{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OFF LABEL USE",
      "count": 588
    },
    {
      "term": "BRADYCARDIA",
      "count": 420
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 420
    },
    {
      "term": "HYPOTENSION",
      "count": 302
    },
    {
      "term": "CARDIAC ARREST",
      "count": 264
    },
    {
      "term": "DRUG INTERACTION",
      "count": 254
    },
    {
      "term": "AGITATION",
      "count": 209
    },
    {
      "term": "RESPIRATORY FAILURE",
      "count": 176
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 165
    },
    {
      "term": "DELIRIUM",
      "count": 163
    },
    {
      "term": "PYREXIA",
      "count": 146
    },
    {
      "term": "TACHYCARDIA",
      "count": 143
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 134
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 122
    },
    {
      "term": "DRUG INEFFECTIVE FOR UNAPPROVED INDICATION",
      "count": 118
    },
    {
      "term": "DIABETES INSIPIDUS",
      "count": 113
    },
    {
      "term": "WITHDRAWAL SYNDROME",
      "count": 112
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 109
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 109
    },
    {
      "term": "DRUG WITHDRAWAL SYNDROME",
      "count": 106
    },
    {
      "term": "HYPERTENSION",
      "count": 104
    },
    {
      "term": "PNEUMONIA",
      "count": 99
    },
    {
      "term": "HYPOXIA",
      "count": 96
    },
    {
      "term": "OXYGEN SATURATION DECREASED",
      "count": 94
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 94
    },
    {
      "term": "HYPERTHERMIA",
      "count": 88
    },
    {
      "term": "OVERDOSE",
      "count": 88
    },
    {
      "term": "RESPIRATORY DEPRESSION",
      "count": 84
    },
    {
      "term": "SEPSIS",
      "count": 82
    },
    {
      "term": "SEROTONIN SYNDROME",
      "count": 80
    },
    {
      "term": "SOMNOLENCE",
      "count": 78
    },
    {
      "term": "PRODUCT ADMINISTERED TO PATIENT OF INAPPROPRIATE AGE",
      "count": 76
    },
    {
      "term": "SEIZURE",
      "count": 75
    },
    {
      "term": "TACHYPNOEA",
      "count": 74
    },
    {
      "term": "ARTERIOSPASM CORONARY",
      "count": 73
    },
    {
      "term": "DYSPNOEA",
      "count": 73
    },
    {
      "term": "GENERALISED TONIC-CLONIC SEIZURE",
      "count": 72
    },
    {
      "term": "VOMITING",
      "count": 72
    },
    {
      "term": "TORSADE DE POINTES",
      "count": 71
    },
    {
      "term": "NAUSEA",
      "count": 66
    },
    {
      "term": "MYOCLONUS",
      "count": 65
    },
    {
      "term": "SEDATION COMPLICATION",
      "count": 65
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 62
    },
    {
      "term": "DEATH",
      "count": 61
    },
    {
      "term": "ANAESTHETIC COMPLICATION NEUROLOGICAL",
      "count": 60
    },
    {
      "term": "MATERNAL EXPOSURE DURING PREGNANCY",
      "count": 59
    },
    {
      "term": "MENTAL STATUS CHANGES",
      "count": 58
    },
    {
      "term": "FOETAL EXPOSURE DURING PREGNANCY",
      "count": 56
    },
    {
      "term": "SINUS BRADYCARDIA",
      "count": 56
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 55
    },
    {
      "term": "POLYURIA",
      "count": 55
    },
    {
      "term": "VENTRICULAR TACHYCARDIA",
      "count": 55
    },
    {
      "term": "BLOOD PRESSURE DECREASED",
      "count": 54
    },
    {
      "term": "APNOEA",
      "count": 52
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 52
    },
    {
      "term": "NEUROLEPTIC MALIGNANT SYNDROME",
      "count": 52
    },
    {
      "term": "SINUS ARREST",
      "count": 52
    },
    {
      "term": "CONFUSIONAL STATE",
      "count": 51
    },
    {
      "term": "CARDIO-RESPIRATORY ARREST",
      "count": 50
    },
    {
      "term": "PAIN",
      "count": 50
    },
    {
      "term": "RENAL FAILURE",
      "count": 50
    },
    {
      "term": "HYPERTHERMIA MALIGNANT",
      "count": 49
    },
    {
      "term": "LOSS OF CONSCIOUSNESS",
      "count": 49
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 49
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 49
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 47
    },
    {
      "term": "UPPER AIRWAY OBSTRUCTION",
      "count": 47
    },
    {
      "term": "UNRESPONSIVE TO STIMULI",
      "count": 46
    },
    {
      "term": "HAEMODYNAMIC INSTABILITY",
      "count": 45
    },
    {
      "term": "RHABDOMYOLYSIS",
      "count": 45
    },
    {
      "term": "SEDATION",
      "count": 45
    },
    {
      "term": "NO ADVERSE EVENT",
      "count": 44
    },
    {
      "term": "RESPIRATORY DISTRESS",
      "count": 43
    },
    {
      "term": "VENTRICULAR FIBRILLATION",
      "count": 43
    },
    {
      "term": "ENCEPHALOPATHY",
      "count": 42
    },
    {
      "term": "EXPOSURE DURING PREGNANCY",
      "count": 42
    },
    {
      "term": "ACCIDENTAL OVERDOSE",
      "count": 41
    },
    {
      "term": "AGGRESSION",
      "count": 41
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 41
    },
    {
      "term": "PULMONARY OEDEMA",
      "count": 41
    },
    {
      "term": "ATRIOVENTRICULAR BLOCK COMPLETE",
      "count": 40
    },
    {
      "term": "DRUG ADMINISTERED TO PATIENT OF INAPPROPRIATE AGE",
      "count": 40
    },
    {
      "term": "INTESTINAL PSEUDO-OBSTRUCTION",
      "count": 40
    },
    {
      "term": "ANAPHYLACTIC REACTION",
      "count": 39
    },
    {
      "term": "ANAPHYLACTIC SHOCK",
      "count": 39
    },
    {
      "term": "HYPOTHERMIA",
      "count": 39
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 39
    },
    {
      "term": "PARADOXICAL DRUG REACTION",
      "count": 39
    },
    {
      "term": "SYNCOPE",
      "count": 39
    },
    {
      "term": "ANAEMIA",
      "count": 38
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 38
    },
    {
      "term": "DIARRHOEA",
      "count": 38
    },
    {
      "term": "POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME",
      "count": 38
    },
    {
      "term": "APLASTIC ANAEMIA",
      "count": 37
    },
    {
      "term": "THERAPY NON-RESPONDER",
      "count": 37
    },
    {
      "term": "ACUTE RESPIRATORY FAILURE",
      "count": 36
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 36
    },
    {
      "term": "CONSTIPATION",
      "count": 36
    },
    {
      "term": "HYPERGLYCAEMIA",
      "count": 36
    },
    {
      "term": "PNEUMONIA ASPIRATION",
      "count": 36
    }
  ]
}