{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "DRUG INEFFECTIVE",
      "count": 450
    },
    {
      "term": "OFF LABEL USE",
      "count": 130
    },
    {
      "term": "IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME",
      "count": 107
    },
    {
      "term": "MENINGITIS CRYPTOCOCCAL",
      "count": 96
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 89
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 78
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 72
    },
    {
      "term": "CRYPTOCOCCOSIS",
      "count": 70
    },
    {
      "term": "PYREXIA",
      "count": 63
    },
    {
      "term": "DISSEMINATED CRYPTOCOCCOSIS",
      "count": 61
    },
    {
      "term": "HEADACHE",
      "count": 61
    },
    {
      "term": "RENAL FAILURE",
      "count": 60
    },
    {
      "term": "DRUG INTERACTION",
      "count": 52
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 47
    },
    {
      "term": "NEUTROPENIA",
      "count": 45
    },
    {
      "term": "VOMITING",
      "count": 43
    },
    {
      "term": "NAUSEA",
      "count": 42
    },
    {
      "term": "PANCYTOPENIA",
      "count": 41
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 36
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 35
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 34
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 33
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 32
    },
    {
      "term": "ISCHAEMIC STROKE",
      "count": 31
    },
    {
      "term": "CEREBRAL INFARCTION",
      "count": 29
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 29
    },
    {
      "term": "PNEUMONITIS",
      "count": 29
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 29
    },
    {
      "term": "DEATH",
      "count": 28
    },
    {
      "term": "ENCEPHALITIS",
      "count": 26
    },
    {
      "term": "IMMUNE RECONSTITUTION SYNDROME",
      "count": 26
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 26
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 26
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 25
    },
    {
      "term": "BRAIN OEDEMA",
      "count": 24
    },
    {
      "term": "DIARRHOEA",
      "count": 24
    },
    {
      "term": "PNEUMONIA",
      "count": 24
    },
    {
      "term": "INTRACRANIAL PRESSURE INCREASED",
      "count": 22
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 22
    },
    {
      "term": "ANAEMIA",
      "count": 21
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 21
    },
    {
      "term": "PNEUMONIA CRYPTOCOCCAL",
      "count": 21
    },
    {
      "term": "CANDIDA INFECTION",
      "count": 19
    },
    {
      "term": "CARDIAC ARREST",
      "count": 19
    },
    {
      "term": "CENTRAL NERVOUS SYSTEM LESION",
      "count": 19
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 19
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 17
    },
    {
      "term": "MENTAL STATUS CHANGES",
      "count": 17
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 16
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 16
    },
    {
      "term": "PRURITUS",
      "count": 16
    },
    {
      "term": "SEPSIS",
      "count": 16
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 15
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 15
    },
    {
      "term": "MENINGITIS",
      "count": 15
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 15
    },
    {
      "term": "BRAIN ABSCESS",
      "count": 14
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 14
    },
    {
      "term": "CARDIO-RESPIRATORY ARREST",
      "count": 14
    },
    {
      "term": "PULMONARY MASS",
      "count": 14
    },
    {
      "term": "RENAL FAILURE ACUTE",
      "count": 14
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 13
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 13
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 13
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 12
    },
    {
      "term": "COGNITIVE DISORDER",
      "count": 12
    },
    {
      "term": "HALLUCINATION, VISUAL",
      "count": 12
    },
    {
      "term": "IMMUNODEFICIENCY",
      "count": 12
    },
    {
      "term": "LYMPHOPENIA",
      "count": 12
    },
    {
      "term": "SHOCK",
      "count": 12
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 11
    },
    {
      "term": "ELECTROLYTE IMBALANCE",
      "count": 11
    },
    {
      "term": "ENTEROCOCCAL INFECTION",
      "count": 11
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 11
    },
    {
      "term": "HALLUCINATION, AUDITORY",
      "count": 11
    },
    {
      "term": "HYPOTENSION",
      "count": 11
    },
    {
      "term": "OSTEOMYELITIS",
      "count": 11
    },
    {
      "term": "SKIN ULCER",
      "count": 11
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 11
    },
    {
      "term": "VENTRICULAR FIBRILLATION",
      "count": 11
    },
    {
      "term": "CRYPTOCOCCAL CUTANEOUS INFECTION",
      "count": 10
    },
    {
      "term": "DECREASED APPETITE",
      "count": 10
    },
    {
      "term": "FALL",
      "count": 10
    },
    {
      "term": "FATIGUE",
      "count": 10
    },
    {
      "term": "HYDROCEPHALUS",
      "count": 10
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 10
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 10
    },
    {
      "term": "RASH",
      "count": 10
    },
    {
      "term": "BLOOD ALKALINE PHOSPHATASE INCREASED",
      "count": 9
    },
    {
      "term": "CARDIOGENIC SHOCK",
      "count": 9
    },
    {
      "term": "CEREBRAL ASPERGILLOSIS",
      "count": 9
    },
    {
      "term": "CRYPTOCOCCAL MENINGOENCEPHALITIS",
      "count": 9
    },
    {
      "term": "CYTOMEGALOVIRUS ENTEROCOLITIS",
      "count": 9
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 9
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 9
    },
    {
      "term": "DISSEMINATED INTRAVASCULAR COAGULATION",
      "count": 9
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 9
    },
    {
      "term": "INFECTION",
      "count": 9
    },
    {
      "term": "LABELLED DRUG-DRUG INTERACTION MEDICATION ERROR",
      "count": 9
    },
    {
      "term": "LIVER INJURY",
      "count": 9
    }
  ]
}