{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DEATH",
      "count": 795
    },
    {
      "term": "FATIGUE",
      "count": 414
    },
    {
      "term": "COLORECTAL CANCER METASTATIC",
      "count": 351
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 239
    },
    {
      "term": "COLON CANCER",
      "count": 234
    },
    {
      "term": "DIARRHOEA",
      "count": 230
    },
    {
      "term": "ASTHENIA",
      "count": 215
    },
    {
      "term": "DYSPHONIA",
      "count": 191
    },
    {
      "term": "DECREASED APPETITE",
      "count": 187
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 174
    },
    {
      "term": "OFF LABEL USE",
      "count": 150
    },
    {
      "term": "NAUSEA",
      "count": 148
    },
    {
      "term": "PAIN",
      "count": 137
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 120
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 108
    },
    {
      "term": "HEADACHE",
      "count": 107
    },
    {
      "term": "VOMITING",
      "count": 102
    },
    {
      "term": "RECTAL CANCER",
      "count": 91
    },
    {
      "term": "HYPERTENSION",
      "count": 90
    },
    {
      "term": "CONSTIPATION",
      "count": 83
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 82
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 81
    },
    {
      "term": "STOMATITIS",
      "count": 77
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 75
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 73
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 72
    },
    {
      "term": "DYSPNOEA",
      "count": 71
    },
    {
      "term": "ARTHRALGIA",
      "count": 66
    },
    {
      "term": "DEHYDRATION",
      "count": 66
    },
    {
      "term": "MALAISE",
      "count": 60
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 59
    },
    {
      "term": "BACK PAIN",
      "count": 59
    },
    {
      "term": "DIZZINESS",
      "count": 57
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 51
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 51
    },
    {
      "term": "DRY SKIN",
      "count": 49
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 49
    },
    {
      "term": "RASH",
      "count": 48
    },
    {
      "term": "COUGH",
      "count": 46
    },
    {
      "term": "ILLNESS",
      "count": 45
    },
    {
      "term": "MYALGIA",
      "count": 44
    },
    {
      "term": "PYREXIA",
      "count": 44
    },
    {
      "term": "SOMNOLENCE",
      "count": 43
    },
    {
      "term": "ORAL PAIN",
      "count": 42
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 41
    },
    {
      "term": "BLISTER",
      "count": 37
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 37
    },
    {
      "term": "OROPHARYNGEAL PAIN",
      "count": 37
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 36
    },
    {
      "term": "PROTEINURIA",
      "count": 35
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 34
    },
    {
      "term": "FEELING ABNORMAL",
      "count": 34
    },
    {
      "term": "PERIPHERAL SWELLING",
      "count": 34
    },
    {
      "term": "PNEUMONIA",
      "count": 34
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 33
    },
    {
      "term": "DRY MOUTH",
      "count": 31
    },
    {
      "term": "FALL",
      "count": 31
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 31
    },
    {
      "term": "HOSPITALISATION",
      "count": 31
    },
    {
      "term": "ABDOMINAL DISTENSION",
      "count": 30
    },
    {
      "term": "ASCITES",
      "count": 29
    },
    {
      "term": "EPISTAXIS",
      "count": 29
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 28
    },
    {
      "term": "APHONIA",
      "count": 27
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 27
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 26
    },
    {
      "term": "INSOMNIA",
      "count": 26
    },
    {
      "term": "PRURITUS",
      "count": 26
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 25
    },
    {
      "term": "COLON CANCER METASTATIC",
      "count": 24
    },
    {
      "term": "INFECTION",
      "count": 24
    },
    {
      "term": "CHEST PAIN",
      "count": 23
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 23
    },
    {
      "term": "HYPOAESTHESIA",
      "count": 23
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 23
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 22
    },
    {
      "term": "SKIN EXFOLIATION",
      "count": 22
    },
    {
      "term": "LIVER DISORDER",
      "count": 21
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 21
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 21
    },
    {
      "term": "BLOOD PRESSURE ABNORMAL",
      "count": 20
    },
    {
      "term": "DYSPHAGIA",
      "count": 20
    },
    {
      "term": "HAEMORRHAGE",
      "count": 20
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 20
    },
    {
      "term": "ERYTHEMA",
      "count": 19
    },
    {
      "term": "RECTAL HAEMORRHAGE",
      "count": 19
    },
    {
      "term": "SEIZURE",
      "count": 19
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 18
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 18
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 18
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 17
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 17
    },
    {
      "term": "FLATULENCE",
      "count": 17
    },
    {
      "term": "MEMORY IMPAIRMENT",
      "count": 17
    },
    {
      "term": "MUSCULAR WEAKNESS",
      "count": 17
    },
    {
      "term": "ADENOCARCINOMA OF COLON",
      "count": 16
    },
    {
      "term": "CARCINOEMBRYONIC ANTIGEN INCREASED",
      "count": 16
    },
    {
      "term": "CHILLS",
      "count": 16
    },
    {
      "term": "GAIT INABILITY",
      "count": 16
    },
    {
      "term": "HAEMATOCHEZIA",
      "count": 16
    }
  ]
}