{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DEPENDENCE",
      "count": 825
    },
    {
      "term": "OVERDOSE",
      "count": 461
    },
    {
      "term": "DEATH",
      "count": 183
    },
    {
      "term": "DEPRESSION",
      "count": 47
    },
    {
      "term": "ILL-DEFINED DISORDER",
      "count": 41
    },
    {
      "term": "WITHDRAWAL SYNDROME",
      "count": 35
    },
    {
      "term": "ANXIETY",
      "count": 32
    },
    {
      "term": "SUICIDE ATTEMPT",
      "count": 17
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 14
    },
    {
      "term": "PRODUCT PRESCRIBING ISSUE",
      "count": 14
    },
    {
      "term": "CONSTIPATION",
      "count": 12
    },
    {
      "term": "AMNESIA",
      "count": 10
    },
    {
      "term": "NAUSEA",
      "count": 10
    },
    {
      "term": "PAIN",
      "count": 10
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 9
    },
    {
      "term": "INSOMNIA",
      "count": 9
    },
    {
      "term": "DISABILITY",
      "count": 8
    },
    {
      "term": "DIZZINESS",
      "count": 8
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 8
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 8
    },
    {
      "term": "POST-TRAUMATIC STRESS DISORDER",
      "count": 8
    },
    {
      "term": "VOMITING",
      "count": 8
    },
    {
      "term": "DRUG WITHDRAWAL SYNDROME NEONATAL",
      "count": 7
    },
    {
      "term": "FATIGUE",
      "count": 7
    },
    {
      "term": "MYOCARDIAL INFARCTION",
      "count": 7
    },
    {
      "term": "OFF LABEL USE",
      "count": 7
    },
    {
      "term": "BRAIN INJURY",
      "count": 6
    },
    {
      "term": "CARDIAC DISORDER",
      "count": 6
    },
    {
      "term": "COUGH",
      "count": 6
    },
    {
      "term": "HEPATITIS C",
      "count": 6
    },
    {
      "term": "HYPERAESTHESIA",
      "count": 6
    },
    {
      "term": "LIQUID PRODUCT PHYSICAL ISSUE",
      "count": 6
    },
    {
      "term": "MENTAL DISORDER",
      "count": 6
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 6
    },
    {
      "term": "STRESS",
      "count": 6
    },
    {
      "term": "SUICIDAL IDEATION",
      "count": 6
    },
    {
      "term": "TOOTH LOSS",
      "count": 6
    },
    {
      "term": "COMPLETED SUICIDE",
      "count": 5
    },
    {
      "term": "DIARRHOEA",
      "count": 5
    },
    {
      "term": "DRUG DIVERSION",
      "count": 5
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 5
    },
    {
      "term": "ILLNESS",
      "count": 5
    },
    {
      "term": "PRODUCT TASTE ABNORMAL",
      "count": 5
    },
    {
      "term": "RESPIRATORY DEPRESSION",
      "count": 5
    },
    {
      "term": "SOMNOLENCE",
      "count": 5
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 4
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 4
    },
    {
      "term": "DRUG DEPENDENCE",
      "count": 4
    },
    {
      "term": "DYSPNOEA",
      "count": 4
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 4
    },
    {
      "term": "LIVER DISORDER",
      "count": 4
    },
    {
      "term": "NEOPLASM MALIGNANT",
      "count": 4
    },
    {
      "term": "PRODUCT QUALITY ISSUE",
      "count": 4
    },
    {
      "term": "ROAD TRAFFIC ACCIDENT",
      "count": 4
    },
    {
      "term": "SUBSTANCE ABUSE",
      "count": 4
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 4
    },
    {
      "term": "ACCIDENTAL OVERDOSE",
      "count": 3
    },
    {
      "term": "AGGRESSION",
      "count": 3
    },
    {
      "term": "ARNOLD-CHIARI MALFORMATION",
      "count": 3
    },
    {
      "term": "ASTHENIA",
      "count": 3
    },
    {
      "term": "ATTENTION DEFICIT HYPERACTIVITY DISORDER",
      "count": 3
    },
    {
      "term": "CARDIAC ARREST",
      "count": 3
    },
    {
      "term": "CHEST PAIN",
      "count": 3
    },
    {
      "term": "DECREASED APPETITE",
      "count": 3
    },
    {
      "term": "EMOTIONAL DISTRESS",
      "count": 3
    },
    {
      "term": "FALL",
      "count": 3
    },
    {
      "term": "HEART RATE INCREASED",
      "count": 3
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 3
    },
    {
      "term": "HYPERTENSION",
      "count": 3
    },
    {
      "term": "HYPOAESTHESIA ORAL",
      "count": 3
    },
    {
      "term": "MALAISE",
      "count": 3
    },
    {
      "term": "MIGRAINE",
      "count": 3
    },
    {
      "term": "MOOD SWINGS",
      "count": 3
    },
    {
      "term": "NIGHTMARE",
      "count": 3
    },
    {
      "term": "PNEUMONIA",
      "count": 3
    },
    {
      "term": "RENAL FAILURE",
      "count": 3
    },
    {
      "term": "SPINA BIFIDA",
      "count": 3
    },
    {
      "term": "TOOTH DISORDER",
      "count": 3
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 2
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 2
    },
    {
      "term": "AFFECTIVE DISORDER",
      "count": 2
    },
    {
      "term": "ANGER",
      "count": 2
    },
    {
      "term": "ASTHMA",
      "count": 2
    },
    {
      "term": "BACK PAIN",
      "count": 2
    },
    {
      "term": "BLOOD GLUCOSE INCREASED",
      "count": 2
    },
    {
      "term": "BREATHING-RELATED SLEEP DISORDER",
      "count": 2
    },
    {
      "term": "COGNITIVE DISORDER",
      "count": 2
    },
    {
      "term": "COMA",
      "count": 2
    },
    {
      "term": "CRANIOCEREBRAL INJURY",
      "count": 2
    },
    {
      "term": "DISTURBANCE IN ATTENTION",
      "count": 2
    },
    {
      "term": "DRUG ABUSE",
      "count": 2
    },
    {
      "term": "DRUG EFFECT LESS THAN EXPECTED",
      "count": 2
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 2
    },
    {
      "term": "DRUG TOLERANCE INCREASED",
      "count": 2
    },
    {
      "term": "DRY MOUTH",
      "count": 2
    },
    {
      "term": "DYSGEUSIA",
      "count": 2
    },
    {
      "term": "EUPHORIC MOOD",
      "count": 2
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 2
    },
    {
      "term": "GASTROOESOPHAGEAL REFLUX DISEASE",
      "count": 2
    },
    {
      "term": "HEADACHE",
      "count": 2
    }
  ]
}