{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 471
    },
    {
      "term": "DIARRHOEA",
      "count": 234
    },
    {
      "term": "NAUSEA",
      "count": 193
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 166
    },
    {
      "term": "NEUTROPENIA",
      "count": 162
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 156
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 142
    },
    {
      "term": "VOMITING",
      "count": 131
    },
    {
      "term": "PANCYTOPENIA",
      "count": 120
    },
    {
      "term": "FATIGUE",
      "count": 119
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 103
    },
    {
      "term": "DEATH",
      "count": 102
    },
    {
      "term": "PYREXIA",
      "count": 102
    },
    {
      "term": "LEUKOPENIA",
      "count": 93
    },
    {
      "term": "ANAEMIA",
      "count": 90
    },
    {
      "term": "DYSPNOEA",
      "count": 86
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 80
    },
    {
      "term": "PAIN",
      "count": 79
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 75
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 71
    },
    {
      "term": "SEPSIS",
      "count": 70
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 69
    },
    {
      "term": "RASH",
      "count": 69
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 62
    },
    {
      "term": "ASTHENIA",
      "count": 61
    },
    {
      "term": "DYSURIA",
      "count": 61
    },
    {
      "term": "DECREASED APPETITE",
      "count": 58
    },
    {
      "term": "DEHYDRATION",
      "count": 56
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 56
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 55
    },
    {
      "term": "RENAL FAILURE",
      "count": 53
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 50
    },
    {
      "term": "PULMONARY VENO-OCCLUSIVE DISEASE",
      "count": 49
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 45
    },
    {
      "term": "HYPERTENSION",
      "count": 44
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 44
    },
    {
      "term": "RADIATION SKIN INJURY",
      "count": 44
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 43
    },
    {
      "term": "VISUAL ACUITY REDUCED",
      "count": 43
    },
    {
      "term": "ERYTHEMA",
      "count": 40
    },
    {
      "term": "HYPOTENSION",
      "count": 40
    },
    {
      "term": "INFECTION",
      "count": 39
    },
    {
      "term": "POLLAKIURIA",
      "count": 39
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 39
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 39
    },
    {
      "term": "STOMATITIS",
      "count": 38
    },
    {
      "term": "BLADDER PERFORATION",
      "count": 37
    },
    {
      "term": "HAEMOLYTIC URAEMIC SYNDROME",
      "count": 37
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 37
    },
    {
      "term": "PNEUMONIA",
      "count": 37
    },
    {
      "term": "INCORRECT ROUTE OF DRUG ADMINISTRATION",
      "count": 36
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 35
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 35
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 35
    },
    {
      "term": "CONSTIPATION",
      "count": 35
    },
    {
      "term": "ENDOPHTHALMITIS",
      "count": 32
    },
    {
      "term": "PRURITUS",
      "count": 32
    },
    {
      "term": "HYPOTONY OF EYE",
      "count": 31
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 31
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 31
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 31
    },
    {
      "term": "ALOPECIA",
      "count": 30
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 30
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 30
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 30
    },
    {
      "term": "GASTROINTESTINAL TOXICITY",
      "count": 29
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 29
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 29
    },
    {
      "term": "COUGH",
      "count": 28
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 28
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 28
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 28
    },
    {
      "term": "ASCITES",
      "count": 27
    },
    {
      "term": "CONJUNCTIVAL FILTERING BLEB LEAK",
      "count": 27
    },
    {
      "term": "SCLERAL THINNING",
      "count": 27
    },
    {
      "term": "ARTHRALGIA",
      "count": 26
    },
    {
      "term": "CHEST PAIN",
      "count": 26
    },
    {
      "term": "DERMATITIS",
      "count": 26
    },
    {
      "term": "CHILLS",
      "count": 25
    },
    {
      "term": "CYSTITIS",
      "count": 25
    },
    {
      "term": "HAEMATURIA",
      "count": 25
    },
    {
      "term": "MALAISE",
      "count": 25
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 25
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 24
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 24
    },
    {
      "term": "HEADACHE",
      "count": 24
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 24
    },
    {
      "term": "BLEBITIS",
      "count": 23
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 23
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 23
    },
    {
      "term": "DYSPHAGIA",
      "count": 22
    },
    {
      "term": "ILEUS",
      "count": 22
    },
    {
      "term": "LIVER ABSCESS",
      "count": 22
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 22
    },
    {
      "term": "SCLEROMALACIA",
      "count": 22
    },
    {
      "term": "BACK PAIN",
      "count": 21
    },
    {
      "term": "BLADDER CANCER RECURRENT",
      "count": 21
    },
    {
      "term": "GASTRIC PERFORATION",
      "count": 21
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 21
    },
    {
      "term": "POST PROCEDURAL COMPLICATION",
      "count": 21
    }
  ]
}