{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 2268
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 1833
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 1788
    },
    {
      "term": "ANAEMIA",
      "count": 1460
    },
    {
      "term": "DRUG INTERACTION",
      "count": 1208
    },
    {
      "term": "NAUSEA",
      "count": 1001
    },
    {
      "term": "LACTIC ACIDOSIS",
      "count": 904
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 870
    },
    {
      "term": "VOMITING",
      "count": 864
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 858
    },
    {
      "term": "PYREXIA",
      "count": 830
    },
    {
      "term": "SEROTONIN SYNDROME",
      "count": 801
    },
    {
      "term": "PANCYTOPENIA",
      "count": 760
    },
    {
      "term": "DIARRHOEA",
      "count": 741
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 723
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 690
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 660
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 654
    },
    {
      "term": "DYSPNOEA",
      "count": 623
    },
    {
      "term": "DEATH",
      "count": 570
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 559
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 544
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 544
    },
    {
      "term": "PNEUMONIA",
      "count": 540
    },
    {
      "term": "SEPSIS",
      "count": 531
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 488
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 479
    },
    {
      "term": "HYPOTENSION",
      "count": 434
    },
    {
      "term": "ASTHENIA",
      "count": 427
    },
    {
      "term": "NEUTROPENIA",
      "count": 420
    },
    {
      "term": "RENAL FAILURE",
      "count": 386
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 384
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 379
    },
    {
      "term": "RASH",
      "count": 379
    },
    {
      "term": "DECREASED APPETITE",
      "count": 371
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 371
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 341
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 340
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 330
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 314
    },
    {
      "term": "PATHOGEN RESISTANCE",
      "count": 314
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 300
    },
    {
      "term": "LEUKOPENIA",
      "count": 289
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 285
    },
    {
      "term": "DIZZINESS",
      "count": 275
    },
    {
      "term": "HEADACHE",
      "count": 269
    },
    {
      "term": "FATIGUE",
      "count": 267
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 258
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 254
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 253
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 250
    },
    {
      "term": "STAPHYLOCOCCAL INFECTION",
      "count": 250
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 248
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 248
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 237
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 228
    },
    {
      "term": "INFECTION",
      "count": 228
    },
    {
      "term": "ARTHRALGIA",
      "count": 225
    },
    {
      "term": "HYPOGLYCAEMIA",
      "count": 220
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 217
    },
    {
      "term": "EOSINOPHILIA",
      "count": 215
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 210
    },
    {
      "term": "OPTIC NEUROPATHY",
      "count": 210
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 209
    },
    {
      "term": "TACHYCARDIA",
      "count": 209
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 208
    },
    {
      "term": "MALAISE",
      "count": 208
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 202
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 202
    },
    {
      "term": "TUBERCULOSIS",
      "count": 201
    },
    {
      "term": "COUGH",
      "count": 198
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 198
    },
    {
      "term": "ENTEROCOCCAL INFECTION",
      "count": 193
    },
    {
      "term": "PRURITUS",
      "count": 193
    },
    {
      "term": "HYPERTENSION",
      "count": 190
    },
    {
      "term": "CARDIAC ARREST",
      "count": 187
    },
    {
      "term": "PARAESTHESIA",
      "count": 184
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 183
    },
    {
      "term": "ERYTHEMA",
      "count": 172
    },
    {
      "term": "OPTIC NEURITIS",
      "count": 171
    },
    {
      "term": "SEIZURE",
      "count": 170
    },
    {
      "term": "TREMOR",
      "count": 169
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 168
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 167
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 165
    },
    {
      "term": "HALLUCINATION",
      "count": 164
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 162
    },
    {
      "term": "POLYNEUROPATHY",
      "count": 161
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 160
    },
    {
      "term": "COVID-19",
      "count": 159
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 159
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 157
    },
    {
      "term": "PAIN",
      "count": 157
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 155
    },
    {
      "term": "VISUAL IMPAIRMENT",
      "count": 153
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 150
    },
    {
      "term": "CHOLESTASIS",
      "count": 149
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 149
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 146
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 145
    }
  ]
}