{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 1689
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1530
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1064
    },
    {
      "term": "PYREXIA",
      "count": 1013
    },
    {
      "term": "DIARRHOEA",
      "count": 746
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 703
    },
    {
      "term": "NEUTROPENIA",
      "count": 636
    },
    {
      "term": "PNEUMONIA",
      "count": 634
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 621
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 596
    },
    {
      "term": "NAUSEA",
      "count": 546
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 533
    },
    {
      "term": "RASH",
      "count": 519
    },
    {
      "term": "DYSPNOEA",
      "count": 470
    },
    {
      "term": "SEPSIS",
      "count": 470
    },
    {
      "term": "VOMITING",
      "count": 461
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 419
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 389
    },
    {
      "term": "ANAEMIA",
      "count": 374
    },
    {
      "term": "HYPOTENSION",
      "count": 370
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 366
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 366
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 333
    },
    {
      "term": "DRUG INTERACTION",
      "count": 320
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 313
    },
    {
      "term": "PANCYTOPENIA",
      "count": 306
    },
    {
      "term": "FATIGUE",
      "count": 299
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 299
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 297
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 297
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 291
    },
    {
      "term": "CHOLESTASIS",
      "count": 269
    },
    {
      "term": "LEUKOPENIA",
      "count": 264
    },
    {
      "term": "EOSINOPHILIA",
      "count": 262
    },
    {
      "term": "COVID-19",
      "count": 258
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 248
    },
    {
      "term": "PAIN",
      "count": 248
    },
    {
      "term": "MALAISE",
      "count": 244
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 230
    },
    {
      "term": "INFECTION",
      "count": 227
    },
    {
      "term": "PRURITUS",
      "count": 227
    },
    {
      "term": "DEATH",
      "count": 224
    },
    {
      "term": "COUGH",
      "count": 223
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 219
    },
    {
      "term": "ASTHENIA",
      "count": 217
    },
    {
      "term": "RENAL FAILURE",
      "count": 213
    },
    {
      "term": "ERYTHEMA",
      "count": 212
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 206
    },
    {
      "term": "CHILLS",
      "count": 202
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 202
    },
    {
      "term": "HEADACHE",
      "count": 197
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 192
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE COLITIS",
      "count": 190
    },
    {
      "term": "BACK PAIN",
      "count": 185
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 185
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 185
    },
    {
      "term": "ARTHRALGIA",
      "count": 184
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 183
    },
    {
      "term": "HYPERTENSION",
      "count": 181
    },
    {
      "term": "DECREASED APPETITE",
      "count": 175
    },
    {
      "term": "CONSTIPATION",
      "count": 170
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 170
    },
    {
      "term": "AGRANULOCYTOSIS",
      "count": 168
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 168
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 168
    },
    {
      "term": "TACHYCARDIA",
      "count": 165
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 164
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 161
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 160
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 160
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 158
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 158
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 152
    },
    {
      "term": "CELLULITIS",
      "count": 151
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 151
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 148
    },
    {
      "term": "SEIZURE",
      "count": 147
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 145
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 145
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 144
    },
    {
      "term": "CARDIAC ARREST",
      "count": 143
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 138
    },
    {
      "term": "CHEST PAIN",
      "count": 137
    },
    {
      "term": "TOXIC SKIN ERUPTION",
      "count": 136
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 135
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 134
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 132
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 131
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 131
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 126
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 126
    },
    {
      "term": "OVERDOSE",
      "count": 126
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 125
    },
    {
      "term": "ASCITES",
      "count": 123
    },
    {
      "term": "APLASTIC ANAEMIA",
      "count": 122
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 122
    },
    {
      "term": "ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS",
      "count": 121
    },
    {
      "term": "LIVER DISORDER",
      "count": 121
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 118
    },
    {
      "term": "HYPOXIA",
      "count": 118
    }
  ]
}