{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 526
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 344
    },
    {
      "term": "DIARRHOEA",
      "count": 324
    },
    {
      "term": "DEATH",
      "count": 308
    },
    {
      "term": "FATIGUE",
      "count": 273
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 266
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 265
    },
    {
      "term": "NAUSEA",
      "count": 236
    },
    {
      "term": "OFF LABEL USE",
      "count": 203
    },
    {
      "term": "VOMITING",
      "count": 195
    },
    {
      "term": "HYPERTENSION",
      "count": 194
    },
    {
      "term": "PYREXIA",
      "count": 185
    },
    {
      "term": "DYSPNOEA",
      "count": 184
    },
    {
      "term": "DECREASED APPETITE",
      "count": 176
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 151
    },
    {
      "term": "ANAEMIA",
      "count": 150
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 146
    },
    {
      "term": "ASTHENIA",
      "count": 138
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 120
    },
    {
      "term": "NEUTROPENIA",
      "count": 116
    },
    {
      "term": "DEHYDRATION",
      "count": 114
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 101
    },
    {
      "term": "DRUG INTERACTION",
      "count": 100
    },
    {
      "term": "PNEUMONIA",
      "count": 99
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 93
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 93
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 92
    },
    {
      "term": "MALAISE",
      "count": 88
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 86
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 85
    },
    {
      "term": "THYROID CANCER",
      "count": 85
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 82
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 81
    },
    {
      "term": "HEADACHE",
      "count": 80
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 80
    },
    {
      "term": "PAIN",
      "count": 78
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 78
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 77
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 76
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 74
    },
    {
      "term": "ASCITES",
      "count": 72
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 69
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 68
    },
    {
      "term": "RASH",
      "count": 67
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 64
    },
    {
      "term": "PNEUMOTHORAX",
      "count": 63
    },
    {
      "term": "HAIR COLOUR CHANGES",
      "count": 60
    },
    {
      "term": "RENAL FAILURE",
      "count": 59
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 58
    },
    {
      "term": "PROTEINURIA",
      "count": 58
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 56
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 54
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 54
    },
    {
      "term": "HYPOTENSION",
      "count": 52
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 52
    },
    {
      "term": "SEPSIS",
      "count": 52
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 51
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 50
    },
    {
      "term": "METASTASES TO BONE",
      "count": 49
    },
    {
      "term": "CONSTIPATION",
      "count": 47
    },
    {
      "term": "COUGH",
      "count": 47
    },
    {
      "term": "ARTHRALGIA",
      "count": 46
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 46
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 46
    },
    {
      "term": "DIZZINESS",
      "count": 45
    },
    {
      "term": "RENAL CELL CARCINOMA",
      "count": 44
    },
    {
      "term": "DESMOPLASTIC SMALL ROUND CELL TUMOUR",
      "count": 42
    },
    {
      "term": "INFECTION",
      "count": 42
    },
    {
      "term": "JAUNDICE",
      "count": 42
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 42
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 41
    },
    {
      "term": "BACK PAIN",
      "count": 40
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 40
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 40
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 39
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 38
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 38
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 38
    },
    {
      "term": "STOMATITIS",
      "count": 37
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 36
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 36
    },
    {
      "term": "POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME",
      "count": 36
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 35
    },
    {
      "term": "CARDIAC ARREST",
      "count": 35
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 35
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 34
    },
    {
      "term": "LIVER FUNCTION TEST ABNORMAL",
      "count": 34
    },
    {
      "term": "METASTASES TO PERITONEUM",
      "count": 33
    },
    {
      "term": "OSTEONECROSIS OF JAW",
      "count": 33
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 33
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 32
    },
    {
      "term": "PNEUMONITIS",
      "count": 32
    },
    {
      "term": "CHEST PAIN",
      "count": 31
    },
    {
      "term": "METASTATIC RENAL CELL CARCINOMA",
      "count": 31
    },
    {
      "term": "SYNCOPE",
      "count": 31
    },
    {
      "term": "DYSGEUSIA",
      "count": 30
    },
    {
      "term": "TACHYCARDIA",
      "count": 30
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 30
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 30
    },
    {
      "term": "HAEMOPTYSIS",
      "count": 29
    }
  ]
}