{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1430
    },
    {
      "term": "OFF LABEL USE",
      "count": 1016
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 939
    },
    {
      "term": "PYREXIA",
      "count": 880
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 479
    },
    {
      "term": "DRUG INTERACTION",
      "count": 477
    },
    {
      "term": "PNEUMONIA",
      "count": 455
    },
    {
      "term": "DIARRHOEA",
      "count": 454
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 441
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 422
    },
    {
      "term": "HYPOTENSION",
      "count": 407
    },
    {
      "term": "SEPSIS",
      "count": 398
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 397
    },
    {
      "term": "DYSPNOEA",
      "count": 396
    },
    {
      "term": "NEUTROPENIA",
      "count": 376
    },
    {
      "term": "RASH",
      "count": 373
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 351
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 342
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 342
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 297
    },
    {
      "term": "PANCYTOPENIA",
      "count": 273
    },
    {
      "term": "VOMITING",
      "count": 269
    },
    {
      "term": "NAUSEA",
      "count": 254
    },
    {
      "term": "ANAEMIA",
      "count": 239
    },
    {
      "term": "RENAL FAILURE",
      "count": 239
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 237
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 231
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 218
    },
    {
      "term": "EOSINOPHILIA",
      "count": 207
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 201
    },
    {
      "term": "DEATH",
      "count": 199
    },
    {
      "term": "PRURITUS",
      "count": 195
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 194
    },
    {
      "term": "CARDIAC ARREST",
      "count": 188
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 182
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 182
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 180
    },
    {
      "term": "MALAISE",
      "count": 178
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 173
    },
    {
      "term": "LEUKOPENIA",
      "count": 170
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 169
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE INFECTION",
      "count": 164
    },
    {
      "term": "TACHYCARDIA",
      "count": 161
    },
    {
      "term": "HYPOXIA",
      "count": 158
    },
    {
      "term": "INFECTION",
      "count": 156
    },
    {
      "term": "CHILLS",
      "count": 155
    },
    {
      "term": "COUGH",
      "count": 155
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 155
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 152
    },
    {
      "term": "FATIGUE",
      "count": 152
    },
    {
      "term": "CHOLESTASIS",
      "count": 150
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 149
    },
    {
      "term": "RENAL TUBULAR NECROSIS",
      "count": 148
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 147
    },
    {
      "term": "ASTHENIA",
      "count": 144
    },
    {
      "term": "ERYTHEMA",
      "count": 143
    },
    {
      "term": "PAIN",
      "count": 142
    },
    {
      "term": "AGRANULOCYTOSIS",
      "count": 141
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 138
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE COLITIS",
      "count": 138
    },
    {
      "term": "COVID-19",
      "count": 138
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 134
    },
    {
      "term": "STEVENS-JOHNSON SYNDROME",
      "count": 131
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 130
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 129
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 128
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 128
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 128
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 127
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 126
    },
    {
      "term": "HYPERTENSION",
      "count": 125
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 123
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 123
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 123
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 123
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 122
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 120
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 118
    },
    {
      "term": "DECREASED APPETITE",
      "count": 118
    },
    {
      "term": "DELIRIUM",
      "count": 118
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 117
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 116
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 115
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 114
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 114
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 113
    },
    {
      "term": "LEUKOCYTOSIS",
      "count": 112
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 111
    },
    {
      "term": "ANAPHYLACTIC REACTION",
      "count": 108
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 107
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 106
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 101
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 101
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 101
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 97
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 97
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 97
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 95
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 94
    },
    {
      "term": "CIRCULATORY COLLAPSE",
      "count": 94
    }
  ]
}