{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 25
    },
    {
      "term": "FATIGUE",
      "count": 23
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 15
    },
    {
      "term": "NAUSEA",
      "count": 15
    },
    {
      "term": "OFF LABEL USE",
      "count": 15
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 14
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 12
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 11
    },
    {
      "term": "RASH",
      "count": 11
    },
    {
      "term": "VOMITING",
      "count": 10
    },
    {
      "term": "GLIOBLASTOMA",
      "count": 8
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 8
    },
    {
      "term": "ANAEMIA",
      "count": 7
    },
    {
      "term": "DEATH",
      "count": 7
    },
    {
      "term": "DIZZINESS",
      "count": 7
    },
    {
      "term": "GLIOBLASTOMA MULTIFORME",
      "count": 7
    },
    {
      "term": "DIARRHOEA",
      "count": 6
    },
    {
      "term": "LIVER FUNCTION TEST INCREASED",
      "count": 6
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 5
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 5
    },
    {
      "term": "CONSTIPATION",
      "count": 5
    },
    {
      "term": "GLIOMA",
      "count": 5
    },
    {
      "term": "NEUTROPENIA",
      "count": 5
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 4
    },
    {
      "term": "ARTHRALGIA",
      "count": 4
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 4
    },
    {
      "term": "ASTROCYTOMA",
      "count": 4
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 4
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 4
    },
    {
      "term": "DRY MOUTH",
      "count": 4
    },
    {
      "term": "HEADACHE",
      "count": 4
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 4
    },
    {
      "term": "NEUROTOXICITY",
      "count": 4
    },
    {
      "term": "OEDEMA",
      "count": 4
    },
    {
      "term": "SARCOMA",
      "count": 4
    },
    {
      "term": "VERTIGO",
      "count": 4
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 3
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 3
    },
    {
      "term": "COVID-19",
      "count": 3
    },
    {
      "term": "DRY EYE",
      "count": 3
    },
    {
      "term": "DYSGEUSIA",
      "count": 3
    },
    {
      "term": "FEELING COLD",
      "count": 3
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 3
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 3
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 3
    },
    {
      "term": "LEUKOPENIA",
      "count": 3
    },
    {
      "term": "MEMORY IMPAIRMENT",
      "count": 3
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 3
    },
    {
      "term": "METASTASES TO MENINGES",
      "count": 3
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 3
    },
    {
      "term": "MYALGIA",
      "count": 3
    },
    {
      "term": "NEUROLOGICAL DECOMPENSATION",
      "count": 3
    },
    {
      "term": "PAIN",
      "count": 3
    },
    {
      "term": "PERICARDITIS",
      "count": 3
    },
    {
      "term": "PYREXIA",
      "count": 3
    },
    {
      "term": "SEIZURE",
      "count": 3
    },
    {
      "term": "SOMNOLENCE",
      "count": 3
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 3
    },
    {
      "term": "VISUAL IMPAIRMENT",
      "count": 3
    },
    {
      "term": "ADENOID CYSTIC CARCINOMA",
      "count": 2
    },
    {
      "term": "AMYLASE INCREASED",
      "count": 2
    },
    {
      "term": "ASCITES",
      "count": 2
    },
    {
      "term": "ASTROCYTOMA, LOW GRADE",
      "count": 2
    },
    {
      "term": "ATAXIA",
      "count": 2
    },
    {
      "term": "BRAIN FOG",
      "count": 2
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 2
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 2
    },
    {
      "term": "COGNITIVE DISORDER",
      "count": 2
    },
    {
      "term": "CYTOPENIA",
      "count": 2
    },
    {
      "term": "DERMATITIS",
      "count": 2
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 2
    },
    {
      "term": "DRUG RESISTANCE MUTATION",
      "count": 2
    },
    {
      "term": "DYSPHAGIA",
      "count": 2
    },
    {
      "term": "FLUID RETENTION",
      "count": 2
    },
    {
      "term": "GENE MUTATION",
      "count": 2
    },
    {
      "term": "HAEMOLYTIC URAEMIC SYNDROME",
      "count": 2
    },
    {
      "term": "HEPATOCELLULAR INJURY",
      "count": 2
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 2
    },
    {
      "term": "HYDROCEPHALUS",
      "count": 2
    },
    {
      "term": "INFECTION",
      "count": 2
    },
    {
      "term": "INTESTINAL PERFORATION",
      "count": 2
    },
    {
      "term": "IRRITABILITY",
      "count": 2
    },
    {
      "term": "JAUNDICE CHOLESTATIC",
      "count": 2
    },
    {
      "term": "MALIGNANT GLIOMA",
      "count": 2
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 2
    },
    {
      "term": "METASTASIS",
      "count": 2
    },
    {
      "term": "MULTIPLE-DRUG RESISTANCE",
      "count": 2
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 2
    },
    {
      "term": "NEOPLASM MALIGNANT",
      "count": 2
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 2
    },
    {
      "term": "PANCYTOPENIA",
      "count": 2
    },
    {
      "term": "PNEUMONIA",
      "count": 2
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 2
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 2
    },
    {
      "term": "RESPIRATORY DISORDER",
      "count": 2
    },
    {
      "term": "SYNCOPE",
      "count": 2
    },
    {
      "term": "TEMPERATURE INTOLERANCE",
      "count": 2
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 2
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 2
    },
    {
      "term": "URTICARIA",
      "count": 2
    }
  ]
}