{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG DEPENDENCE",
      "count": 40345
    },
    {
      "term": "OVERDOSE",
      "count": 28495
    },
    {
      "term": "PAIN",
      "count": 26227
    },
    {
      "term": "EMOTIONAL DISTRESS",
      "count": 20702
    },
    {
      "term": "DEATH",
      "count": 16875
    },
    {
      "term": "DEPENDENCE",
      "count": 15383
    },
    {
      "term": "DRUG WITHDRAWAL SYNDROME",
      "count": 14361
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 13653
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 5847
    },
    {
      "term": "ILL-DEFINED DISORDER",
      "count": 5662
    },
    {
      "term": "DRUG ABUSE",
      "count": 5477
    },
    {
      "term": "FATIGUE",
      "count": 5417
    },
    {
      "term": "NAUSEA",
      "count": 4749
    },
    {
      "term": "ANXIETY",
      "count": 4588
    },
    {
      "term": "DEPRESSION",
      "count": 4295
    },
    {
      "term": "DRUG WITHDRAWAL SYNDROME NEONATAL",
      "count": 4217
    },
    {
      "term": "DYSPNOEA",
      "count": 3944
    },
    {
      "term": "ARTHRALGIA",
      "count": 3708
    },
    {
      "term": "RASH",
      "count": 3701
    },
    {
      "term": "OFF LABEL USE",
      "count": 3669
    },
    {
      "term": "HEADACHE",
      "count": 3626
    },
    {
      "term": "VOMITING",
      "count": 3514
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 3450
    },
    {
      "term": "DIARRHOEA",
      "count": 3414
    },
    {
      "term": "PYREXIA",
      "count": 3345
    },
    {
      "term": "JOINT SWELLING",
      "count": 3214
    },
    {
      "term": "PRURITUS",
      "count": 3149
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 3133
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 3028
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 3021
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 3014
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 3007
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 2881
    },
    {
      "term": "INFECTION",
      "count": 2809
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 2784
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 2764
    },
    {
      "term": "INSOMNIA",
      "count": 2662
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 2580
    },
    {
      "term": "RHEUMATOID ARTHRITIS",
      "count": 2580
    },
    {
      "term": "ALOPECIA",
      "count": 2553
    },
    {
      "term": "SINUSITIS",
      "count": 2548
    },
    {
      "term": "SWELLING",
      "count": 2537
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 2497
    },
    {
      "term": "STOMATITIS",
      "count": 2470
    },
    {
      "term": "MALAISE",
      "count": 2425
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 2420
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 2419
    },
    {
      "term": "LOWER RESPIRATORY TRACT INFECTION",
      "count": 2398
    },
    {
      "term": "BLISTER",
      "count": 2392
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 2358
    },
    {
      "term": "DIZZINESS",
      "count": 2346
    },
    {
      "term": "IMPAIRED HEALING",
      "count": 2335
    },
    {
      "term": "FOLLICULITIS",
      "count": 2331
    },
    {
      "term": "IRRITABLE BOWEL SYNDROME",
      "count": 2308
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 2292
    },
    {
      "term": "ARTHROPATHY",
      "count": 2285
    },
    {
      "term": "CONTUSION",
      "count": 2254
    },
    {
      "term": "PNEUMONIA",
      "count": 2252
    },
    {
      "term": "DECREASED APPETITE",
      "count": 2203
    },
    {
      "term": "ASTHENIA",
      "count": 2200
    },
    {
      "term": "CONSTIPATION",
      "count": 2172
    },
    {
      "term": "MUSCLE INJURY",
      "count": 2168
    },
    {
      "term": "SYSTEMIC LUPUS ERYTHEMATOSUS",
      "count": 2157
    },
    {
      "term": "HYPERTENSION",
      "count": 2155
    },
    {
      "term": "SYNOVITIS",
      "count": 2134
    },
    {
      "term": "GLOSSODYNIA",
      "count": 2106
    },
    {
      "term": "HELICOBACTER INFECTION",
      "count": 2092
    },
    {
      "term": "PERICARDITIS",
      "count": 2091
    },
    {
      "term": "PEMPHIGUS",
      "count": 2085
    },
    {
      "term": "HAND DEFORMITY",
      "count": 2061
    },
    {
      "term": "INJURY",
      "count": 2061
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 2023
    },
    {
      "term": "DISCOMFORT",
      "count": 2012
    },
    {
      "term": "DUODENAL ULCER PERFORATION",
      "count": 2010
    },
    {
      "term": "WOUND",
      "count": 1999
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT DECREASED",
      "count": 1958
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 1951
    },
    {
      "term": "DEVELOPMENTAL DELAY",
      "count": 1898
    },
    {
      "term": "CONTRAINDICATED PRODUCT ADMINISTERED",
      "count": 1893
    },
    {
      "term": "ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE",
      "count": 1846
    },
    {
      "term": "ASTHMA",
      "count": 1837
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 1830
    },
    {
      "term": "WITHDRAWAL SYNDROME",
      "count": 1797
    },
    {
      "term": "FALL",
      "count": 1775
    },
    {
      "term": "SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE",
      "count": 1765
    },
    {
      "term": "BACK PAIN",
      "count": 1730
    },
    {
      "term": "URTICARIA",
      "count": 1714
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 1608
    },
    {
      "term": "SOMNOLENCE",
      "count": 1603
    },
    {
      "term": "ROAD TRAFFIC ACCIDENT",
      "count": 1602
    },
    {
      "term": "MENTAL DISORDER",
      "count": 1580
    },
    {
      "term": "DRUG DIVERSION",
      "count": 1565
    },
    {
      "term": "SLEEP DISORDER",
      "count": 1563
    },
    {
      "term": "MUSCULOSKELETAL STIFFNESS",
      "count": 1527
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 1507
    },
    {
      "term": "CHEST PAIN",
      "count": 1496
    },
    {
      "term": "COMPLETED SUICIDE",
      "count": 1422
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 1418
    },
    {
      "term": "FIBROMYALGIA",
      "count": 1382
    },
    {
      "term": "MOBILITY DECREASED",
      "count": 1378
    }
  ]
}