{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 4445
    },
    {
      "term": "OFF LABEL USE",
      "count": 3302
    },
    {
      "term": "PYREXIA",
      "count": 2298
    },
    {
      "term": "PNEUMONIA",
      "count": 1581
    },
    {
      "term": "SEPSIS",
      "count": 1492
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 1464
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1307
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 1288
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 1285
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 1197
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 1189
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 1186
    },
    {
      "term": "DIARRHOEA",
      "count": 1156
    },
    {
      "term": "DRUG INTERACTION",
      "count": 1014
    },
    {
      "term": "NEUTROPENIA",
      "count": 985
    },
    {
      "term": "ANAEMIA",
      "count": 941
    },
    {
      "term": "HYPOTENSION",
      "count": 886
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 882
    },
    {
      "term": "RASH",
      "count": 872
    },
    {
      "term": "DYSPNOEA",
      "count": 853
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 818
    },
    {
      "term": "PANCYTOPENIA",
      "count": 815
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 811
    },
    {
      "term": "NAUSEA",
      "count": 754
    },
    {
      "term": "RENAL FAILURE",
      "count": 716
    },
    {
      "term": "VOMITING",
      "count": 702
    },
    {
      "term": "DEATH",
      "count": 664
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 653
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 613
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 584
    },
    {
      "term": "CARDIAC ARREST",
      "count": 577
    },
    {
      "term": "INFECTION",
      "count": 568
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 550
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 520
    },
    {
      "term": "LEUKOPENIA",
      "count": 485
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 480
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 478
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 458
    },
    {
      "term": "EOSINOPHILIA",
      "count": 451
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 439
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 435
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 434
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 423
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 413
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 411
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 410
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 408
    },
    {
      "term": "HYPOXIA",
      "count": 408
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 403
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 390
    },
    {
      "term": "TACHYCARDIA",
      "count": 389
    },
    {
      "term": "MALAISE",
      "count": 388
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 387
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 386
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 385
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 384
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 378
    },
    {
      "term": "SEIZURE",
      "count": 371
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 369
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 359
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 358
    },
    {
      "term": "FATIGUE",
      "count": 356
    },
    {
      "term": "AGRANULOCYTOSIS",
      "count": 345
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 345
    },
    {
      "term": "ENTEROCOCCAL INFECTION",
      "count": 344
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 340
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE COLITIS",
      "count": 338
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 337
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 333
    },
    {
      "term": "ASTHENIA",
      "count": 324
    },
    {
      "term": "DECREASED APPETITE",
      "count": 321
    },
    {
      "term": "ERYTHEMA",
      "count": 315
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 312
    },
    {
      "term": "PSEUDOMONAS INFECTION",
      "count": 311
    },
    {
      "term": "PRURITUS",
      "count": 308
    },
    {
      "term": "HYPERTENSION",
      "count": 304
    },
    {
      "term": "MULTI-ORGAN FAILURE",
      "count": 304
    },
    {
      "term": "COVID-19",
      "count": 303
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 301
    },
    {
      "term": "SHOCK",
      "count": 297
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE INFECTION",
      "count": 296
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 295
    },
    {
      "term": "PAIN",
      "count": 293
    },
    {
      "term": "CHILLS",
      "count": 289
    },
    {
      "term": "CHOLESTASIS",
      "count": 289
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 289
    },
    {
      "term": "COUGH",
      "count": 287
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 285
    },
    {
      "term": "HEADACHE",
      "count": 279
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 277
    },
    {
      "term": "BACTERAEMIA",
      "count": 277
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 277
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 275
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 274
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 271
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 268
    },
    {
      "term": "SYSTEMIC CANDIDA",
      "count": 264
    },
    {
      "term": "DRUG ERUPTION",
      "count": 260
    },
    {
      "term": "HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS",
      "count": 260
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 255
    }
  ]
}