{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 5245
    },
    {
      "term": "DEATH",
      "count": 3679
    },
    {
      "term": "DIARRHOEA",
      "count": 2857
    },
    {
      "term": "OFF LABEL USE",
      "count": 2826
    },
    {
      "term": "FATIGUE",
      "count": 2174
    },
    {
      "term": "PYREXIA",
      "count": 2051
    },
    {
      "term": "NAUSEA",
      "count": 1795
    },
    {
      "term": "DYSPNOEA",
      "count": 1705
    },
    {
      "term": "PNEUMONIA",
      "count": 1547
    },
    {
      "term": "PNEUMONITIS",
      "count": 1498
    },
    {
      "term": "DECREASED APPETITE",
      "count": 1437
    },
    {
      "term": "RASH",
      "count": 1370
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1344
    },
    {
      "term": "COLITIS",
      "count": 1334
    },
    {
      "term": "VOMITING",
      "count": 1298
    },
    {
      "term": "ASTHENIA",
      "count": 1292
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1286
    },
    {
      "term": "ANAEMIA",
      "count": 1222
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 1207
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 1141
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 1013
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 925
    },
    {
      "term": "SEPSIS",
      "count": 915
    },
    {
      "term": "PRURITUS",
      "count": 836
    },
    {
      "term": "ARTHRALGIA",
      "count": 770
    },
    {
      "term": "HEADACHE",
      "count": 748
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 738
    },
    {
      "term": "IMMUNE-MEDIATED ENTEROCOLITIS",
      "count": 731
    },
    {
      "term": "COUGH",
      "count": 716
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 699
    },
    {
      "term": "PAIN",
      "count": 695
    },
    {
      "term": "DEHYDRATION",
      "count": 693
    },
    {
      "term": "CONSTIPATION",
      "count": 688
    },
    {
      "term": "HYPOTENSION",
      "count": 686
    },
    {
      "term": "ADRENAL INSUFFICIENCY",
      "count": 678
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 635
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 630
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 625
    },
    {
      "term": "HEPATITIS",
      "count": 611
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 610
    },
    {
      "term": "MALAISE",
      "count": 606
    },
    {
      "term": "HYPERTHYROIDISM",
      "count": 605
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 605
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 586
    },
    {
      "term": "BACK PAIN",
      "count": 585
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 578
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 572
    },
    {
      "term": "MYOCARDITIS",
      "count": 569
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 567
    },
    {
      "term": "NEUTROPENIA",
      "count": 561
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 557
    },
    {
      "term": "HYPERTENSION",
      "count": 537
    },
    {
      "term": "HYPOPHYSITIS",
      "count": 499
    },
    {
      "term": "DIZZINESS",
      "count": 488
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 473
    },
    {
      "term": "RENAL FAILURE",
      "count": 470
    },
    {
      "term": "FALL",
      "count": 462
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 448
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 445
    },
    {
      "term": "IMMUNE-MEDIATED HEPATITIS",
      "count": 437
    },
    {
      "term": "MYOSITIS",
      "count": 422
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 412
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 406
    },
    {
      "term": "DIABETIC KETOACIDOSIS",
      "count": 395
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 390
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 381
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 380
    },
    {
      "term": "PEMPHIGOID",
      "count": 380
    },
    {
      "term": "STOMATITIS",
      "count": 370
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 368
    },
    {
      "term": "DYSPHAGIA",
      "count": 367
    },
    {
      "term": "MYALGIA",
      "count": 364
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 360
    },
    {
      "term": "ARTHRITIS",
      "count": 359
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 354
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 344
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 341
    },
    {
      "term": "AUTOIMMUNE DISORDER",
      "count": 340
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 339
    },
    {
      "term": "TYPE 1 DIABETES MELLITUS",
      "count": 338
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 337
    },
    {
      "term": "CHEST PAIN",
      "count": 331
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 330
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 329
    },
    {
      "term": "SEIZURE",
      "count": 324
    },
    {
      "term": "IMMUNE-MEDIATED LUNG DISEASE",
      "count": 323
    },
    {
      "term": "AUTOIMMUNE HEPATITIS",
      "count": 318
    },
    {
      "term": "CHILLS",
      "count": 318
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 316
    },
    {
      "term": "LIVER DISORDER",
      "count": 311
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 311
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 310
    },
    {
      "term": "IMMUNE-MEDIATED MYOCARDITIS",
      "count": 309
    },
    {
      "term": "INFECTION",
      "count": 308
    },
    {
      "term": "THYROIDITIS",
      "count": 301
    },
    {
      "term": "ASCITES",
      "count": 293
    },
    {
      "term": "PERICARDIAL EFFUSION",
      "count": 293
    },
    {
      "term": "SOMNOLENCE",
      "count": 291
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 284
    },
    {
      "term": "SYNCOPE",
      "count": 280
    }
  ]
}