{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 1733
    },
    {
      "term": "DIARRHOEA",
      "count": 1558
    },
    {
      "term": "COLITIS",
      "count": 1361
    },
    {
      "term": "PYREXIA",
      "count": 1014
    },
    {
      "term": "DEATH",
      "count": 975
    },
    {
      "term": "FATIGUE",
      "count": 841
    },
    {
      "term": "OFF LABEL USE",
      "count": 822
    },
    {
      "term": "NAUSEA",
      "count": 761
    },
    {
      "term": "PNEUMONITIS",
      "count": 697
    },
    {
      "term": "VOMITING",
      "count": 649
    },
    {
      "term": "HYPOPHYSITIS",
      "count": 647
    },
    {
      "term": "IMMUNE-MEDIATED ENTEROCOLITIS",
      "count": 646
    },
    {
      "term": "RASH",
      "count": 628
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 616
    },
    {
      "term": "DYSPNOEA",
      "count": 612
    },
    {
      "term": "PNEUMONIA",
      "count": 603
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 523
    },
    {
      "term": "DEHYDRATION",
      "count": 492
    },
    {
      "term": "ADRENAL INSUFFICIENCY",
      "count": 484
    },
    {
      "term": "DECREASED APPETITE",
      "count": 469
    },
    {
      "term": "ANAEMIA",
      "count": 458
    },
    {
      "term": "SEPSIS",
      "count": 447
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 414
    },
    {
      "term": "ASTHENIA",
      "count": 401
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 400
    },
    {
      "term": "HEPATITIS",
      "count": 386
    },
    {
      "term": "HEADACHE",
      "count": 364
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 356
    },
    {
      "term": "HYPOTENSION",
      "count": 342
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 336
    },
    {
      "term": "PRURITUS",
      "count": 336
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 329
    },
    {
      "term": "HYPERTHYROIDISM",
      "count": 328
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 314
    },
    {
      "term": "IMMUNE-MEDIATED HEPATITIS",
      "count": 313
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 312
    },
    {
      "term": "MYOCARDITIS",
      "count": 301
    },
    {
      "term": "ARTHRALGIA",
      "count": 289
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 263
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 262
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 261
    },
    {
      "term": "AUTOIMMUNE HEPATITIS",
      "count": 259
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 247
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 234
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 233
    },
    {
      "term": "DIABETIC KETOACIDOSIS",
      "count": 226
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 219
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 214
    },
    {
      "term": "CONSTIPATION",
      "count": 209
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 209
    },
    {
      "term": "MALAISE",
      "count": 206
    },
    {
      "term": "BACK PAIN",
      "count": 200
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 200
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 198
    },
    {
      "term": "TYPE 1 DIABETES MELLITUS",
      "count": 196
    },
    {
      "term": "RENAL FAILURE",
      "count": 195
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 195
    },
    {
      "term": "COUGH",
      "count": 194
    },
    {
      "term": "AUTOIMMUNE COLITIS",
      "count": 191
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 184
    },
    {
      "term": "NEUTROPENIA",
      "count": 183
    },
    {
      "term": "ARTHRITIS",
      "count": 182
    },
    {
      "term": "MYOSITIS",
      "count": 182
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 181
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 181
    },
    {
      "term": "PAIN",
      "count": 180
    },
    {
      "term": "LIPASE INCREASED",
      "count": 178
    },
    {
      "term": "ENTEROCOLITIS",
      "count": 173
    },
    {
      "term": "AUTOIMMUNE DISORDER",
      "count": 170
    },
    {
      "term": "IMMUNE-MEDIATED MYOCARDITIS",
      "count": 169
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 167
    },
    {
      "term": "HYPOPITUITARISM",
      "count": 166
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 166
    },
    {
      "term": "THYROIDITIS",
      "count": 159
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 151
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 150
    },
    {
      "term": "SYNCOPE",
      "count": 148
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 147
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 146
    },
    {
      "term": "PANCREATITIS",
      "count": 144
    },
    {
      "term": "DIZZINESS",
      "count": 142
    },
    {
      "term": "HYPERTENSION",
      "count": 141
    },
    {
      "term": "IMMUNE-MEDIATED LUNG DISEASE",
      "count": 140
    },
    {
      "term": "MYALGIA",
      "count": 139
    },
    {
      "term": "CHILLS",
      "count": 137
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 136
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 135
    },
    {
      "term": "FALL",
      "count": 134
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 134
    },
    {
      "term": "LIVER DISORDER",
      "count": 132
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 131
    },
    {
      "term": "METASTATIC MALIGNANT MELANOMA",
      "count": 131
    },
    {
      "term": "TUBULOINTERSTITIAL NEPHRITIS",
      "count": 130
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 127
    },
    {
      "term": "SEIZURE",
      "count": 124
    },
    {
      "term": "DERMATITIS",
      "count": 121
    },
    {
      "term": "PANCYTOPENIA",
      "count": 121
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 119
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 119
    },
    {
      "term": "HYPOXIA",
      "count": 116
    }
  ]
}