{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 2105
    },
    {
      "term": "ANAEMIA",
      "count": 1454
    },
    {
      "term": "NAUSEA",
      "count": 1205
    },
    {
      "term": "DIARRHOEA",
      "count": 1185
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 1174
    },
    {
      "term": "OFF LABEL USE",
      "count": 1168
    },
    {
      "term": "NEUTROPENIA",
      "count": 1156
    },
    {
      "term": "PANCYTOPENIA",
      "count": 1057
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 1036
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 981
    },
    {
      "term": "VOMITING",
      "count": 917
    },
    {
      "term": "DEATH",
      "count": 916
    },
    {
      "term": "PNEUMONIA",
      "count": 910
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 894
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 874
    },
    {
      "term": "FATIGUE",
      "count": 854
    },
    {
      "term": "PYREXIA",
      "count": 791
    },
    {
      "term": "DYSPNOEA",
      "count": 784
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 765
    },
    {
      "term": "ASTHENIA",
      "count": 742
    },
    {
      "term": "RASH",
      "count": 719
    },
    {
      "term": "DECREASED APPETITE",
      "count": 711
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 637
    },
    {
      "term": "PNEUMONITIS",
      "count": 600
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 574
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 507
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 501
    },
    {
      "term": "LEUKOPENIA",
      "count": 440
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 432
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 431
    },
    {
      "term": "SEPSIS",
      "count": 419
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 399
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 397
    },
    {
      "term": "CONSTIPATION",
      "count": 382
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 372
    },
    {
      "term": "RENAL FAILURE",
      "count": 369
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 368
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 355
    },
    {
      "term": "DEHYDRATION",
      "count": 354
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 344
    },
    {
      "term": "NON-SMALL CELL LUNG CANCER",
      "count": 332
    },
    {
      "term": "COLITIS",
      "count": 329
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 329
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 316
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 315
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 308
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 306
    },
    {
      "term": "HYPERTENSION",
      "count": 304
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 298
    },
    {
      "term": "COUGH",
      "count": 281
    },
    {
      "term": "MALAISE",
      "count": 277
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 270
    },
    {
      "term": "DIZZINESS",
      "count": 266
    },
    {
      "term": "HYPOTENSION",
      "count": 258
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 254
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 252
    },
    {
      "term": "PRURITUS",
      "count": 250
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 248
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 245
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 243
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 238
    },
    {
      "term": "PAIN",
      "count": 238
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 238
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 235
    },
    {
      "term": "STOMATITIS",
      "count": 233
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 232
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 229
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 229
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 227
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 227
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 225
    },
    {
      "term": "HEADACHE",
      "count": 220
    },
    {
      "term": "HEPATITIS",
      "count": 220
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 215
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 214
    },
    {
      "term": "INFECTION",
      "count": 214
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 207
    },
    {
      "term": "HAEMOPTYSIS",
      "count": 206
    },
    {
      "term": "EPISTAXIS",
      "count": 202
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 195
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 194
    },
    {
      "term": "ERYTHEMA",
      "count": 193
    },
    {
      "term": "DRUG INTERACTION",
      "count": 188
    },
    {
      "term": "RENAL TUBULAR NECROSIS",
      "count": 184
    },
    {
      "term": "HYPERTHYROIDISM",
      "count": 181
    },
    {
      "term": "IMMUNE-MEDIATED ENTEROCOLITIS",
      "count": 176
    },
    {
      "term": "CHEST PAIN",
      "count": 174
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 171
    },
    {
      "term": "DYSPHAGIA",
      "count": 170
    },
    {
      "term": "FEBRILE BONE MARROW APLASIA",
      "count": 169
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 166
    },
    {
      "term": "PERICARDIAL EFFUSION",
      "count": 165
    },
    {
      "term": "ARTHRALGIA",
      "count": 163
    },
    {
      "term": "PROTEINURIA",
      "count": 161
    },
    {
      "term": "LUNG ADENOCARCINOMA",
      "count": 160
    },
    {
      "term": "IMMUNE-MEDIATED LUNG DISEASE",
      "count": 159
    },
    {
      "term": "SKIN TOXICITY",
      "count": 157
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 153
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 152
    },
    {
      "term": "OEDEMA",
      "count": 151
    }
  ]
}