{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 898
    },
    {
      "term": "NEUTROPENIA",
      "count": 494
    },
    {
      "term": "OFF LABEL USE",
      "count": 490
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 467
    },
    {
      "term": "PYREXIA",
      "count": 389
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 360
    },
    {
      "term": "SEPSIS",
      "count": 348
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 317
    },
    {
      "term": "PNEUMONIA",
      "count": 275
    },
    {
      "term": "PANCYTOPENIA",
      "count": 251
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 250
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 234
    },
    {
      "term": "DEATH",
      "count": 224
    },
    {
      "term": "INFECTION",
      "count": 224
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 210
    },
    {
      "term": "ANAEMIA",
      "count": 204
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 204
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 178
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 153
    },
    {
      "term": "DIARRHOEA",
      "count": 152
    },
    {
      "term": "NAUSEA",
      "count": 151
    },
    {
      "term": "HYPOTENSION",
      "count": 147
    },
    {
      "term": "FATIGUE",
      "count": 140
    },
    {
      "term": "VOMITING",
      "count": 132
    },
    {
      "term": "DYSPNOEA",
      "count": 130
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 130
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 130
    },
    {
      "term": "LEUKOPENIA",
      "count": 127
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 125
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 125
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 123
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 120
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 112
    },
    {
      "term": "HEADACHE",
      "count": 106
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 102
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 101
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 98
    },
    {
      "term": "SECOND PRIMARY MALIGNANCY",
      "count": 98
    },
    {
      "term": "ACUTE PROMYELOCYTIC LEUKAEMIA",
      "count": 97
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 91
    },
    {
      "term": "COLITIS",
      "count": 88
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 86
    },
    {
      "term": "DRUG INTERACTION",
      "count": 85
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 84
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 83
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 81
    },
    {
      "term": "MALAISE",
      "count": 81
    },
    {
      "term": "TACHYCARDIA",
      "count": 81
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 80
    },
    {
      "term": "RENAL FAILURE",
      "count": 80
    },
    {
      "term": "ASTHENIA",
      "count": 77
    },
    {
      "term": "VENOOCCLUSIVE LIVER DISEASE",
      "count": 77
    },
    {
      "term": "BACTERAEMIA",
      "count": 76
    },
    {
      "term": "LEUKAEMIA RECURRENT",
      "count": 76
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 75
    },
    {
      "term": "PAIN",
      "count": 75
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 75
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 74
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 73
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 72
    },
    {
      "term": "ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT",
      "count": 71
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 70
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 70
    },
    {
      "term": "STOMATITIS",
      "count": 70
    },
    {
      "term": "ALOPECIA",
      "count": 69
    },
    {
      "term": "CHILLS",
      "count": 69
    },
    {
      "term": "CARDIOMYOPATHY",
      "count": 68
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 68
    },
    {
      "term": "CARDIOTOXICITY",
      "count": 67
    },
    {
      "term": "RASH",
      "count": 66
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 64
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 63
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 63
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 61
    },
    {
      "term": "FEBRILE BONE MARROW APLASIA",
      "count": 60
    },
    {
      "term": "HYPOXIA",
      "count": 60
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA RECURRENT",
      "count": 59
    },
    {
      "term": "CEREBRAL HAEMORRHAGE",
      "count": 59
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 58
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 58
    },
    {
      "term": "OSTEONECROSIS",
      "count": 58
    },
    {
      "term": "PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY",
      "count": 58
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 57
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 56
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 56
    },
    {
      "term": "HERPES ZOSTER",
      "count": 56
    },
    {
      "term": "CYTOPENIA",
      "count": 54
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 53
    },
    {
      "term": "COUGH",
      "count": 53
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 53
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 53
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 52
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 52
    },
    {
      "term": "DIZZINESS",
      "count": 51
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 51
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 50
    },
    {
      "term": "BACK PAIN",
      "count": 49
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 49
    },
    {
      "term": "HAEMORRHAGE",
      "count": 49
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 49
    }
  ]
}