{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1084
    },
    {
      "term": "OFF LABEL USE",
      "count": 646
    },
    {
      "term": "PYREXIA",
      "count": 526
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 445
    },
    {
      "term": "PNEUMONIA",
      "count": 342
    },
    {
      "term": "SEPSIS",
      "count": 325
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 308
    },
    {
      "term": "DIARRHOEA",
      "count": 283
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 279
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 261
    },
    {
      "term": "NEUTROPENIA",
      "count": 253
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 246
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 245
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 242
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 202
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 183
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 181
    },
    {
      "term": "ANAEMIA",
      "count": 181
    },
    {
      "term": "DEATH",
      "count": 180
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 176
    },
    {
      "term": "RENAL FAILURE",
      "count": 172
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 164
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 162
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 161
    },
    {
      "term": "NAUSEA",
      "count": 161
    },
    {
      "term": "INFECTION",
      "count": 159
    },
    {
      "term": "HYPOTENSION",
      "count": 153
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 153
    },
    {
      "term": "DRUG INTERACTION",
      "count": 151
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 148
    },
    {
      "term": "DYSPNOEA",
      "count": 142
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 142
    },
    {
      "term": "VOMITING",
      "count": 139
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 138
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 137
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 136
    },
    {
      "term": "PANCYTOPENIA",
      "count": 136
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 131
    },
    {
      "term": "RASH",
      "count": 130
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 121
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 116
    },
    {
      "term": "MULTI-ORGAN FAILURE",
      "count": 116
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 114
    },
    {
      "term": "CARDIAC ARREST",
      "count": 111
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 110
    },
    {
      "term": "HYPERTENSION",
      "count": 107
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE IN SKIN",
      "count": 106
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 105
    },
    {
      "term": "HYPOXIA",
      "count": 105
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 101
    },
    {
      "term": "GRAFT VERSUS HOST DISEASE",
      "count": 100
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE",
      "count": 99
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 99
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 96
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 95
    },
    {
      "term": "LIVER DISORDER",
      "count": 94
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 92
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 91
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 91
    },
    {
      "term": "MUCORMYCOSIS",
      "count": 90
    },
    {
      "term": "PNEUMONIA FUNGAL",
      "count": 89
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 88
    },
    {
      "term": "SYSTEMIC CANDIDA",
      "count": 88
    },
    {
      "term": "LEUKOPENIA",
      "count": 87
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 83
    },
    {
      "term": "FUNGAEMIA",
      "count": 81
    },
    {
      "term": "ENTEROCOCCAL INFECTION",
      "count": 80
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 79
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 79
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 77
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 77
    },
    {
      "term": "TACHYCARDIA",
      "count": 76
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 74
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 74
    },
    {
      "term": "VENOOCCLUSIVE LIVER DISEASE",
      "count": 74
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 72
    },
    {
      "term": "HUMAN HERPESVIRUS 6 INFECTION",
      "count": 72
    },
    {
      "term": "STOMATITIS",
      "count": 69
    },
    {
      "term": "BACTERAEMIA",
      "count": 67
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 67
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 65
    },
    {
      "term": "HEADACHE",
      "count": 65
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 65
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 64
    },
    {
      "term": "CYTOMEGALOVIRUS TEST POSITIVE",
      "count": 64
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 64
    },
    {
      "term": "SHOCK",
      "count": 63
    },
    {
      "term": "CEREBRAL HAEMORRHAGE",
      "count": 62
    },
    {
      "term": "ENCEPHALITIS VIRAL",
      "count": 62
    },
    {
      "term": "PAIN",
      "count": 62
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 62
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 61
    },
    {
      "term": "CYTOMEGALOVIRUS VIRAEMIA",
      "count": 60
    },
    {
      "term": "ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE",
      "count": 59
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 59
    },
    {
      "term": "FATIGUE",
      "count": 59
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 59
    },
    {
      "term": "HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS",
      "count": 58
    },
    {
      "term": "HYPERBILIRUBINAEMIA",
      "count": 58
    },
    {
      "term": "HYPOALBUMINAEMIA",
      "count": 58
    }
  ]
}