{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 1518
    },
    {
      "term": "OFF LABEL USE",
      "count": 1259
    },
    {
      "term": "DIARRHOEA",
      "count": 1190
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 976
    },
    {
      "term": "FATIGUE",
      "count": 844
    },
    {
      "term": "DEATH",
      "count": 783
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 771
    },
    {
      "term": "NAUSEA",
      "count": 766
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 738
    },
    {
      "term": "DYSPNOEA",
      "count": 675
    },
    {
      "term": "PYREXIA",
      "count": 635
    },
    {
      "term": "VOMITING",
      "count": 617
    },
    {
      "term": "PNEUMONIA",
      "count": 604
    },
    {
      "term": "DRUG INTERACTION",
      "count": 553
    },
    {
      "term": "ANAEMIA",
      "count": 550
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 506
    },
    {
      "term": "STOMATITIS",
      "count": 473
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 471
    },
    {
      "term": "DECREASED APPETITE",
      "count": 458
    },
    {
      "term": "ASTHENIA",
      "count": 454
    },
    {
      "term": "METASTASES TO BONE",
      "count": 445
    },
    {
      "term": "PNEUMONITIS",
      "count": 437
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 432
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 418
    },
    {
      "term": "NEUTROPENIA",
      "count": 403
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 391
    },
    {
      "term": "COUGH",
      "count": 381
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 381
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 369
    },
    {
      "term": "RASH",
      "count": 358
    },
    {
      "term": "DEHYDRATION",
      "count": 342
    },
    {
      "term": "HYPERTENSION",
      "count": 337
    },
    {
      "term": "TRANSPLANT REJECTION",
      "count": 313
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 312
    },
    {
      "term": "POLYOMAVIRUS-ASSOCIATED NEPHROPATHY",
      "count": 300
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 298
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 297
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 293
    },
    {
      "term": "BK VIRUS INFECTION",
      "count": 290
    },
    {
      "term": "SEPSIS",
      "count": 283
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 281
    },
    {
      "term": "PAIN",
      "count": 277
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 275
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 270
    },
    {
      "term": "COVID-19",
      "count": 269
    },
    {
      "term": "RENAL FAILURE",
      "count": 269
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 263
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 258
    },
    {
      "term": "HEADACHE",
      "count": 255
    },
    {
      "term": "POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER",
      "count": 250
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 244
    },
    {
      "term": "LEUKOPENIA",
      "count": 243
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 226
    },
    {
      "term": "INFECTION",
      "count": 220
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 220
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 217
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 216
    },
    {
      "term": "BREAST CANCER",
      "count": 206
    },
    {
      "term": "MALAISE",
      "count": 205
    },
    {
      "term": "BLOOD PRESSURE INCREASED",
      "count": 201
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 201
    },
    {
      "term": "ARTHRALGIA",
      "count": 199
    },
    {
      "term": "PROTEINURIA",
      "count": 194
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 193
    },
    {
      "term": "BACK PAIN",
      "count": 192
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 190
    },
    {
      "term": "PANCYTOPENIA",
      "count": 187
    },
    {
      "term": "PRURITUS",
      "count": 180
    },
    {
      "term": "POLYOMAVIRUS VIRAEMIA",
      "count": 179
    },
    {
      "term": "THERAPY INTERRUPTED",
      "count": 178
    },
    {
      "term": "ASCITES",
      "count": 174
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 174
    },
    {
      "term": "HYPOTENSION",
      "count": 173
    },
    {
      "term": "CONSTIPATION",
      "count": 171
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 167
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 165
    },
    {
      "term": "SEIZURE",
      "count": 164
    },
    {
      "term": "OSTEONECROSIS OF JAW",
      "count": 163
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 162
    },
    {
      "term": "CHEST PAIN",
      "count": 160
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 160
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 155
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 153
    },
    {
      "term": "DIZZINESS",
      "count": 150
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 147
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 146
    },
    {
      "term": "EPSTEIN-BARR VIRUS INFECTION",
      "count": 140
    },
    {
      "term": "HOSPITALISATION",
      "count": 137
    },
    {
      "term": "DIABETES MELLITUS",
      "count": 136
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 136
    },
    {
      "term": "DRUG LEVEL INCREASED",
      "count": 135
    },
    {
      "term": "KIDNEY TRANSPLANT REJECTION",
      "count": 135
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 134
    },
    {
      "term": "MOUTH ULCERATION",
      "count": 133
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 132
    },
    {
      "term": "VIRAEMIA",
      "count": 125
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 121
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 121
    },
    {
      "term": "EPISTAXIS",
      "count": 120
    },
    {
      "term": "FALL",
      "count": 120
    }
  ]
}