{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DEATH",
      "count": 1601
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 1259
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 831
    },
    {
      "term": "ACQUIRED GENE MUTATION",
      "count": 430
    },
    {
      "term": "DIARRHOEA",
      "count": 404
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 341
    },
    {
      "term": "OFF LABEL USE",
      "count": 322
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 303
    },
    {
      "term": "FATIGUE",
      "count": 293
    },
    {
      "term": "RASH",
      "count": 259
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 238
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 227
    },
    {
      "term": "NAUSEA",
      "count": 224
    },
    {
      "term": "ASTHENIA",
      "count": 214
    },
    {
      "term": "DYSPNOEA",
      "count": 197
    },
    {
      "term": "DECREASED APPETITE",
      "count": 183
    },
    {
      "term": "METASTASES TO MENINGES",
      "count": 166
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 150
    },
    {
      "term": "VOMITING",
      "count": 148
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 128
    },
    {
      "term": "PNEUMONIA",
      "count": 116
    },
    {
      "term": "COUGH",
      "count": 115
    },
    {
      "term": "EGFR GENE MUTATION",
      "count": 115
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 112
    },
    {
      "term": "PYREXIA",
      "count": 112
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 112
    },
    {
      "term": "THROMBOSIS",
      "count": 111
    },
    {
      "term": "PNEUMONITIS",
      "count": 108
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 107
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 107
    },
    {
      "term": "PAIN",
      "count": 104
    },
    {
      "term": "MALIGNANT TRANSFORMATION",
      "count": 98
    },
    {
      "term": "METASTASES TO BONE",
      "count": 98
    },
    {
      "term": "DRY SKIN",
      "count": 96
    },
    {
      "term": "NON-SMALL CELL LUNG CANCER",
      "count": 96
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 94
    },
    {
      "term": "ANAEMIA",
      "count": 93
    },
    {
      "term": "DIZZINESS",
      "count": 93
    },
    {
      "term": "FALL",
      "count": 92
    },
    {
      "term": "HEADACHE",
      "count": 92
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 90
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 90
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 86
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 86
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 81
    },
    {
      "term": "PARONYCHIA",
      "count": 81
    },
    {
      "term": "PANCYTOPENIA",
      "count": 77
    },
    {
      "term": "NEOPLASM MALIGNANT",
      "count": 73
    },
    {
      "term": "PRURITUS",
      "count": 72
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 71
    },
    {
      "term": "CONSTIPATION",
      "count": 70
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 68
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 67
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 65
    },
    {
      "term": "LUNG NEOPLASM MALIGNANT",
      "count": 61
    },
    {
      "term": "STOMATITIS",
      "count": 61
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 60
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 59
    },
    {
      "term": "MALAISE",
      "count": 57
    },
    {
      "term": "HYPOTENSION",
      "count": 56
    },
    {
      "term": "RENAL FAILURE",
      "count": 56
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 56
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 55
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 54
    },
    {
      "term": "SEIZURE",
      "count": 54
    },
    {
      "term": "ALOPECIA",
      "count": 53
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 52
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 52
    },
    {
      "term": "NEUTROPENIA",
      "count": 52
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 51
    },
    {
      "term": "DRUG INTERACTION",
      "count": 50
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 49
    },
    {
      "term": "HYPERTENSION",
      "count": 48
    },
    {
      "term": "ARTHRALGIA",
      "count": 47
    },
    {
      "term": "MYOCARDIAL INFARCTION",
      "count": 45
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 45
    },
    {
      "term": "CARDIAC DISORDER",
      "count": 44
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 44
    },
    {
      "term": "PERICARDIAL EFFUSION",
      "count": 44
    },
    {
      "term": "BACK PAIN",
      "count": 43
    },
    {
      "term": "DEHYDRATION",
      "count": 43
    },
    {
      "term": "DRUG RESISTANCE MUTATION",
      "count": 43
    },
    {
      "term": "OEDEMA",
      "count": 43
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 43
    },
    {
      "term": "CHEST PAIN",
      "count": 42
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 42
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 42
    },
    {
      "term": "MOUTH ULCERATION",
      "count": 41
    },
    {
      "term": "INFECTION",
      "count": 40
    },
    {
      "term": "CARDIOTOXICITY",
      "count": 39
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 38
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 38
    },
    {
      "term": "GENE MUTATION",
      "count": 38
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 38
    },
    {
      "term": "METASTASIS",
      "count": 38
    },
    {
      "term": "DYSPHAGIA",
      "count": 37
    },
    {
      "term": "ONYCHOCLASIS",
      "count": 37
    },
    {
      "term": "SYNCOPE",
      "count": 37
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 37
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 36
    }
  ]
}