{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DIARRHOEA",
      "count": 891
    },
    {
      "term": "OFF LABEL USE",
      "count": 697
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 652
    },
    {
      "term": "NAUSEA",
      "count": 500
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 475
    },
    {
      "term": "VOMITING",
      "count": 430
    },
    {
      "term": "NEUTROPENIA",
      "count": 423
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 351
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 335
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 323
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 302
    },
    {
      "term": "FATIGUE",
      "count": 275
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 274
    },
    {
      "term": "PYREXIA",
      "count": 265
    },
    {
      "term": "DEATH",
      "count": 256
    },
    {
      "term": "DECREASED APPETITE",
      "count": 241
    },
    {
      "term": "ANAEMIA",
      "count": 229
    },
    {
      "term": "ASTHENIA",
      "count": 221
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 213
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 213
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 207
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 199
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 191
    },
    {
      "term": "STOMATITIS",
      "count": 191
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 175
    },
    {
      "term": "DYSPNOEA",
      "count": 167
    },
    {
      "term": "HYPERTENSION",
      "count": 161
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 155
    },
    {
      "term": "SEPSIS",
      "count": 137
    },
    {
      "term": "MALAISE",
      "count": 135
    },
    {
      "term": "DEHYDRATION",
      "count": 129
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 127
    },
    {
      "term": "RASH",
      "count": 127
    },
    {
      "term": "LEUKOPENIA",
      "count": 122
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 119
    },
    {
      "term": "CONSTIPATION",
      "count": 116
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 107
    },
    {
      "term": "PNEUMONIA",
      "count": 106
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 104
    },
    {
      "term": "PANCYTOPENIA",
      "count": 103
    },
    {
      "term": "PARAESTHESIA",
      "count": 103
    },
    {
      "term": "DERMATITIS ACNEIFORM",
      "count": 99
    },
    {
      "term": "HYPOTENSION",
      "count": 98
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 98
    },
    {
      "term": "DYSARTHRIA",
      "count": 93
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 92
    },
    {
      "term": "PAIN",
      "count": 89
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 84
    },
    {
      "term": "HYPOMAGNESAEMIA",
      "count": 84
    },
    {
      "term": "NEUROTOXICITY",
      "count": 84
    },
    {
      "term": "COLON CANCER",
      "count": 83
    },
    {
      "term": "DIZZINESS",
      "count": 83
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 83
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 83
    },
    {
      "term": "ALOPECIA",
      "count": 81
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 81
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 80
    },
    {
      "term": "INFECTION",
      "count": 79
    },
    {
      "term": "INTESTINAL OBSTRUCTION",
      "count": 79
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 78
    },
    {
      "term": "PROTEINURIA",
      "count": 77
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 75
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 75
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 71
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 70
    },
    {
      "term": "PRURITUS",
      "count": 69
    },
    {
      "term": "COLITIS",
      "count": 68
    },
    {
      "term": "HYPERHIDROSIS",
      "count": 68
    },
    {
      "term": "PARONYCHIA",
      "count": 66
    },
    {
      "term": "COLORECTAL CANCER METASTATIC",
      "count": 65
    },
    {
      "term": "EPISTAXIS",
      "count": 65
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 64
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 64
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 63
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 62
    },
    {
      "term": "THROMBOSIS",
      "count": 62
    },
    {
      "term": "ASCITES",
      "count": 60
    },
    {
      "term": "SKIN TOXICITY",
      "count": 60
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 58
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 58
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 58
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 58
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 58
    },
    {
      "term": "HEADACHE",
      "count": 56
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 54
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 52
    },
    {
      "term": "SKIN DISORDER",
      "count": 52
    },
    {
      "term": "DRY SKIN",
      "count": 51
    },
    {
      "term": "BACK PAIN",
      "count": 49
    },
    {
      "term": "CHEST PAIN",
      "count": 47
    },
    {
      "term": "ERYTHEMA",
      "count": 47
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 46
    },
    {
      "term": "INFUSION RELATED REACTION",
      "count": 46
    },
    {
      "term": "PERIPHERAL SENSORY NEUROPATHY",
      "count": 46
    },
    {
      "term": "FALL",
      "count": 44
    },
    {
      "term": "ILEUS",
      "count": 44
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 44
    },
    {
      "term": "INTESTINAL PERFORATION",
      "count": 43
    },
    {
      "term": "SPEECH DISORDER",
      "count": 43
    },
    {
      "term": "TACHYCARDIA",
      "count": 43
    }
  ]
}