{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 610
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 488
    },
    {
      "term": "ACQUIRED GENE MUTATION",
      "count": 219
    },
    {
      "term": "DIARRHOEA",
      "count": 172
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 147
    },
    {
      "term": "RASH",
      "count": 142
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 112
    },
    {
      "term": "EGFR GENE MUTATION",
      "count": 109
    },
    {
      "term": "DEATH",
      "count": 107
    },
    {
      "term": "NAUSEA",
      "count": 93
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 86
    },
    {
      "term": "OFF LABEL USE",
      "count": 85
    },
    {
      "term": "FATIGUE",
      "count": 77
    },
    {
      "term": "VOMITING",
      "count": 73
    },
    {
      "term": "MALIGNANT TRANSFORMATION",
      "count": 64
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 62
    },
    {
      "term": "METASTASES TO BONE",
      "count": 58
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 57
    },
    {
      "term": "METASTASES TO MENINGES",
      "count": 57
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 56
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 56
    },
    {
      "term": "ANAEMIA",
      "count": 55
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 53
    },
    {
      "term": "PARONYCHIA",
      "count": 53
    },
    {
      "term": "NEUTROPENIA",
      "count": 52
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 50
    },
    {
      "term": "DRUG INTERACTION",
      "count": 46
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 46
    },
    {
      "term": "DECREASED APPETITE",
      "count": 43
    },
    {
      "term": "ASTHENIA",
      "count": 41
    },
    {
      "term": "DYSPNOEA",
      "count": 41
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 40
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 39
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 38
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 37
    },
    {
      "term": "PNEUMONIA",
      "count": 36
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 35
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 34
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 32
    },
    {
      "term": "PNEUMONITIS",
      "count": 32
    },
    {
      "term": "HYPERTENSION",
      "count": 31
    },
    {
      "term": "PYREXIA",
      "count": 30
    },
    {
      "term": "LEUKOPENIA",
      "count": 29
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 26
    },
    {
      "term": "FALL",
      "count": 25
    },
    {
      "term": "GENE MUTATION",
      "count": 25
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 25
    },
    {
      "term": "PRURITUS",
      "count": 25
    },
    {
      "term": "PROTEINURIA",
      "count": 24
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 24
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 23
    },
    {
      "term": "COUGH",
      "count": 23
    },
    {
      "term": "HEPATITIS",
      "count": 23
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 22
    },
    {
      "term": "DEHYDRATION",
      "count": 22
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 22
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 22
    },
    {
      "term": "SKIN TOXICITY",
      "count": 22
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 22
    },
    {
      "term": "SMALL CELL LUNG CANCER",
      "count": 21
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 21
    },
    {
      "term": "CHEST PAIN",
      "count": 20
    },
    {
      "term": "ERYTHEMA",
      "count": 20
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 20
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 19
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 19
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 19
    },
    {
      "term": "METASTASIS",
      "count": 19
    },
    {
      "term": "DERMATITIS ACNEIFORM",
      "count": 18
    },
    {
      "term": "HAEMOPTYSIS",
      "count": 18
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 18
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 17
    },
    {
      "term": "PAIN",
      "count": 17
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 17
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 17
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 16
    },
    {
      "term": "DIZZINESS",
      "count": 16
    },
    {
      "term": "MOUTH ULCERATION",
      "count": 16
    },
    {
      "term": "SKIN DISORDER",
      "count": 16
    },
    {
      "term": "SQUAMOUS CELL CARCINOMA",
      "count": 16
    },
    {
      "term": "ALOPECIA",
      "count": 15
    },
    {
      "term": "HEADACHE",
      "count": 15
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 15
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 15
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 15
    },
    {
      "term": "STOMATITIS",
      "count": 15
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 15
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 14
    },
    {
      "term": "DRY SKIN",
      "count": 14
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 14
    },
    {
      "term": "HAEMORRHAGE",
      "count": 14
    },
    {
      "term": "INFECTION",
      "count": 14
    },
    {
      "term": "METASTASES TO PLEURA",
      "count": 14
    },
    {
      "term": "CONVULSION",
      "count": 13
    },
    {
      "term": "DYSPHAGIA",
      "count": 13
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 13
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 13
    },
    {
      "term": "LIVER INJURY",
      "count": 13
    },
    {
      "term": "MULTIPLE-DRUG RESISTANCE",
      "count": 13
    },
    {
      "term": "NERVOUS SYSTEM DISORDER",
      "count": 13
    }
  ]
}