{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "NEUTROPENIA",
      "count": 1226
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 843
    },
    {
      "term": "METASTASES TO BONE",
      "count": 613
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 444
    },
    {
      "term": "FATIGUE",
      "count": 428
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 407
    },
    {
      "term": "DEATH",
      "count": 394
    },
    {
      "term": "NAUSEA",
      "count": 371
    },
    {
      "term": "ASTHENIA",
      "count": 321
    },
    {
      "term": "ANAEMIA",
      "count": 312
    },
    {
      "term": "OFF LABEL USE",
      "count": 292
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 288
    },
    {
      "term": "DYSPNOEA",
      "count": 271
    },
    {
      "term": "LEUKOPENIA",
      "count": 269
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 252
    },
    {
      "term": "DIARRHOEA",
      "count": 248
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 242
    },
    {
      "term": "BREAST CANCER",
      "count": 240
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 234
    },
    {
      "term": "PAIN",
      "count": 234
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 219
    },
    {
      "term": "ARTHRALGIA",
      "count": 217
    },
    {
      "term": "VOMITING",
      "count": 213
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 210
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 209
    },
    {
      "term": "PYREXIA",
      "count": 209
    },
    {
      "term": "RASH",
      "count": 198
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 194
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 192
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 186
    },
    {
      "term": "BACK PAIN",
      "count": 176
    },
    {
      "term": "COUGH",
      "count": 172
    },
    {
      "term": "DECREASED APPETITE",
      "count": 172
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 168
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 161
    },
    {
      "term": "PRURITUS",
      "count": 157
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 156
    },
    {
      "term": "HEADACHE",
      "count": 142
    },
    {
      "term": "HYPERTENSION",
      "count": 136
    },
    {
      "term": "PNEUMONIA",
      "count": 136
    },
    {
      "term": "BONE LESION",
      "count": 135
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 132
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 129
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 129
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 128
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 121
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 118
    },
    {
      "term": "DRUG INTERACTION",
      "count": 110
    },
    {
      "term": "BONE PAIN",
      "count": 108
    },
    {
      "term": "LIVER FUNCTION TEST INCREASED",
      "count": 108
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 108
    },
    {
      "term": "CARBOHYDRATE ANTIGEN 15-3 INCREASED",
      "count": 106
    },
    {
      "term": "MALAISE",
      "count": 102
    },
    {
      "term": "ALOPECIA",
      "count": 101
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 101
    },
    {
      "term": "COVID-19",
      "count": 100
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 99
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 99
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 96
    },
    {
      "term": "BREAST MASS",
      "count": 91
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 88
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 87
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 86
    },
    {
      "term": "PULMONARY MASS",
      "count": 85
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 82
    },
    {
      "term": "DIZZINESS",
      "count": 81
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 80
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 80
    },
    {
      "term": "ASCITES",
      "count": 79
    },
    {
      "term": "CONSTIPATION",
      "count": 79
    },
    {
      "term": "HOT FLUSH",
      "count": 78
    },
    {
      "term": "RENAL FAILURE",
      "count": 78
    },
    {
      "term": "HORMONE RECEPTOR POSITIVE HER2 NEGATIVE BREAST CANCER",
      "count": 77
    },
    {
      "term": "LACTIC ACIDOSIS",
      "count": 73
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 71
    },
    {
      "term": "INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION",
      "count": 69
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 69
    },
    {
      "term": "OSTEONECROSIS OF JAW",
      "count": 68
    },
    {
      "term": "CHEST PAIN",
      "count": 67
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 67
    },
    {
      "term": "TUMOUR MARKER INCREASED",
      "count": 67
    },
    {
      "term": "DYSPEPSIA",
      "count": 66
    },
    {
      "term": "HEPATIC LESION",
      "count": 66
    },
    {
      "term": "CARCINOEMBRYONIC ANTIGEN INCREASED",
      "count": 64
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 64
    },
    {
      "term": "DRY SKIN",
      "count": 63
    },
    {
      "term": "INVASIVE DUCTAL BREAST CARCINOMA",
      "count": 63
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 62
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 62
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 62
    },
    {
      "term": "PNEUMONITIS",
      "count": 61
    },
    {
      "term": "MYALGIA",
      "count": 60
    },
    {
      "term": "PIK3CA-ACTIVATED MUTATION",
      "count": 60
    },
    {
      "term": "SKIN HYPOPIGMENTATION",
      "count": 60
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 59
    },
    {
      "term": "METASTASIS",
      "count": 59
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 56
    },
    {
      "term": "BREAST CANCER RECURRENT",
      "count": 56
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 56
    },
    {
      "term": "INSOMNIA",
      "count": 56
    }
  ]
}