{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 150
    },
    {
      "term": "HAEMARTHROSIS",
      "count": 120
    },
    {
      "term": "HAEMORRHAGE",
      "count": 106
    },
    {
      "term": "NO ADVERSE EVENT",
      "count": 82
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 64
    },
    {
      "term": "HAEMATOMA",
      "count": 38
    },
    {
      "term": "MUSCLE HAEMORRHAGE",
      "count": 30
    },
    {
      "term": "FALL",
      "count": 29
    },
    {
      "term": "ARTHRALGIA",
      "count": 28
    },
    {
      "term": "HEADACHE",
      "count": 24
    },
    {
      "term": "ANTI FACTOR VIII ANTIBODY POSITIVE",
      "count": 22
    },
    {
      "term": "HEAD INJURY",
      "count": 22
    },
    {
      "term": "PYREXIA",
      "count": 21
    },
    {
      "term": "DRUG SPECIFIC ANTIBODY PRESENT",
      "count": 20
    },
    {
      "term": "HAEMATURIA",
      "count": 20
    },
    {
      "term": "INTENTIONAL PRODUCT USE ISSUE",
      "count": 17
    },
    {
      "term": "INJECTION SITE REACTION",
      "count": 16
    },
    {
      "term": "FACTOR VIII INHIBITION",
      "count": 15
    },
    {
      "term": "INJURY",
      "count": 15
    },
    {
      "term": "TRAUMATIC HAEMORRHAGE",
      "count": 15
    },
    {
      "term": "CONTUSION",
      "count": 14
    },
    {
      "term": "COVID-19",
      "count": 13
    },
    {
      "term": "JOINT SWELLING",
      "count": 13
    },
    {
      "term": "NEUTROPENIA",
      "count": 13
    },
    {
      "term": "POST PROCEDURAL HAEMORRHAGE",
      "count": 13
    },
    {
      "term": "SEPSIS",
      "count": 13
    },
    {
      "term": "SHOCK HAEMORRHAGIC",
      "count": 13
    },
    {
      "term": "DEATH",
      "count": 12
    },
    {
      "term": "HAEMATOMA MUSCLE",
      "count": 12
    },
    {
      "term": "TRAUMATIC HAEMATOMA",
      "count": 12
    },
    {
      "term": "GASTROINTESTINAL HAEMORRHAGE",
      "count": 11
    },
    {
      "term": "HAEMOPHILIC ARTHROPATHY",
      "count": 11
    },
    {
      "term": "PAIN",
      "count": 11
    },
    {
      "term": "EPISTAXIS",
      "count": 10
    },
    {
      "term": "HAEMORRHAGE INTRACRANIAL",
      "count": 10
    },
    {
      "term": "JOINT INJURY",
      "count": 10
    },
    {
      "term": "MYOCARDIAL INFARCTION",
      "count": 10
    },
    {
      "term": "ANTI FACTOR VIII ANTIBODY INCREASED",
      "count": 9
    },
    {
      "term": "CEREBROVASCULAR ACCIDENT",
      "count": 9
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 9
    },
    {
      "term": "PROCEDURAL HAEMORRHAGE",
      "count": 9
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 9
    },
    {
      "term": "THROMBOSIS",
      "count": 9
    },
    {
      "term": "VOMITING",
      "count": 9
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 9
    },
    {
      "term": "ANAEMIA",
      "count": 8
    },
    {
      "term": "ARTHROPATHY",
      "count": 8
    },
    {
      "term": "DEEP VEIN THROMBOSIS",
      "count": 8
    },
    {
      "term": "KNEE ARTHROPLASTY",
      "count": 8
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 8
    },
    {
      "term": "SPONTANEOUS HAEMORRHAGE",
      "count": 8
    },
    {
      "term": "SUBDURAL HAEMORRHAGE",
      "count": 8
    },
    {
      "term": "SYNOVITIS",
      "count": 8
    },
    {
      "term": "THERAPEUTIC RESPONSE DECREASED",
      "count": 8
    },
    {
      "term": "THROMBOTIC MICROANGIOPATHY",
      "count": 8
    },
    {
      "term": "TREATMENT NONCOMPLIANCE",
      "count": 8
    },
    {
      "term": "SEIZURE",
      "count": 7
    },
    {
      "term": "SUBARACHNOID HAEMORRHAGE",
      "count": 7
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 7
    },
    {
      "term": "ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED",
      "count": 6
    },
    {
      "term": "ACUTE MYOCARDIAL INFARCTION",
      "count": 6
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 6
    },
    {
      "term": "BRONCHITIS",
      "count": 6
    },
    {
      "term": "CEREBRAL HAEMORRHAGE",
      "count": 6
    },
    {
      "term": "EXTRADURAL HAEMATOMA",
      "count": 6
    },
    {
      "term": "GAIT DISTURBANCE",
      "count": 6
    },
    {
      "term": "HAEMOPERITONEUM",
      "count": 6
    },
    {
      "term": "INFECTION",
      "count": 6
    },
    {
      "term": "INTRA-ABDOMINAL HAEMORRHAGE",
      "count": 6
    },
    {
      "term": "LIMB INJURY",
      "count": 6
    },
    {
      "term": "OSTEOARTHRITIS",
      "count": 6
    },
    {
      "term": "PERITONITIS",
      "count": 6
    },
    {
      "term": "PRODUCT DISPENSING ERROR",
      "count": 6
    },
    {
      "term": "SKULL FRACTURE",
      "count": 6
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 6
    },
    {
      "term": "TREATMENT FAILURE",
      "count": 6
    },
    {
      "term": "ARTHRITIS BACTERIAL",
      "count": 5
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 5
    },
    {
      "term": "DEVICE RELATED THROMBOSIS",
      "count": 5
    },
    {
      "term": "DRUG EFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 5
    },
    {
      "term": "DYSPNOEA",
      "count": 5
    },
    {
      "term": "EPILEPSY",
      "count": 5
    },
    {
      "term": "ERYTHEMA",
      "count": 5
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 5
    },
    {
      "term": "HYPERSENSITIVITY",
      "count": 5
    },
    {
      "term": "INJECTION SITE PAIN",
      "count": 5
    },
    {
      "term": "MASS",
      "count": 5
    },
    {
      "term": "MYALGIA",
      "count": 5
    },
    {
      "term": "NAUSEA",
      "count": 5
    },
    {
      "term": "NEOPLASM MALIGNANT",
      "count": 5
    },
    {
      "term": "NEUTROPENIC SEPSIS",
      "count": 5
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 5
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 5
    },
    {
      "term": "PNEUMONIA ASPIRATION",
      "count": 5
    },
    {
      "term": "RECTAL HAEMORRHAGE",
      "count": 5
    },
    {
      "term": "RENAL INFARCT",
      "count": 5
    },
    {
      "term": "RETROPERITONEAL HAEMORRHAGE",
      "count": 5
    },
    {
      "term": "SUBDURAL HAEMATOMA",
      "count": 5
    },
    {
      "term": "SYNCOPE",
      "count": 5
    },
    {
      "term": "ABDOMINAL INJURY",
      "count": 4
    }
  ]
}