{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 8216
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 7981
    },
    {
      "term": "NEUTROPENIA",
      "count": 5248
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 4695
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 4589
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 4201
    },
    {
      "term": "PYREXIA",
      "count": 3630
    },
    {
      "term": "ANAEMIA",
      "count": 3417
    },
    {
      "term": "SEPSIS",
      "count": 3118
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 3046
    },
    {
      "term": "DEATH",
      "count": 2894
    },
    {
      "term": "PANCYTOPENIA",
      "count": 2860
    },
    {
      "term": "NAUSEA",
      "count": 2634
    },
    {
      "term": "PNEUMONIA",
      "count": 2576
    },
    {
      "term": "DIARRHOEA",
      "count": 2435
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 2345
    },
    {
      "term": "VOMITING",
      "count": 2299
    },
    {
      "term": "INFECTION",
      "count": 2051
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 1996
    },
    {
      "term": "MYELOSUPPRESSION",
      "count": 1864
    },
    {
      "term": "DYSPNOEA",
      "count": 1684
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 1662
    },
    {
      "term": "FATIGUE",
      "count": 1565
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 1520
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 1482
    },
    {
      "term": "BONE MARROW FAILURE",
      "count": 1452
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 1364
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 1358
    },
    {
      "term": "LEUKOPENIA",
      "count": 1308
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 1306
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 1273
    },
    {
      "term": "HYPOTENSION",
      "count": 1230
    },
    {
      "term": "ASTHENIA",
      "count": 1228
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 1224
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 1174
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 1130
    },
    {
      "term": "RENAL FAILURE",
      "count": 1043
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 978
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 966
    },
    {
      "term": "CYTOPENIA",
      "count": 953
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 944
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 938
    },
    {
      "term": "HAEMATOTOXICITY",
      "count": 899
    },
    {
      "term": "DECREASED APPETITE",
      "count": 890
    },
    {
      "term": "STOMATITIS",
      "count": 863
    },
    {
      "term": "DISEASE RECURRENCE",
      "count": 862
    },
    {
      "term": "THERAPY PARTIAL RESPONDER",
      "count": 829
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 808
    },
    {
      "term": "COUGH",
      "count": 797
    },
    {
      "term": "HEADACHE",
      "count": 793
    },
    {
      "term": "TUMOUR LYSIS SYNDROME",
      "count": 781
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 776
    },
    {
      "term": "NEUTROPENIC SEPSIS",
      "count": 745
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 742
    },
    {
      "term": "ASPERGILLUS INFECTION",
      "count": 738
    },
    {
      "term": "RASH",
      "count": 733
    },
    {
      "term": "CONSTIPATION",
      "count": 732
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 726
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 699
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 694
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 683
    },
    {
      "term": "DEHYDRATION",
      "count": 681
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 680
    },
    {
      "term": "VENOOCCLUSIVE LIVER DISEASE",
      "count": 673
    },
    {
      "term": "COLITIS",
      "count": 672
    },
    {
      "term": "BACTERIAL INFECTION",
      "count": 666
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 663
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 661
    },
    {
      "term": "TACHYCARDIA",
      "count": 658
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 642
    },
    {
      "term": "HYPERTENSION",
      "count": 636
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 634
    },
    {
      "term": "CLOSTRIDIUM DIFFICILE COLITIS",
      "count": 632
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 628
    },
    {
      "term": "PNEUMONITIS",
      "count": 623
    },
    {
      "term": "PAIN",
      "count": 618
    },
    {
      "term": "CYTOKINE RELEASE SYNDROME",
      "count": 617
    },
    {
      "term": "SECOND PRIMARY MALIGNANCY",
      "count": 615
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 613
    },
    {
      "term": "PLASMA CELL MYELOMA",
      "count": 599
    },
    {
      "term": "FUNGAL INFECTION",
      "count": 583
    },
    {
      "term": "DIZZINESS",
      "count": 574
    },
    {
      "term": "DIFFUSE LARGE B-CELL LYMPHOMA",
      "count": 570
    },
    {
      "term": "COVID-19",
      "count": 569
    },
    {
      "term": "HAEMORRHAGE",
      "count": 567
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 566
    },
    {
      "term": "CYTOMEGALOVIRUS INFECTION",
      "count": 561
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 559
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 541
    },
    {
      "term": "BACTERAEMIA",
      "count": 540
    },
    {
      "term": "DRUG INTERACTION",
      "count": 538
    },
    {
      "term": "NEUROTOXICITY",
      "count": 536
    },
    {
      "term": "BRONCHOPULMONARY ASPERGILLOSIS",
      "count": 535
    },
    {
      "term": "HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS",
      "count": 527
    },
    {
      "term": "LYMPHADENOPATHY",
      "count": 523
    },
    {
      "term": "DRUG RESISTANCE",
      "count": 502
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 498
    },
    {
      "term": "LYMPHOPENIA",
      "count": 496
    },
    {
      "term": "BLOOD LACTATE DEHYDROGENASE INCREASED",
      "count": 493
    },
    {
      "term": "HYPOXIA",
      "count": 488
    }
  ]
}