{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 15975
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 9957
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 6864
    },
    {
      "term": "DIARRHOEA",
      "count": 5095
    },
    {
      "term": "PYREXIA",
      "count": 4512
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 4401
    },
    {
      "term": "PNEUMONIA",
      "count": 4213
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 3740
    },
    {
      "term": "TRANSPLANT REJECTION",
      "count": 3569
    },
    {
      "term": "INFECTION",
      "count": 3306
    },
    {
      "term": "FATIGUE",
      "count": 3249
    },
    {
      "term": "NAUSEA",
      "count": 3186
    },
    {
      "term": "COVID-19",
      "count": 3046
    },
    {
      "term": "VOMITING",
      "count": 3010
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 2965
    },
    {
      "term": "DYSPNOEA",
      "count": 2921
    },
    {
      "term": "HEADACHE",
      "count": 2846
    },
    {
      "term": "SEPSIS",
      "count": 2810
    },
    {
      "term": "HYPERTENSION",
      "count": 2760
    },
    {
      "term": "DRUG INTERACTION",
      "count": 2654
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 2625
    },
    {
      "term": "RASH",
      "count": 2471
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 2307
    },
    {
      "term": "ARTHRALGIA",
      "count": 2235
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 2215
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 2139
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 2123
    },
    {
      "term": "DEATH",
      "count": 2106
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 2065
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 2061
    },
    {
      "term": "PAIN",
      "count": 2057
    },
    {
      "term": "POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER",
      "count": 2046
    },
    {
      "term": "ASTHENIA",
      "count": 2040
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 2026
    },
    {
      "term": "MALAISE",
      "count": 2014
    },
    {
      "term": "NEUTROPENIA",
      "count": 2005
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 1990
    },
    {
      "term": "ANAEMIA",
      "count": 1937
    },
    {
      "term": "DECREASED APPETITE",
      "count": 1932
    },
    {
      "term": "ALOPECIA",
      "count": 1927
    },
    {
      "term": "LEUKOPENIA",
      "count": 1907
    },
    {
      "term": "SYSTEMIC LUPUS ERYTHEMATOSUS",
      "count": 1902
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 1901
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 1890
    },
    {
      "term": "RHEUMATOID ARTHRITIS",
      "count": 1849
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 1840
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 1823
    },
    {
      "term": "PRURITUS",
      "count": 1817
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 1779
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 1749
    },
    {
      "term": "JOINT SWELLING",
      "count": 1740
    },
    {
      "term": "SINUSITIS",
      "count": 1739
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 1737
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 1652
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 1648
    },
    {
      "term": "DIZZINESS",
      "count": 1645
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 1642
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 1640
    },
    {
      "term": "COUGH",
      "count": 1599
    },
    {
      "term": "PSORIATIC ARTHROPATHY",
      "count": 1574
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 1547
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 1543
    },
    {
      "term": "KIDNEY TRANSPLANT REJECTION",
      "count": 1525
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 1515
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 1499
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 1497
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 1492
    },
    {
      "term": "EPSTEIN-BARR VIRUS INFECTION",
      "count": 1482
    },
    {
      "term": "PANCYTOPENIA",
      "count": 1474
    },
    {
      "term": "STOMATITIS",
      "count": 1455
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 1448
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 1440
    },
    {
      "term": "SWELLING",
      "count": 1436
    },
    {
      "term": "TYPE 2 DIABETES MELLITUS",
      "count": 1431
    },
    {
      "term": "SCIATICA",
      "count": 1427
    },
    {
      "term": "SYNOVITIS",
      "count": 1426
    },
    {
      "term": "MOBILITY DECREASED",
      "count": 1420
    },
    {
      "term": "IMPAIRED HEALING",
      "count": 1419
    },
    {
      "term": "OEDEMA",
      "count": 1418
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 1406
    },
    {
      "term": "POLYOMAVIRUS-ASSOCIATED NEPHROPATHY",
      "count": 1400
    },
    {
      "term": "FIBROMYALGIA",
      "count": 1398
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE",
      "count": 1397
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 1390
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 1389
    },
    {
      "term": "CHEST PAIN",
      "count": 1366
    },
    {
      "term": "CYTOMEGALOVIRUS VIRAEMIA",
      "count": 1360
    },
    {
      "term": "WOUND",
      "count": 1345
    },
    {
      "term": "DUODENAL ULCER PERFORATION",
      "count": 1339
    },
    {
      "term": "HAND DEFORMITY",
      "count": 1339
    },
    {
      "term": "URTICARIA",
      "count": 1339
    },
    {
      "term": "INSOMNIA",
      "count": 1335
    },
    {
      "term": "GLOSSODYNIA",
      "count": 1333
    },
    {
      "term": "HELICOBACTER INFECTION",
      "count": 1332
    },
    {
      "term": "RENAL FAILURE",
      "count": 1329
    },
    {
      "term": "BK VIRUS INFECTION",
      "count": 1326
    },
    {
      "term": "PEMPHIGUS",
      "count": 1321
    },
    {
      "term": "FOLLICULITIS",
      "count": 1306
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 1305
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 1304
    }
  ]
}