{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DYSPNOEA",
      "count": 1240
    },
    {
      "term": "DEATH",
      "count": 884
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 810
    },
    {
      "term": "NAUSEA",
      "count": 765
    },
    {
      "term": "RENAL FAILURE",
      "count": 727
    },
    {
      "term": "CARDIAC FAILURE CONGESTIVE",
      "count": 685
    },
    {
      "term": "FATIGUE",
      "count": 671
    },
    {
      "term": "DIARRHOEA",
      "count": 652
    },
    {
      "term": "DIZZINESS",
      "count": 626
    },
    {
      "term": "HYPOTENSION",
      "count": 601
    },
    {
      "term": "ASTHENIA",
      "count": 593
    },
    {
      "term": "CHRONIC KIDNEY DISEASE",
      "count": 590
    },
    {
      "term": "HEADACHE",
      "count": 565
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 536
    },
    {
      "term": "FALL",
      "count": 524
    },
    {
      "term": "FLUID RETENTION",
      "count": 502
    },
    {
      "term": "PNEUMONIA",
      "count": 495
    },
    {
      "term": "PAIN",
      "count": 432
    },
    {
      "term": "VOMITING",
      "count": 398
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 394
    },
    {
      "term": "ANAEMIA",
      "count": 387
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 375
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 371
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 356
    },
    {
      "term": "DEHYDRATION",
      "count": 354
    },
    {
      "term": "MALAISE",
      "count": 353
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 350
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 342
    },
    {
      "term": "COUGH",
      "count": 339
    },
    {
      "term": "CHEST PAIN",
      "count": 333
    },
    {
      "term": "OEDEMA",
      "count": 330
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 329
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 327
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 323
    },
    {
      "term": "END STAGE RENAL DISEASE",
      "count": 315
    },
    {
      "term": "OFF LABEL USE",
      "count": 313
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 308
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 294
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 270
    },
    {
      "term": "ARTHRALGIA",
      "count": 253
    },
    {
      "term": "DECREASED APPETITE",
      "count": 249
    },
    {
      "term": "PYREXIA",
      "count": 241
    },
    {
      "term": "SYNCOPE",
      "count": 239
    },
    {
      "term": "FLUID OVERLOAD",
      "count": 237
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 232
    },
    {
      "term": "BACK PAIN",
      "count": 231
    },
    {
      "term": "BLOOD GLUCOSE INCREASED",
      "count": 226
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 223
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 222
    },
    {
      "term": "CONSTIPATION",
      "count": 221
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 217
    },
    {
      "term": "PULMONARY HYPERTENSION",
      "count": 216
    },
    {
      "term": "ANXIETY",
      "count": 215
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 205
    },
    {
      "term": "SEPSIS",
      "count": 204
    },
    {
      "term": "PULMONARY ARTERIAL HYPERTENSION",
      "count": 201
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 198
    },
    {
      "term": "BLOOD POTASSIUM DECREASED",
      "count": 196
    },
    {
      "term": "HOSPITALISATION",
      "count": 195
    },
    {
      "term": "PRURITUS",
      "count": 194
    },
    {
      "term": "DYSPNOEA EXERTIONAL",
      "count": 189
    },
    {
      "term": "CELLULITIS",
      "count": 187
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 185
    },
    {
      "term": "DRUG INTERACTION",
      "count": 184
    },
    {
      "term": "HYPERTENSION",
      "count": 184
    },
    {
      "term": "CARDIAC ARREST",
      "count": 183
    },
    {
      "term": "EPISTAXIS",
      "count": 182
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 179
    },
    {
      "term": "RASH",
      "count": 178
    },
    {
      "term": "PULMONARY OEDEMA",
      "count": 176
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 175
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 174
    },
    {
      "term": "LOSS OF CONSCIOUSNESS",
      "count": 174
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 173
    },
    {
      "term": "CHRONIC OBSTRUCTIVE PULMONARY DISEASE",
      "count": 172
    },
    {
      "term": "OXYGEN SATURATION DECREASED",
      "count": 170
    },
    {
      "term": "HYPERKALAEMIA",
      "count": 168
    },
    {
      "term": "MYOCARDIAL INFARCTION",
      "count": 163
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 163
    },
    {
      "term": "MUSCLE SPASMS",
      "count": 161
    },
    {
      "term": "NEPHROGENIC ANAEMIA",
      "count": 153
    },
    {
      "term": "CHEST DISCOMFORT",
      "count": 150
    },
    {
      "term": "INSOMNIA",
      "count": 150
    },
    {
      "term": "HYPOXIA",
      "count": 149
    },
    {
      "term": "RIGHT VENTRICULAR FAILURE",
      "count": 148
    },
    {
      "term": "SOMNOLENCE",
      "count": 147
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 145
    },
    {
      "term": "DEPRESSION",
      "count": 145
    },
    {
      "term": "RENAL INJURY",
      "count": 143
    },
    {
      "term": "PALPITATIONS",
      "count": 142
    },
    {
      "term": "CARDIAC DISORDER",
      "count": 140
    },
    {
      "term": "SWELLING",
      "count": 139
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 134
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 131
    },
    {
      "term": "RENAL DISORDER",
      "count": 131
    },
    {
      "term": "MYALGIA",
      "count": 130
    },
    {
      "term": "TREMOR",
      "count": 130
    },
    {
      "term": "PAIN IN JAW",
      "count": 126
    },
    {
      "term": "ERYTHEMA",
      "count": 123
    },
    {
      "term": "NASOPHARYNGITIS",
      "count": 123
    }
  ]
}