
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 34
    },
    {
      "term": "HAEMATOCHEZIA",
      "count": 34
    },
    {
      "term": "ANXIETY",
      "count": 33
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 33
    },
    {
      "term": "FALL",
      "count": 31
    },
    {
      "term": "HYPERTENSION",
      "count": 31
    },
    {
      "term": "LARGE INTESTINAL ULCER",
      "count": 29
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 28
    },
    {
      "term": "ARTHRALGIA",
      "count": 27
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 27
    },
    {
      "term": "HEADACHE",
      "count": 27
    },
    {
      "term": "MALAISE",
      "count": 27
    },
    {
      "term": "PYREXIA",
      "count": 27
    },
    {
      "term": "DRUG INTERACTION",
      "count": 26
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 25
    },
    {
      "term": "COUGH",
      "count": 25
    },
    {
      "term": "DIALYSIS",
      "count": 25
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 24
    },
    {
      "term": "CHEST PAIN",
      "count": 23
    },
    {
      "term": "EMOTIONAL DISTRESS",
      "count": 23
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 22
    },
    {
      "term": "SEPSIS",
      "count": 22
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 22
    },
    {
      "term": "COLITIS ISCHAEMIC",
      "count": 21
    },
    {
      "term": "RENAL DISORDER",
      "count": 21
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 20
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 20
    },
    {
      "term": "DEPRESSION",
      "count": 20
    },
    {
      "term": "HOSPITALISATION",
      "count": 20
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 20
    },
    {
      "term": "TREATMENT NONCOMPLIANCE",
      "count": 20
    },
    {
      "term": "ANHEDONIA",
      "count": 19
    },
    {
      "term": "BACK PAIN",
      "count": 18
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 18
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 18
    },
    {
      "term": "CARDIAC ARREST",
      "count": 18
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 18
    },
    {
      "term": "LOSS OF CONSCIOUSNESS",
      "count": 18
    },
    {
      "term": "NEPHROGENIC ANAEMIA",
      "count": 18
    },
    {
      "term": "PERITONITIS",
      "count": 18
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 18
    },
    {
      "term": "BLOOD PHOSPHORUS INCREASED",
      "count": 17
    },
    {
      "term": "ECONOMIC PROBLEM",
      "count": 17
    },
    {
      "term": "GASTROINTESTINAL INJURY",
      "count": 17
    },
    {
      "term": "HYPERKALAEMIA",
      "count": 17
    },
    {
      "term": "BLOOD GLUCOSE INCREASED",
      "count": 16
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 16
    },
    {
      "term": "COVID-19",
      "count": 16
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 16
    },
    {
      "term": "INTESTINAL OBSTRUCTION",
      "count": 16
    },
    {
      "term": "PALPITATIONS",
      "count": 16
    },
    {
      "term": "SEIZURE",
      "count": 16
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 15
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 15
    },
    {
      "term": "HYPERVOLAEMIA",
      "count": 15
    },
    {
      "term": "OVERDOSE",
      "count": 15
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 15
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 15
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 15
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 15
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 14
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 14
    },
    {
      "term": "MYOCARDIAL INFARCTION",
      "count": 14
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 14
    },
    {
      "term": "RECTAL ULCER",
      "count": 14
    },
    {
      "term": "SOMNOLENCE",
      "count": 14
    },
    {
      "term": "CHILLS",
      "count": 13
    },
    {
      "term": "CONTUSION",
      "count": 13
    },
    {
      "term": "INFECTION",
      "count": 13
    },
    {
      "term": "LOWER GASTROINTESTINAL HAEMORRHAGE",
      "count": 13
    },
    {
      "term": "RECTAL HAEMORRHAGE",
      "count": 13
    },
    {
      "term": "CALCIPHYLAXIS",
      "count": 12
    },
    {
      "term": "DYSPEPSIA",
      "count": 12
    },
    {
      "term": "DYSPHAGIA",
      "count": 12
    }
  ]
}