{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DISEASE PROGRESSION",
      "count": 5002
    },
    {
      "term": "OFF LABEL USE",
      "count": 4419
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 4047
    },
    {
      "term": "NEUTROPENIA",
      "count": 3627
    },
    {
      "term": "ANAEMIA",
      "count": 3408
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 3044
    },
    {
      "term": "NAUSEA",
      "count": 2902
    },
    {
      "term": "PYREXIA",
      "count": 2898
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 2822
    },
    {
      "term": "VOMITING",
      "count": 2326
    },
    {
      "term": "DIARRHOEA",
      "count": 2287
    },
    {
      "term": "FATIGUE",
      "count": 2241
    },
    {
      "term": "DEATH",
      "count": 2069
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 1934
    },
    {
      "term": "DYSPNOEA",
      "count": 1823
    },
    {
      "term": "ASTHENIA",
      "count": 1694
    },
    {
      "term": "PNEUMONIA",
      "count": 1619
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 1560
    },
    {
      "term": "PANCYTOPENIA",
      "count": 1439
    },
    {
      "term": "SEPSIS",
      "count": 1351
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 1336
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 1334
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 1333
    },
    {
      "term": "LEUKOPENIA",
      "count": 1320
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 1186
    },
    {
      "term": "DECREASED APPETITE",
      "count": 1178
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 1114
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 1087
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1067
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 1047
    },
    {
      "term": "RASH",
      "count": 999
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 999
    },
    {
      "term": "DEHYDRATION",
      "count": 971
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 939
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 902
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 882
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 859
    },
    {
      "term": "CONSTIPATION",
      "count": 856
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 844
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 768
    },
    {
      "term": "INFECTION",
      "count": 764
    },
    {
      "term": "PAIN",
      "count": 749
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 722
    },
    {
      "term": "HYPOTENSION",
      "count": 706
    },
    {
      "term": "ASCITES",
      "count": 662
    },
    {
      "term": "HYPERTENSION",
      "count": 649
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 641
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 638
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 637
    },
    {
      "term": "COUGH",
      "count": 631
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 625
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 619
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 607
    },
    {
      "term": "PNEUMONITIS",
      "count": 604
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 604
    },
    {
      "term": "RENAL FAILURE",
      "count": 595
    },
    {
      "term": "DIZZINESS",
      "count": 590
    },
    {
      "term": "MALAISE",
      "count": 590
    },
    {
      "term": "CHOLANGITIS",
      "count": 580
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 579
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 559
    },
    {
      "term": "CHILLS",
      "count": 545
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 538
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 516
    },
    {
      "term": "ERYTHEMA",
      "count": 516
    },
    {
      "term": "PRURITUS",
      "count": 513
    },
    {
      "term": "HEADACHE",
      "count": 501
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 501
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 495
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 477
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 476
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 466
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 459
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 456
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 451
    },
    {
      "term": "CHEST PAIN",
      "count": 449
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 439
    },
    {
      "term": "NEUTROPENIC SEPSIS",
      "count": 435
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 434
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 426
    },
    {
      "term": "ALOPECIA",
      "count": 425
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 425
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 422
    },
    {
      "term": "NEUROTOXICITY",
      "count": 415
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 412
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA",
      "count": 410
    },
    {
      "term": "EPISTAXIS",
      "count": 408
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 405
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 399
    },
    {
      "term": "CYTOPENIA",
      "count": 383
    },
    {
      "term": "BACK PAIN",
      "count": 377
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA RECURRENT",
      "count": 376
    },
    {
      "term": "TACHYCARDIA",
      "count": 374
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 366
    },
    {
      "term": "BLOOD LACTATE DEHYDROGENASE INCREASED",
      "count": 365
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 360
    },
    {
      "term": "COLITIS",
      "count": 360
    },
    {
      "term": "PARAESTHESIA",
      "count": 358
    },
    {
      "term": "STOMATITIS",
      "count": 356
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 356
    }
  ]
}