{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 128
    },
    {
      "term": "OFF LABEL USE",
      "count": 77
    },
    {
      "term": "STATUS EPILEPTICUS",
      "count": 57
    },
    {
      "term": "CARDIAC ARREST",
      "count": 46
    },
    {
      "term": "HYPOTENSION",
      "count": 40
    },
    {
      "term": "PYREXIA",
      "count": 36
    },
    {
      "term": "SEIZURE",
      "count": 36
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 30
    },
    {
      "term": "DRUG INTERACTION",
      "count": 28
    },
    {
      "term": "CONVULSION",
      "count": 27
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 26
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 26
    },
    {
      "term": "ALTERED STATE OF CONSCIOUSNESS",
      "count": 25
    },
    {
      "term": "RESPIRATORY DEPRESSION",
      "count": 23
    },
    {
      "term": "COMA",
      "count": 22
    },
    {
      "term": "DRUG ERUPTION",
      "count": 22
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 22
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 22
    },
    {
      "term": "BRADYCARDIA",
      "count": 21
    },
    {
      "term": "MEDICATION ERROR",
      "count": 20
    },
    {
      "term": "OVERDOSE",
      "count": 20
    },
    {
      "term": "ERYTHEMA",
      "count": 19
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 18
    },
    {
      "term": "RASH",
      "count": 18
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 18
    },
    {
      "term": "PNEUMONIA",
      "count": 17
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 17
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 17
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 17
    },
    {
      "term": "CARDIO-RESPIRATORY ARREST",
      "count": 16
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 16
    },
    {
      "term": "NYSTAGMUS",
      "count": 16
    },
    {
      "term": "SOMNOLENCE",
      "count": 16
    },
    {
      "term": "STEVENS-JOHNSON SYNDROME",
      "count": 16
    },
    {
      "term": "ANTICONVULSANT DRUG LEVEL BELOW THERAPEUTIC",
      "count": 15
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 15
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 14
    },
    {
      "term": "INFUSION SITE EXTRAVASATION",
      "count": 14
    },
    {
      "term": "RESPIRATORY ARREST",
      "count": 14
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 14
    },
    {
      "term": "CARDIOGENIC SHOCK",
      "count": 13
    },
    {
      "term": "DEATH",
      "count": 13
    },
    {
      "term": "DEPRESSED LEVEL OF CONSCIOUSNESS",
      "count": 13
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 13
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 13
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 13
    },
    {
      "term": "PRURITUS",
      "count": 13
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 12
    },
    {
      "term": "NAUSEA",
      "count": 12
    },
    {
      "term": "PNEUMONIA ASPIRATION",
      "count": 12
    },
    {
      "term": "TOXIC EPIDERMAL NECROLYSIS",
      "count": 12
    },
    {
      "term": "ACCIDENTAL OVERDOSE",
      "count": 11
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 11
    },
    {
      "term": "BRAIN OEDEMA",
      "count": 11
    },
    {
      "term": "DYSKINESIA",
      "count": 11
    },
    {
      "term": "EPILEPSY",
      "count": 11
    },
    {
      "term": "SEPSIS",
      "count": 11
    },
    {
      "term": "TACHYCARDIA",
      "count": 11
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 11
    },
    {
      "term": "VOMITING",
      "count": 11
    },
    {
      "term": "AGITATION",
      "count": 10
    },
    {
      "term": "CEREBRAL INFARCTION",
      "count": 10
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 10
    },
    {
      "term": "DYSPNOEA",
      "count": 10
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 10
    },
    {
      "term": "MULTI-ORGAN FAILURE",
      "count": 10
    },
    {
      "term": "RENAL FAILURE",
      "count": 10
    },
    {
      "term": "RESPIRATORY SYMPTOM",
      "count": 10
    },
    {
      "term": "THERAPEUTIC PRODUCT EFFECT INCOMPLETE",
      "count": 10
    },
    {
      "term": "ANAEMIA",
      "count": 9
    },
    {
      "term": "ANTICONVULSANT DRUG LEVEL INCREASED",
      "count": 9
    },
    {
      "term": "APNOEA",
      "count": 9
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 9
    },
    {
      "term": "ATRIOVENTRICULAR BLOCK",
      "count": 9
    },
    {
      "term": "HISTIOCYTOSIS HAEMATOPHAGIC",
      "count": 9
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 9
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 9
    },
    {
      "term": "APHASIA",
      "count": 8
    },
    {
      "term": "DIARRHOEA",
      "count": 8
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 8
    },
    {
      "term": "INFECTION",
      "count": 8
    },
    {
      "term": "LOSS OF CONSCIOUSNESS",
      "count": 8
    },
    {
      "term": "MULTIPLE-DRUG RESISTANCE",
      "count": 8
    },
    {
      "term": "PURPLE GLOVE SYNDROME",
      "count": 8
    },
    {
      "term": "SINUS ARREST",
      "count": 8
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 8
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 7
    },
    {
      "term": "ACUTE RESPIRATORY DISTRESS SYNDROME",
      "count": 7
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 7
    },
    {
      "term": "BLISTER",
      "count": 7
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 7
    },
    {
      "term": "BLOOD GLUCOSE INCREASED",
      "count": 7
    },
    {
      "term": "COAGULOPATHY",
      "count": 7
    },
    {
      "term": "DELIRIUM",
      "count": 7
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 7
    },
    {
      "term": "DIZZINESS",
      "count": 7
    },
    {
      "term": "DRUG HYPERSENSITIVITY",
      "count": 7
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 7
    },
    {
      "term": "HAEMODIALYSIS",
      "count": 7
    },
    {
      "term": "HEMIPLEGIA",
      "count": 7
    }
  ]
}