{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "OSTEONECROSIS OF JAW",
      "count": 1471
    },
    {
      "term": "DIARRHOEA",
      "count": 1115
    },
    {
      "term": "FATIGUE",
      "count": 1070
    },
    {
      "term": "NAUSEA",
      "count": 1041
    },
    {
      "term": "MALIGNANT NEOPLASM PROGRESSION",
      "count": 1006
    },
    {
      "term": "NEUTROPENIA",
      "count": 867
    },
    {
      "term": "METASTASES TO BONE",
      "count": 802
    },
    {
      "term": "OFF LABEL USE",
      "count": 782
    },
    {
      "term": "ANAEMIA",
      "count": 727
    },
    {
      "term": "VOMITING",
      "count": 607
    },
    {
      "term": "DECREASED APPETITE",
      "count": 585
    },
    {
      "term": "DYSPNOEA",
      "count": 567
    },
    {
      "term": "HYPOCALCAEMIA",
      "count": 554
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 515
    },
    {
      "term": "ARTHRALGIA",
      "count": 501
    },
    {
      "term": "PYREXIA",
      "count": 496
    },
    {
      "term": "ASTHENIA",
      "count": 493
    },
    {
      "term": "DISEASE PROGRESSION",
      "count": 476
    },
    {
      "term": "PAIN",
      "count": 455
    },
    {
      "term": "DEATH",
      "count": 446
    },
    {
      "term": "FALL",
      "count": 430
    },
    {
      "term": "METASTASES TO LIVER",
      "count": 428
    },
    {
      "term": "BACK PAIN",
      "count": 426
    },
    {
      "term": "PNEUMONIA",
      "count": 399
    },
    {
      "term": "RASH",
      "count": 399
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 382
    },
    {
      "term": "HEADACHE",
      "count": 373
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 364
    },
    {
      "term": "CONSTIPATION",
      "count": 324
    },
    {
      "term": "NEOPLASM PROGRESSION",
      "count": 324
    },
    {
      "term": "MALAISE",
      "count": 323
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 323
    },
    {
      "term": "NEUROPATHY PERIPHERAL",
      "count": 321
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 319
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 311
    },
    {
      "term": "ALOPECIA",
      "count": 308
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 291
    },
    {
      "term": "PLEURAL EFFUSION",
      "count": 289
    },
    {
      "term": "LEUKOPENIA",
      "count": 284
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 284
    },
    {
      "term": "DIZZINESS",
      "count": 283
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 281
    },
    {
      "term": "HYPERTENSION",
      "count": 276
    },
    {
      "term": "COUGH",
      "count": 271
    },
    {
      "term": "METASTASES TO LUNG",
      "count": 266
    },
    {
      "term": "SEPSIS",
      "count": 254
    },
    {
      "term": "MUCOSAL INFLAMMATION",
      "count": 253
    },
    {
      "term": "PRURITUS",
      "count": 252
    },
    {
      "term": "BREAST CANCER METASTATIC",
      "count": 240
    },
    {
      "term": "CELLULITIS",
      "count": 232
    },
    {
      "term": "METASTASES TO LYMPH NODES",
      "count": 232
    },
    {
      "term": "COVID-19",
      "count": 230
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 228
    },
    {
      "term": "FEMUR FRACTURE",
      "count": 227
    },
    {
      "term": "PULMONARY EMBOLISM",
      "count": 225
    },
    {
      "term": "DRUG INTERACTION",
      "count": 216
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 213
    },
    {
      "term": "BREAST CANCER",
      "count": 206
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 205
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 205
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 204
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 202
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 201
    },
    {
      "term": "INTERSTITIAL LUNG DISEASE",
      "count": 199
    },
    {
      "term": "BONE PAIN",
      "count": 189
    },
    {
      "term": "DEHYDRATION",
      "count": 186
    },
    {
      "term": "OSTEOMYELITIS",
      "count": 176
    },
    {
      "term": "HYPOTENSION",
      "count": 175
    },
    {
      "term": "ATYPICAL FEMUR FRACTURE",
      "count": 172
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 172
    },
    {
      "term": "INSOMNIA",
      "count": 172
    },
    {
      "term": "METASTASES TO CENTRAL NERVOUS SYSTEM",
      "count": 172
    },
    {
      "term": "STOMATITIS",
      "count": 169
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 168
    },
    {
      "term": "SPINAL FRACTURE",
      "count": 163
    },
    {
      "term": "EPISTAXIS",
      "count": 155
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 154
    },
    {
      "term": "PNEUMONITIS",
      "count": 154
    },
    {
      "term": "CHEST PAIN",
      "count": 151
    },
    {
      "term": "ATRIAL FIBRILLATION",
      "count": 149
    },
    {
      "term": "HYPERCALCAEMIA",
      "count": 146
    },
    {
      "term": "PARAESTHESIA",
      "count": 146
    },
    {
      "term": "PROSTATIC SPECIFIC ANTIGEN INCREASED",
      "count": 146
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 142
    },
    {
      "term": "HOT FLUSH",
      "count": 142
    },
    {
      "term": "OSTEOPOROSIS",
      "count": 142
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 141
    },
    {
      "term": "DYSPEPSIA",
      "count": 140
    },
    {
      "term": "INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION",
      "count": 136
    },
    {
      "term": "FRACTURE",
      "count": 135
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 135
    },
    {
      "term": "PANCYTOPENIA",
      "count": 135
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 135
    },
    {
      "term": "ERYTHEMA",
      "count": 132
    },
    {
      "term": "MYALGIA",
      "count": 132
    },
    {
      "term": "ANXIETY",
      "count": 131
    },
    {
      "term": "SPINAL COMPRESSION FRACTURE",
      "count": 131
    },
    {
      "term": "ELECTROCARDIOGRAM QT PROLONGED",
      "count": 130
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 128
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 127
    }
  ]
}