{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "SEROTONIN SYNDROME",
      "count": 513
    },
    {
      "term": "DRUG INTERACTION",
      "count": 398
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 297
    },
    {
      "term": "HYPOTENSION",
      "count": 209
    },
    {
      "term": "OFF LABEL USE",
      "count": 191
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 140
    },
    {
      "term": "OVERDOSE",
      "count": 100
    },
    {
      "term": "INTENTIONAL OVERDOSE",
      "count": 98
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 92
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 81
    },
    {
      "term": "TOXIC ENCEPHALOPATHY",
      "count": 80
    },
    {
      "term": "AGITATION",
      "count": 79
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 76
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 70
    },
    {
      "term": "VASOPLEGIA SYNDROME",
      "count": 70
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 69
    },
    {
      "term": "BLOOD POTASSIUM INCREASED",
      "count": 65
    },
    {
      "term": "CARDIAC ARREST",
      "count": 64
    },
    {
      "term": "TROPONIN INCREASED",
      "count": 63
    },
    {
      "term": "BLOOD LACTATE DEHYDROGENASE INCREASED",
      "count": 62
    },
    {
      "term": "MYOGLOBIN URINE PRESENT",
      "count": 62
    },
    {
      "term": "AMYLASE INCREASED",
      "count": 61
    },
    {
      "term": "BRADYCARDIA",
      "count": 61
    },
    {
      "term": "LACTIC ACIDOSIS",
      "count": 61
    },
    {
      "term": "SHOCK",
      "count": 60
    },
    {
      "term": "COMA",
      "count": 59
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 54
    },
    {
      "term": "METHAEMOGLOBINAEMIA",
      "count": 54
    },
    {
      "term": "MYDRIASIS",
      "count": 54
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 52
    },
    {
      "term": "CARDIOGENIC SHOCK",
      "count": 51
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 48
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 43
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 43
    },
    {
      "term": "DEPRESSED LEVEL OF CONSCIOUSNESS",
      "count": 42
    },
    {
      "term": "CLONUS",
      "count": 41
    },
    {
      "term": "HYPERREFLEXIA",
      "count": 41
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 41
    },
    {
      "term": "TACHYCARDIA",
      "count": 41
    },
    {
      "term": "DISTRIBUTIVE SHOCK",
      "count": 39
    },
    {
      "term": "MUSCLE RIGIDITY",
      "count": 35
    },
    {
      "term": "NYSTAGMUS",
      "count": 35
    },
    {
      "term": "CHROMATURIA",
      "count": 32
    },
    {
      "term": "HYPERHIDROSIS",
      "count": 32
    },
    {
      "term": "HYPERKALAEMIA",
      "count": 31
    },
    {
      "term": "HYPERTENSION",
      "count": 31
    },
    {
      "term": "MENTAL STATUS CHANGES",
      "count": 30
    },
    {
      "term": "POST PROCEDURAL COMPLICATION",
      "count": 29
    },
    {
      "term": "SUICIDE ATTEMPT",
      "count": 29
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 28
    },
    {
      "term": "HAEMOLYTIC ANAEMIA",
      "count": 28
    },
    {
      "term": "SOMNOLENCE",
      "count": 28
    },
    {
      "term": "DYSKINESIA",
      "count": 27
    },
    {
      "term": "ANAPHYLACTIC REACTION",
      "count": 26
    },
    {
      "term": "PYREXIA",
      "count": 26
    },
    {
      "term": "COMA SCALE ABNORMAL",
      "count": 25
    },
    {
      "term": "ANXIETY",
      "count": 24
    },
    {
      "term": "APHASIA",
      "count": 24
    },
    {
      "term": "DELIRIUM",
      "count": 24
    },
    {
      "term": "DISORIENTATION",
      "count": 24
    },
    {
      "term": "SEIZURE",
      "count": 24
    },
    {
      "term": "RENAL FAILURE",
      "count": 23
    },
    {
      "term": "HYPERTHERMIA",
      "count": 22
    },
    {
      "term": "HYPOXIA",
      "count": 22
    },
    {
      "term": "ILEUS",
      "count": 22
    },
    {
      "term": "TREMOR",
      "count": 22
    },
    {
      "term": "CIRCULATORY COLLAPSE",
      "count": 21
    },
    {
      "term": "PULSE ABSENT",
      "count": 21
    },
    {
      "term": "SKIN DISCOLOURATION",
      "count": 21
    },
    {
      "term": "VOMITING",
      "count": 21
    },
    {
      "term": "COMPARTMENT SYNDROME",
      "count": 20
    },
    {
      "term": "DRUG LEVEL BELOW THERAPEUTIC",
      "count": 20
    },
    {
      "term": "HAEMODYNAMIC INSTABILITY",
      "count": 20
    },
    {
      "term": "MYOCLONUS",
      "count": 20
    },
    {
      "term": "NAUSEA",
      "count": 20
    },
    {
      "term": "PNEUMONIA",
      "count": 20
    },
    {
      "term": "UNRESPONSIVE TO STIMULI",
      "count": 20
    },
    {
      "term": "FATIGUE",
      "count": 19
    },
    {
      "term": "ANAPHYLACTIC SHOCK",
      "count": 18
    },
    {
      "term": "HYPERTONIA",
      "count": 18
    },
    {
      "term": "PULMONARY OEDEMA",
      "count": 18
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 18
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 18
    },
    {
      "term": "WHITE BLOOD CELL COUNT INCREASED",
      "count": 18
    },
    {
      "term": "ACIDOSIS",
      "count": 17
    },
    {
      "term": "GENERALISED TONIC-CLONIC SEIZURE",
      "count": 17
    },
    {
      "term": "LINEAR IGA DISEASE",
      "count": 17
    },
    {
      "term": "OXYGEN SATURATION DECREASED",
      "count": 17
    },
    {
      "term": "RESPIRATORY DEPRESSION",
      "count": 17
    },
    {
      "term": "RESTLESSNESS",
      "count": 17
    },
    {
      "term": "SPEECH DISORDER",
      "count": 17
    },
    {
      "term": "DELAYED RECOVERY FROM ANAESTHESIA",
      "count": 15
    },
    {
      "term": "DYSPNOEA",
      "count": 15
    },
    {
      "term": "ELECTROCARDIOGRAM QRS COMPLEX PROLONGED",
      "count": 15
    },
    {
      "term": "HEADACHE",
      "count": 15
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 15
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 14
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 14
    },
    {
      "term": "NEUROTOXICITY",
      "count": 14
    },
    {
      "term": "PAIN",
      "count": 14
    }
  ]
}