{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 163
    },
    {
      "term": "NAUSEA",
      "count": 138
    },
    {
      "term": "DIARRHOEA",
      "count": 134
    },
    {
      "term": "FATIGUE",
      "count": 121
    },
    {
      "term": "PYREXIA",
      "count": 112
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 90
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 76
    },
    {
      "term": "ANAEMIA",
      "count": 70
    },
    {
      "term": "DEATH",
      "count": 70
    },
    {
      "term": "RASH",
      "count": 70
    },
    {
      "term": "VOMITING",
      "count": 68
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 66
    },
    {
      "term": "COLITIS",
      "count": 59
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 49
    },
    {
      "term": "DECREASED APPETITE",
      "count": 48
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 45
    },
    {
      "term": "ASTHENIA",
      "count": 45
    },
    {
      "term": "ARTHRALGIA",
      "count": 44
    },
    {
      "term": "BLOOD CREATINE PHOSPHOKINASE INCREASED",
      "count": 43
    },
    {
      "term": "DYSPNOEA",
      "count": 42
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 42
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 41
    },
    {
      "term": "CONSTIPATION",
      "count": 41
    },
    {
      "term": "SEROUS RETINAL DETACHMENT",
      "count": 41
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 38
    },
    {
      "term": "SECOND PRIMARY MALIGNANCY",
      "count": 38
    },
    {
      "term": "SEPSIS",
      "count": 37
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 35
    },
    {
      "term": "MYALGIA",
      "count": 33
    },
    {
      "term": "RASH MACULO-PAPULAR",
      "count": 33
    },
    {
      "term": "BACK PAIN",
      "count": 32
    },
    {
      "term": "HEADACHE",
      "count": 29
    },
    {
      "term": "HYPOTENSION",
      "count": 29
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 29
    },
    {
      "term": "VISION BLURRED",
      "count": 29
    },
    {
      "term": "PNEUMONITIS",
      "count": 28
    },
    {
      "term": "RENAL FAILURE",
      "count": 28
    },
    {
      "term": "SEIZURE",
      "count": 27
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 25
    },
    {
      "term": "HEPATITIS",
      "count": 25
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 25
    },
    {
      "term": "GAMMA-GLUTAMYLTRANSFERASE INCREASED",
      "count": 24
    },
    {
      "term": "HYPERTENSION",
      "count": 24
    },
    {
      "term": "PRURITUS",
      "count": 24
    },
    {
      "term": "VISUAL IMPAIRMENT",
      "count": 23
    },
    {
      "term": "PAIN",
      "count": 22
    },
    {
      "term": "SKIN TOXICITY",
      "count": 22
    },
    {
      "term": "CHILLS",
      "count": 21
    },
    {
      "term": "MALIGNANT MELANOMA",
      "count": 21
    },
    {
      "term": "UVEITIS",
      "count": 21
    },
    {
      "term": "VERTIGO",
      "count": 21
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 21
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 20
    },
    {
      "term": "MALAISE",
      "count": 20
    },
    {
      "term": "RETINOPATHY",
      "count": 20
    },
    {
      "term": "TRANSAMINASES INCREASED",
      "count": 20
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 19
    },
    {
      "term": "PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME",
      "count": 19
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 18
    },
    {
      "term": "HEPATIC CYTOLYSIS",
      "count": 18
    },
    {
      "term": "LIPASE INCREASED",
      "count": 18
    },
    {
      "term": "MELANOCYTIC NAEVUS",
      "count": 18
    },
    {
      "term": "NEUTROPENIA",
      "count": 18
    },
    {
      "term": "PNEUMONIA",
      "count": 18
    },
    {
      "term": "RETINAL DETACHMENT",
      "count": 18
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 17
    },
    {
      "term": "COLORECTAL CANCER METASTATIC",
      "count": 17
    },
    {
      "term": "DEHYDRATION",
      "count": 17
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 17
    },
    {
      "term": "ALOPECIA",
      "count": 16
    },
    {
      "term": "DIZZINESS",
      "count": 16
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 16
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 16
    },
    {
      "term": "OCULAR TOXICITY",
      "count": 16
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 16
    },
    {
      "term": "COUGH",
      "count": 15
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 15
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 15
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 15
    },
    {
      "term": "PANCREATITIS",
      "count": 15
    },
    {
      "term": "BASAL CELL CARCINOMA",
      "count": 14
    },
    {
      "term": "CHOLESTASIS",
      "count": 14
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 14
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 14
    },
    {
      "term": "HYPONATRAEMIA",
      "count": 14
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 14
    },
    {
      "term": "POLYNEUROPATHY",
      "count": 14
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 14
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 14
    },
    {
      "term": "TUMOUR LYSIS SYNDROME",
      "count": 14
    },
    {
      "term": "COLITIS ULCERATIVE",
      "count": 13
    },
    {
      "term": "EPILEPSY",
      "count": 13
    },
    {
      "term": "PHOTOSENSITIVITY REACTION",
      "count": 13
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 13
    },
    {
      "term": "C-REACTIVE PROTEIN INCREASED",
      "count": 12
    },
    {
      "term": "DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS",
      "count": 12
    },
    {
      "term": "EJECTION FRACTION DECREASED",
      "count": 12
    },
    {
      "term": "HYPERKALAEMIA",
      "count": 12
    },
    {
      "term": "HYPOTHYROIDISM",
      "count": 12
    },
    {
      "term": "LARGE INTESTINAL ULCER",
      "count": 12
    }
  ]
}