{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-04-28"
  },
  "results": [
    {
      "term": "SICKLE CELL ANAEMIA WITH CRISIS",
      "count": 407
    },
    {
      "term": "DEATH",
      "count": 192
    },
    {
      "term": "DIARRHOEA",
      "count": 191
    },
    {
      "term": "PYREXIA",
      "count": 180
    },
    {
      "term": "OFF LABEL USE",
      "count": 149
    },
    {
      "term": "DRUG INEFFECTIVE",
      "count": 137
    },
    {
      "term": "THERAPY INTERRUPTED",
      "count": 137
    },
    {
      "term": "VOMITING",
      "count": 127
    },
    {
      "term": "HOSPITALISATION",
      "count": 124
    },
    {
      "term": "HAEMOGLOBIN DECREASED",
      "count": 120
    },
    {
      "term": "NAUSEA",
      "count": 117
    },
    {
      "term": "ANAEMIA",
      "count": 116
    },
    {
      "term": "ABDOMINAL PAIN",
      "count": 111
    },
    {
      "term": "PNEUMONIA",
      "count": 102
    },
    {
      "term": "FATIGUE",
      "count": 101
    },
    {
      "term": "PRODUCT DOSE OMISSION ISSUE",
      "count": 90
    },
    {
      "term": "PLATELET COUNT DECREASED",
      "count": 82
    },
    {
      "term": "THROMBOCYTOPENIA",
      "count": 82
    },
    {
      "term": "SEPSIS",
      "count": 75
    },
    {
      "term": "DYSPNOEA",
      "count": 73
    },
    {
      "term": "FEBRILE NEUTROPENIA",
      "count": 70
    },
    {
      "term": "ASTHENIA",
      "count": 68
    },
    {
      "term": "SERUM FERRITIN INCREASED",
      "count": 67
    },
    {
      "term": "NEPHROLITHIASIS",
      "count": 66
    },
    {
      "term": "PAIN",
      "count": 63
    },
    {
      "term": "WEIGHT DECREASED",
      "count": 58
    },
    {
      "term": "ACUTE KIDNEY INJURY",
      "count": 55
    },
    {
      "term": "HEADACHE",
      "count": 55
    },
    {
      "term": "HYPERAMMONAEMIA",
      "count": 54
    },
    {
      "term": "MALAISE",
      "count": 53
    },
    {
      "term": "DECREASED APPETITE",
      "count": 52
    },
    {
      "term": "METABOLIC ACIDOSIS",
      "count": 51
    },
    {
      "term": "RASH",
      "count": 47
    },
    {
      "term": "NEUTROPENIA",
      "count": 46
    },
    {
      "term": "RENAL IMPAIRMENT",
      "count": 45
    },
    {
      "term": "ABDOMINAL PAIN UPPER",
      "count": 44
    },
    {
      "term": "WHITE BLOOD CELL COUNT DECREASED",
      "count": 43
    },
    {
      "term": "BLOOD CREATININE INCREASED",
      "count": 42
    },
    {
      "term": "CONDITION AGGRAVATED",
      "count": 42
    },
    {
      "term": "DIZZINESS",
      "count": 41
    },
    {
      "term": "IRON OVERLOAD",
      "count": 41
    },
    {
      "term": "OEDEMA PERIPHERAL",
      "count": 40
    },
    {
      "term": "RENAL FAILURE",
      "count": 40
    },
    {
      "term": "FALL",
      "count": 38
    },
    {
      "term": "HYPOTENSION",
      "count": 37
    },
    {
      "term": "PANCYTOPENIA",
      "count": 37
    },
    {
      "term": "DRUG INTERACTION",
      "count": 36
    },
    {
      "term": "TREATMENT NONCOMPLIANCE",
      "count": 35
    },
    {
      "term": "WEIGHT INCREASED",
      "count": 34
    },
    {
      "term": "ARTHRALGIA",
      "count": 33
    },
    {
      "term": "INFECTION",
      "count": 33
    },
    {
      "term": "PAIN IN EXTREMITY",
      "count": 33
    },
    {
      "term": "PRODUCT USE IN UNAPPROVED INDICATION",
      "count": 33
    },
    {
      "term": "CONSTIPATION",
      "count": 32
    },
    {
      "term": "TOXICITY TO VARIOUS AGENTS",
      "count": 32
    },
    {
      "term": "COVID-19",
      "count": 31
    },
    {
      "term": "DEHYDRATION",
      "count": 31
    },
    {
      "term": "ABDOMINAL DISCOMFORT",
      "count": 30
    },
    {
      "term": "COUGH",
      "count": 30
    },
    {
      "term": "GENERAL PHYSICAL HEALTH DETERIORATION",
      "count": 29
    },
    {
      "term": "MYELODYSPLASTIC SYNDROME",
      "count": 29
    },
    {
      "term": "PROTEINURIA",
      "count": 29
    },
    {
      "term": "PRURITUS",
      "count": 29
    },
    {
      "term": "TRANSFUSION",
      "count": 29
    },
    {
      "term": "URINARY TRACT INFECTION",
      "count": 29
    },
    {
      "term": "HYPOKALAEMIA",
      "count": 28
    },
    {
      "term": "ALANINE AMINOTRANSFERASE INCREASED",
      "count": 27
    },
    {
      "term": "DRUG INTOLERANCE",
      "count": 27
    },
    {
      "term": "SEIZURE",
      "count": 27
    },
    {
      "term": "SICKLE CELL DISEASE",
      "count": 27
    },
    {
      "term": "HEPATIC FAILURE",
      "count": 26
    },
    {
      "term": "BLOOD BILIRUBIN INCREASED",
      "count": 25
    },
    {
      "term": "SEPTIC SHOCK",
      "count": 25
    },
    {
      "term": "THROMBOSIS",
      "count": 25
    },
    {
      "term": "CARDIAC FAILURE",
      "count": 24
    },
    {
      "term": "HAEMOLYSIS",
      "count": 24
    },
    {
      "term": "HEPATOTOXICITY",
      "count": 24
    },
    {
      "term": "NEPHROPATHY TOXIC",
      "count": 24
    },
    {
      "term": "NEUTROPHIL COUNT DECREASED",
      "count": 24
    },
    {
      "term": "PRODUCT USE ISSUE",
      "count": 24
    },
    {
      "term": "ACUTE MYELOID LEUKAEMIA",
      "count": 23
    },
    {
      "term": "GASTROINTESTINAL DISORDER",
      "count": 23
    },
    {
      "term": "HEPATIC ENZYME INCREASED",
      "count": 23
    },
    {
      "term": "TACHYCARDIA",
      "count": 23
    },
    {
      "term": "ACUTE HEPATIC FAILURE",
      "count": 22
    },
    {
      "term": "ASPARTATE AMINOTRANSFERASE INCREASED",
      "count": 22
    },
    {
      "term": "BACK PAIN",
      "count": 22
    },
    {
      "term": "DRUG-INDUCED LIVER INJURY",
      "count": 22
    },
    {
      "term": "FULL BLOOD COUNT DECREASED",
      "count": 22
    },
    {
      "term": "JAUNDICE",
      "count": 22
    },
    {
      "term": "MULTIPLE ORGAN DYSFUNCTION SYNDROME",
      "count": 22
    },
    {
      "term": "CARDIAC FAILURE CONGESTIVE",
      "count": 21
    },
    {
      "term": "CHILLS",
      "count": 21
    },
    {
      "term": "SOMNOLENCE",
      "count": 21
    },
    {
      "term": "BLOOD UREA INCREASED",
      "count": 20
    },
    {
      "term": "CHEST PAIN",
      "count": 20
    },
    {
      "term": "COLITIS",
      "count": 20
    },
    {
      "term": "HEPATIC ENCEPHALOPATHY",
      "count": 20
    },
    {
      "term": "HEPATIC FUNCTION ABNORMAL",
      "count": 20
    },
    {
      "term": "LEUKOPENIA",
      "count": 20
    }
  ]
}