{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 206
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 170
    },
    {
      "term": "FATIGUE",
      "count": 147
    },
    {
      "term": "NAUSEA",
      "count": 134
    },
    {
      "term": "NEUTROPENIA",
      "count": 126
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 121
    },
    {
      "term": "DEATH",
      "count": 103
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 98
    },
    {
      "term": "VOMITING",
      "count": 77
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 75
    },
    {
      "term": "HEADACHE",
      "count": 72
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 72
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 72
    },
    {
      "term": "ANAEMIA",
      "count": 63
    },
    {
      "term": "DIARRHOEA",
      "count": 60
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 56
    },
    {
      "term": "SEIZURE",
      "count": 54
    },
    {
      "term": "ASTHENIA",
      "count": 52
    },
    {
      "term": "CONSTIPATION",
      "count": 50
    },
    {
      "term": "PNEUMONIA",
      "count": 46
    },
    {
      "term": "PYREXIA",
      "count": 46
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 43
    },
    {
      "term": "RASH",
      "count": 42
    },
    {
      "term": "SEPSIS",
      "count": 42
    },
    {
      "term": "DECREASED APPETITE",
      "count": 40
    },
    {
      "term": "GLIOBLASTOMA",
      "count": 40
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 40
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 39
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 37
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 36
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 36
    },
    {
      "term": "PANCYTOPENIA",
      "count": 36
    },
    {
      "term": "INFECTION",
      "count": 35
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 34
    },
    {
      "term": "LEUKOPENIA",
      "count": 34
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 34
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 33
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 32
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 31
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 28
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 28
    },
    {
      "term": "DYSPNOEA",
      "count": 27
    },
    {
      "term": "EASTERN COOPERATIVE ONCOLOGY GROUP PERFORMANCE STATUS WORSENED",
      "count": 27
    },
    {
      "term": "HYPERTENSION",
      "count": 27
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 25
    },
    {
      "term": "PAIN",
      "count": 25
    },
    {
      "term": "TUMOUR PSEUDOPROGRESSION",
      "count": 25
    },
    {
      "term": "TYPE 2 DIABETES MELLITUS",
      "count": 25
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 24
    },
    {
      "term": "NEUROTOXICITY",
      "count": 24
    },
    {
      "term": "PRURITUS",
      "count": 24
    },
    {
      "term": "SECOND PRIMARY MALIGNANCY",
      "count": 24
    },
    {
      "term": "CONVULSION",
      "count": 23
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 23
    },
    {
      "term": "HEMIPARESIS",
      "count": 23
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 23
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 23
    },
    {
      "term": "BLOOD COUNT ABNORMAL",
      "count": 22
    },
    {
      "term": "MALAISE",
      "count": 21
    },
    {
      "term": "OSTEONECROSIS",
      "count": 21
    },
    {
      "term": "COGNITIVE DISORDER",
      "count": 20
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 20
    },
    {
      "term": "LYMPHOPENIA",
      "count": 20
    },
    {
      "term": "ARTHRALGIA",
      "count": 19
    },
    {
      "term": "DIZZINESS",
      "count": 19
    },
    {
      "term": "SPEECH DISORDER",
      "count": 19
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 18
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 18
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 18
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 18
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 18
    },
    {
      "term": "OTOTOXICITY",
      "count": 18
    },
    {
      "term": "FALL",
      "count": 17
    },
    {
      "term": "HEPATITIS CHOLESTATIC",
      "count": 17
    },
    {
      "term": "HYPOTENSION",
      "count": 17
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 17
    },
    {
      "term": "SOMNOLENCE",
      "count": 17
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 16
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 16
    },
    {
      "term": "VISUAL IMPAIRMENT",
      "count": 16
    },
    {
      "term": "DEHYDRATION",
      "count": 15
    },
    {
      "term": "DYSARTHRIA",
      "count": 15
    },
    {
      "term": "HEART RATE DECREASED",
      "count": 15
    },
    {
      "term": "MOBILITY DECREASED",
      "count": 15
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 15
    },
    {
      "term": "PARAESTHESIA",
      "count": 15
    },
    {
      "term": "RADIATION NECROSIS",
      "count": 15
    },
    {
      "term": "URTICARIA",
      "count": 15
    },
    {
      "term": "VENOOCCLUSIVE LIVER DISEASE",
      "count": 15
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 15
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 14
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 14
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 14
    },
    {
      "term": "REBOUND EFFECT",
      "count": 14
    },
    {
      "term": "THROMBOSIS",
      "count": 14
    },
    {
      "term": "CARDIOMYOPATHY",
      "count": 13
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 13
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 13
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 13
    },
    {
      "term": "PROTEINURIA",
      "count": 13
    }
  ]
}