{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DIARRHOEA",
      "count": 999
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 598
    },
    {
      "term": "VOMITING",
      "count": 450
    },
    {
      "term": "NAUSEA",
      "count": 437
    },
    {
      "term": "NEUTROPENIA",
      "count": 431
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 356
    },
    {
      "term": "PYREXIA",
      "count": 354
    },
    {
      "term": "FATIGUE",
      "count": 325
    },
    {
      "term": "ASTHENIA",
      "count": 293
    },
    {
      "term": "DYSPNOEA",
      "count": 287
    },
    {
      "term": "DEHYDRATION",
      "count": 278
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 275
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 270
    },
    {
      "term": "RASH",
      "count": 227
    },
    {
      "term": "ANAEMIA",
      "count": 210
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 199
    },
    {
      "term": "OFF LABEL USE",
      "count": 190
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 182
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 166
    },
    {
      "term": "DEATH",
      "count": 164
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 154
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 151
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 150
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 148
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 147
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 144
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 140
    },
    {
      "term": "METASTASES TO BONE",
      "count": 139
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 138
    },
    {
      "term": "HEADACHE",
      "count": 137
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 134
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 129
    },
    {
      "term": "DIZZINESS",
      "count": 125
    },
    {
      "term": "COUGH",
      "count": 119
    },
    {
      "term": "PNEUMONIA",
      "count": 117
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 116
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 116
    },
    {
      "term": "LEUKOPENIA",
      "count": 115
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 113
    },
    {
      "term": "DECREASED APPETITE",
      "count": 112
    },
    {
      "term": "PAIN",
      "count": 108
    },
    {
      "term": "SEPSIS",
      "count": 103
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 98
    },
    {
      "term": "BREAST CANCER",
      "count": 96
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 95
    },
    {
      "term": "STOMATITIS",
      "count": 91
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 86
    },
    {
      "term": "MALAISE",
      "count": 84
    },
    {
      "term": "PARONYCHIA",
      "count": 82
    },
    {
      "term": "INFECTION",
      "count": 78
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 75
    },
    {
      "term": "PRURITUS",
      "count": 75
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 75
    },
    {
      "term": "JAUNDICE",
      "count": 74
    },
    {
      "term": "SKIN TOXICITY",
      "count": 73
    },
    {
      "term": "CHEST PAIN",
      "count": 71
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 71
    },
    {
      "term": "ERYTHEMA",
      "count": 70
    },
    {
      "term": "HYPOTENSION",
      "count": 69
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 69
    },
    {
      "term": "CONSTIPATION",
      "count": 67
    },
    {
      "term": "ALOPECIA",
      "count": 65
    },
    {
      "term": "GASTROINTESTINAL TOXICITY",
      "count": 64
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 64
    },
    {
      "term": "BACK PAIN",
      "count": 63
    },
    {
      "term": "CHILLS",
      "count": 62
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 61
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 61
    },
    {
      "term": "CARDIOTOXICITY",
      "count": 60
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 59
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 59
    },
    {
      "term": "HYPERBILIRUBINAEMIA",
      "count": 57
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 55
    },
    {
      "term": "METASTASES TO SKIN",
      "count": 55
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 54
    },
    {
      "term": "HYPERTENSION",
      "count": 54
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 54
    },
    {
      "term": "ARTHRALGIA",
      "count": 53
    },
    {
      "term": "CELLULITIS",
      "count": 53
    },
    {
      "term": "SKIN FISSURES",
      "count": 53
    },
    {
      "term": "CARDIAC FAILURE CONGESTIVE",
      "count": 49
    },
    {
      "term": "OEDEMA",
      "count": 49
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 48
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 47
    },
    {
      "term": "DYSPHAGIA",
      "count": 47
    },
    {
      "term": "VASCULAR DEVICE INFECTION",
      "count": 46
    },
    {
      "term": "ASCITES",
      "count": 45
    },
    {
      "term": "BRAIN OEDEMA",
      "count": 45
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 45
    },
    {
      "term": "PNEUMONITIS",
      "count": 45
    },
    {
      "term": "EPISTAXIS",
      "count": 44
    },
    {
      "term": "NEUROTOXICITY",
      "count": 44
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 43
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 43
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 43
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 43
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 43
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 42
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 41
    },
    {
      "term": "DRY SKIN",
      "count": 41
    }
  ]
}