{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 298
    },
    {
      "term": "OFF LABEL USE",
      "count": 235
    },
    {
      "term": "DEATH",
      "count": 207
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 184
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 163
    },
    {
      "term": "PULMONARY HYPERTENSION",
      "count": 122
    },
    {
      "term": "HYPOTENSION",
      "count": 119
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 115
    },
    {
      "term": "HYPOXIA",
      "count": 106
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 80
    },
    {
      "term": "OXYGEN SATURATION DECREASED",
      "count": 79
    },
    {
      "term": "CARDIAC ARREST",
      "count": 74
    },
    {
      "term": "PULMONARY OEDEMA",
      "count": 62
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 60
    },
    {
      "term": "RIGHT VENTRICULAR FAILURE",
      "count": 60
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 59
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 58
    },
    {
      "term": "PREMATURE BABY",
      "count": 58
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 55
    },
    {
      "term": "PATENT DUCTUS ARTERIOSUS",
      "count": 55
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 54
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 53
    },
    {
      "term": "PULMONARY HAEMORRHAGE",
      "count": 50
    },
    {
      "term": "SEPSIS",
      "count": 48
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 44
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 43
    },
    {
      "term": "PULMONARY ARTERIAL HYPERTENSION",
      "count": 40
    },
    {
      "term": "TACHYCARDIA",
      "count": 39
    },
    {
      "term": "INTENTIONAL OVERDOSE",
      "count": 37
    },
    {
      "term": "NEWBORN PERSISTENT PULMONARY HYPERTENSION",
      "count": 37
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 37
    },
    {
      "term": "EXPOSURE DURING PREGNANCY",
      "count": 36
    },
    {
      "term": "PNEUMOTHORAX",
      "count": 36
    },
    {
      "term": "PREMATURE DELIVERY",
      "count": 36
    },
    {
      "term": "BRADYCARDIA",
      "count": 35
    },
    {
      "term": "INTRAVENTRICULAR HAEMORRHAGE NEONATAL",
      "count": 34
    },
    {
      "term": "PNEUMONIA",
      "count": 34
    },
    {
      "term": "LACTIC ACIDOSIS",
      "count": 33
    },
    {
      "term": "PULMONARY CONGESTION",
      "count": 33
    },
    {
      "term": "VITAMIN B1 DECREASED",
      "count": 33
    },
    {
      "term": "PULMONARY HYPERTENSIVE CRISIS",
      "count": 32
    },
    {
      "term": "HEART RATE INCREASED",
      "count": 31
    },
    {
      "term": "BLOOD LACTIC ACID DECREASED",
      "count": 30
    },
    {
      "term": "ELECTROCARDIOGRAM ABNORMAL",
      "count": 30
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 30
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 29
    },
    {
      "term": "CARDIAC OUTPUT INCREASED",
      "count": 29
    },
    {
      "term": "HYPERLACTACIDAEMIA",
      "count": 29
    },
    {
      "term": "HYPOPHAGIA",
      "count": 29
    },
    {
      "term": "CARDIOGENIC SHOCK",
      "count": 27
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 26
    },
    {
      "term": "DYSPNOEA",
      "count": 26
    },
    {
      "term": "NEONATAL RESPIRATORY DISTRESS SYNDROME",
      "count": 26
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 26
    },
    {
      "term": "BRONCHOPULMONARY DYSPLASIA",
      "count": 25
    },
    {
      "term": "RENAL FAILURE",
      "count": 25
    },
    {
      "term": "NECROTISING COLITIS",
      "count": 23
    },
    {
      "term": "PYREXIA",
      "count": 23
    },
    {
      "term": "ATELECTASIS",
      "count": 22
    },
    {
      "term": "CEREBRAL HAEMORRHAGE",
      "count": 22
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 22
    },
    {
      "term": "HAEMODYNAMIC INSTABILITY",
      "count": 21
    },
    {
      "term": "NEONATAL DISORDER",
      "count": 21
    },
    {
      "term": "NEONATAL HYPOTENSION",
      "count": 21
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 21
    },
    {
      "term": "ACIDOSIS",
      "count": 20
    },
    {
      "term": "BLOOD LACTIC ACID INCREASED",
      "count": 20
    },
    {
      "term": "PULMONARY ALVEOLAR HAEMORRHAGE",
      "count": 20
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 20
    },
    {
      "term": "SHOCK",
      "count": 20
    },
    {
      "term": "COAGULOPATHY",
      "count": 19
    },
    {
      "term": "INTRAVENTRICULAR HAEMORRHAGE",
      "count": 19
    },
    {
      "term": "NO ADVERSE EVENT",
      "count": 19
    },
    {
      "term": "ANAEMIA",
      "count": 18
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 18
    },
    {
      "term": "HAEMORRHAGE",
      "count": 18
    },
    {
      "term": "INFECTION",
      "count": 18
    },
    {
      "term": "LOW BIRTH WEIGHT BABY",
      "count": 18
    },
    {
      "term": "PULMONARY ARTERIAL PRESSURE INCREASED",
      "count": 18
    },
    {
      "term": "PULMONARY VENO-OCCLUSIVE DISEASE",
      "count": 18
    },
    {
      "term": "BRADYCARDIA NEONATAL",
      "count": 17
    },
    {
      "term": "CARDIO-RESPIRATORY ARREST",
      "count": 17
    },
    {
      "term": "LOCAL ANAESTHETIC SYSTEMIC TOXICITY",
      "count": 17
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 16
    },
    {
      "term": "HYPERTROPHIC CARDIOMYOPATHY",
      "count": 16
    },
    {
      "term": "INTESTINAL PERFORATION",
      "count": 16
    },
    {
      "term": "PALLOR",
      "count": 16
    },
    {
      "term": "SYNCOPE",
      "count": 16
    },
    {
      "term": "BLOOD UREA INCREASED",
      "count": 15
    },
    {
      "term": "DIARRHOEA",
      "count": 15
    },
    {
      "term": "HAEMOPTYSIS",
      "count": 15
    },
    {
      "term": "NAUSEA",
      "count": 15
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 15
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 15
    },
    {
      "term": "RETINOPATHY OF PREMATURITY",
      "count": 15
    },
    {
      "term": "VITAMIN B1 INCREASED",
      "count": 15
    },
    {
      "term": "VOMITING",
      "count": 15
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 14
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 14
    },
    {
      "term": "CIRCULATORY COLLAPSE",
      "count": 14
    }
  ]
}